<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17087

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGTFLHQCLMHRIDAAEFKNLSKLLLQKCPIGETPLLNVLLETRLATGIKWDPLLPLYVDCLCKMGQVQTSTVLHSLLKYSSIHDRPFSADSETAANPKKPSKCYTFMTDIRIIQDAMLSISTGHAPKSLAEAVGILAAIVDWMQAVVSWHNNHLDASQQAEGLLSSPDAVSLFESLGILLAALSGTTRGLDVLSSNSHEALKVKLGQALSGYLPLCMEVSLALRNRLDSLQKEFNLYGEPHSKSLEESMMDNVNVNALQFEASVMDGPIINSRAGLCIYINAMLAGRPLVDDTMMLNFLTNRYGGHNEVLIEEIITAAFDVLSNAMYRNESSRTMFLFRSFLVNKLPGFFAAMLAASVVSLPMELCISHALSRLDPRIFPSFSQMFSMQGSTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTVPVGHNKDHLVSQINMHPERTEQLIGEIESTEGNAGAIVGAITEVMFNLCNQKETMTLKNICNSLSRRPQALDVILLFRSPRQILQPLCALLDSWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLKPYDLGIGNNDSFVLKLLERGSCSQKLEDLNEKQNKNLASWIGALFIAEGISEETMSACSPQEFYLLVATLFDQSLGACEAGKLEFETLKGGFEYLLEPFLLPSLVVALAWLGNHIWESENDPSIPLKALHSLVSPSSISGEAKEIHRTVLNITARPLEEQLKDIRTRQQSRTDLKPILDALEPCLSFQRTGSCGRSELDGWTQAPGSLLGSIRSTFQALMLWSTSPDVSMTPSAYTHRQLIAGIRILGSVRVLGALIEELKLQTEAGNGPLTIDIAATMICSPLAESFAVEQSHYHPVDPSKEALPRCPILTLRDALLIQHENVAKMSEKDPLRAEIVVRLQRRVNALTAPTTQMPNLDMSNIIQNMQLGVEGPGQMDLEPSGAGPEVGEDDATNLTRIMGNAAAAVGMDGGVGQNMGGGLDTNIDDMLSAADMTVGNPEFLDLDMEGMF
Length1012
PositionTail
OrganismAspergillus steynii IBT 23096
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy-0.017
Instability index47.78
Isoelectric point4.96
Molecular weight111200.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17087
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.33|      40|      42|     294|     335|       1
---------------------------------------------------------------------------
  235-  267 (42.72/24.88)	.....DSLQK..EF..NLYGeP.HSKSL.EESMMDNVNV...NALQF
  294-  335 (64.36/48.37)	RPlvDDTMML..NFLTNRYG.G.HNEVLIEEIITAAFDV.LSNAMYR
  337-  380 (47.26/29.03)	ES..SRTMFLfrSFLVNKLP.GfFAAMLAASVVSLPMELcISHALSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.35|      25|      42|     121|     146|       2
---------------------------------------------------------------------------
  121-  146 (37.65/31.28)	QDAMLSISTGHApKSLAEAVGIL.AAI
  165-  190 (37.71/25.11)	QQAEGLLSSPDA.VSLFESLGILlAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.88|      25|     170|     558|     586|       3
---------------------------------------------------------------------------
  558-  586 (40.00/37.32)	RYDLKPydlgIGNNDSFVLKLLERGSCSQ
  733-  757 (46.88/31.39)	RTDLKP....ILDALEPCLSFQRTGSCGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.50|      10|     610|      80|      89|       8
---------------------------------------------------------------------------
   80-   89 (18.68/11.55)	LHSLLKYSSI
  691-  700 (18.82/11.68)	LHSLVSPSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.67|      26|      27|     945|     970|      10
---------------------------------------------------------------------------
  945-  970 (44.42/26.92)	GAGPEVGEDDATNLTRIMGNAAAAVG
  974-  999 (46.24/28.31)	GVGQNMGGGLDTNIDDMLSAADMTVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17087 with Med5 domain of Kingdom Fungi
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