<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17091

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSNIYWRIYTEEPNITNLPGEAPANGYTILKHLSRLKDLELRLRNLDCLVSSYPRRLGLWVFSATPDFEGLGPLCSHGVKDEQSRLVVGASTLKVSASGNITSWDIVKNLSSDPQNASGNPAGPQRQQNTAGTPTRRMDGYSSSATIYASFISAVTGALNLQLIRRNKVIPLGSRSLFTNVDRECYENLKTTNNDPSSFSALTTLQVQLTSAGKLTVTLQTISQPGILRLHQPGDHLTALQNVPSGVDVWLSPSGSVARLVTTNPGPTDAFSPYPSGEGVAIDGNDTAQRKQWKLTVLEWLKNFGLAVDSVEETTWVEVEVWEPFYSRLAGETLRPKEENTFSLPLKRILWPAVFCFRRARSATSEPVQTDSPMSEDPLDFAQKWRATDIPENSDANPKLPPNQQEPRAKDQDMPLAGSADLPEGFESLSRASQYPELQTASLVYPTPPDGAVGMGLNSAAPPSDGLVDDADFALSFAQSHGKQRVQDHLSAKDRSDVDVQMDFGPSAGLMVGSGLYDTNDDDDLFGDMNVKDFGSKGITDADFSFFDDHDFDRMGGGAQHVVEDMPDMMDSSGPEMQSAPVETITPEVSVPQKTPIEHASLPDMSPLQEDTPKSTQQEIPVHDTPVDPSSPDENNQTISPPLSPVEIKKILLPGPNGKDQTPPGHLQGQSYYNPVTFKRNVSNWDQKYGAAGKFWFTATDAGATREPTNSMGDIPTIGIPRRNRKFSAAEGISKAFDGQASPPSDEGAEPWQDSDSSSESSDESDSAVSERGASPATFSTRKRKRARSNSSSLAAQVKSLEEPDQESSVPTAGQSIFLGNFLSTFSDWSMTGYFSFPENQVLPVLARKDLQVQVAQILADQVTQSSLDHKLDGRGGISDLDDGAYSIRTFLEDTEFMDGMERLDLNGFISLQDNNQSSPPVNSANSRQALQRKETGKGSMSKLSPPHVRVRRGKEFLETLPPAVSFWETFGLEPAFGPKDIAAYCICPQNTTEAADAFLERIGLLYAGCNLGVHARGDKSNGLDQTLGSWNIESLDYLSAMQSLKVICEALGTALQNVPPSKDNIVIYMINPFTHAAAMVDLCSAFWALFQKYAADSEKQQTRVFNEVVLQIVPIDFISSTESLVVPPQVEYLSLALEVYSRCPPKNAQPSLVNCAPPMLLAEPLPRSLNFRLASEKPSPLQEGKCLHVACSRSQDQRWISVAWSDNTGSLQRTMSYNLRFRGGNSSRNVHDIRGEIWGATKDIMERISARWRLMVVHTGPVDQDEVDAWSNFVEQYNKTSTMPSELTVLNVNTAPELYLEPPFIPIPMSVFNAQTSSTPVATPNPSVLSPDQTGNAPTPPSGANAPTPTEATLEAESESLLTDICDESWGVILSHRLNSSPHLTEYRPALTSGYLLRRKGATDGDGLYALTVNLIYTQRHSSTHETLLREALGMYRDLATLARARGTCAVQRNTMPWHIATAIRAQELLSYVL
Length1491
PositionKinase
OrganismAspergillus steynii IBT 23096
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.428
Instability index51.58
Isoelectric point4.90
Molecular weight162992.12
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     206.47|      37|      37|     587|     623|       1
---------------------------------------------------------------------------
  381-  418 (25.93/ 8.30)	.............................SEPVQTDSPmseDPLDFAQkwraT....DIPENSdaNPKLPP
  427-  479 (25.30/ 7.90)	DqdmplagsadlpegfeslsraSQYPELQTASLVYPTP.......PD.....GavgmGLNSAA...PP...
  587-  623 (64.47/33.12)	D.....................SSGPEMQSAPVETITP...EVSVPQK....T....PIEHAS..LPDMSP
  627-  661 (58.49/29.27)	D.....................TPKSTQQEIPVHDTPV...DPSSPDE....N......NQTI..SPPLSP
 1335- 1358 (32.28/12.40)	.............................STPVATPNP...SVLSPDQ....T....G..NAP..TPP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     365.18|     115|     813|     254|     376|       2
---------------------------------------------------------------------------
  254-  376 (187.44/114.21)	TALQNVPSGVD...VWL.SPSGSVARLVTTNPGPTDAFSPYpsgegvAIDgNDTAQRKQWKLTVLEWLK.NFGLAVDSVEETTWVE.VEVWEPFYSRLAGETLRPKEEN.TFSLPLKRILwPAVFCFRRA
 1070- 1191 (177.74/90.73)	TALQNVPPSKDnivIYMiNPFTHAAAMVDLCSAFWALFQKY......AAD.SEKQQTRVFNEVVLQIVPiDFISSTESLVVPPQVEyLSLALEVYSRCPPKNAQPSLVNcAPPMLLAEPL.PRSLNFRLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     502.60|     140|     142|     779|     920|       3
---------------------------------------------------------------------------
  669-  782 (94.58/56.94)	..................................LPGPNGKDQTPPGhlqGQSYYNPvTFKRNVSNWdqkyGAAGK.FWFtatdagatrePTNSMgdIPTIGipRRN.....................RKFSAAEGISK.AFD..GQASPPSD.EGAEpWQDSdssSESSDESD
  783-  924 (219.76/153.66)	SAVSERGASPATFSTRKRKRARSNSSSLAAQVKsLEEPDQESSVPTA...GQSIFLG.NFLSTFSDW....SMTGY.FSF..........PENQV..LPVLA..RKDLQVQVAQILADQVT..QSSLDHKLDGRGGISD.LDD..GAYSIRTFlEDTE.FMDG...MERLDLNG
  927- 1061 (188.26/123.10)	SLQDNNQSSPPVNSANSRQALQRKETGKGSMSK.LSPP..HVRV.RR...GKE.FLE.TLPPAVSFW....ETFGLePAF..........GPKDI..AAYCI..CPQNTTEAADAFLERIGllYAGCNLGVHARGDKSNgLDQtlGSWNI....ESLD.YLSA...MQSL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.34|      16|      68|     484|     501|       6
---------------------------------------------------------------------------
  484-  501 (26.00/19.06)	VDDADFalSFAQSHGKQR
  555-  570 (31.34/17.15)	ITDADF..SFFDDHDFDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17091 with Med13 domain of Kingdom Fungi
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