<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17090

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRASASFRLEPPSPSSPAAGSLKENHSSFIPSEPTPQTPTSPPLMSVGAQNYASNFASSQASPSQATSQPANLSSPPSSAPMSTQASQQPTLGVTNSFPTPASSVSGHFTGATSGDDPDHPDKSGVSSASTQHAEHRRTDHDRQPGDAMMESGMRDTTHSGDPNLSRYGDGAMDVDTEPGVPSNPDEFSLDSLQKEFASAYHLCKSSHIATGPDPSLDLVSLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKAVKADPTSTSTLRHLTMWPEDEWQNQKVHGKEIKMADMDSALQKLHMKAMHMEPGPIPNSEQWEDVLGHEKPSKHAGSGEGSSKKAGALPNNARGPPTQPNGTPTAATASDADRSRPSRGRKRHYDENSFVGYGEGYADDDDDGAFYSNSEGMGKKKRKKEHVSKIGTPLPDRGGSYGIGMYGIGAR
Length453
PositionHead
OrganismAspergillus steynii IBT 23096
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.05
Grand average of hydropathy-0.896
Instability index44.41
Isoelectric point6.28
Molecular weight48034.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17090
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.09|      43|      43|      79|     121|       1
---------------------------------------------------------------------------
   34-   66 (46.93/16.08)	..SEPTPQTPTSPPLMSV......GAQNY..ASNF..ASSQASPS
   79-  121 (73.50/28.97)	PSSAPMSTQASQQPTLGVTNSFPTPASSV..SGHFTGATSGDDPD
  123-  166 (64.65/24.67)	PDKSGVSSASTQHAEHRRTDHDRQPGDAMmeSGMRDTTHSG.DPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.85|      21|      43|     319|     340|       2
---------------------------------------------------------------------------
  319-  340 (35.54/22.10)	EPGPIPNSEQWEDVlGHEKPSK
  365-  385 (36.32/18.47)	QPNGTPTAATASDA.DRSRPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.08|      17|      25|     183|     205|       4
---------------------------------------------------------------------------
  183-  205 (21.94/25.39)	VPSNPDEfSLDslqkeFASAYHL
  211-  227 (31.14/16.54)	IATGPDP.SLD.....LVSLYGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.62|      19|      54|     343|     361|       5
---------------------------------------------------------------------------
  343-  361 (34.39/16.86)	GSGEG..SSKKAGALPNNARG
  398-  418 (32.23/15.38)	GYGEGyaDDDDDGAFYSNSEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17090 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LGLAGRNKAVKADPTSTSTLRHLTMWPEDEWQNQKVHGKEIKMADMDSALQKLHMKAMHMEPGPIPNSEQWEDVLGHEKPSKHAGSGEGSSKKAGALPNNARGPPTQPNGTPTAATASDADRSRPSRGRKRHYDENSFVGYGEGYADDDDDGAFYSNSEGMGKKKRKKEHVSKIGTPLPDRGGSYGIGMY
2) MSDRASASFRLEPPSPSSPAAGSLKENHSSFIPSEPTPQTPTSPPLMSVGAQNYASNFASSQASPSQATSQPANLSSPPSSAPMSTQASQQPTLGVTNSFPTPASSVSGHFTGATSGDDPDHPDKSGVSSASTQHAEHRRTDHDRQPGDAMMESGMRDTTHSGDPNLSRYGDGAMDVDTEPGVPSNPDEFSLDS
259
1
448
194










Molecular Recognition Features






MoRF SequenceStartStop




1) GSYGIGMYGIGAR
2) KKKRKKEHVSKIGTPL
3) RASASFRL
441
421
4
453
436
11