<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17084

Description RNA polymerase II transcription mediator
SequenceMIPHSSAGVQSWANSMRPLNSGPGRVEAPQALGQPSDPQPEKLPMSVPPSQPRQPAVIDLTSAGGDARDREPPAKRLRLDLSAASAARDGSPASGSTGEARSTPGTATSKPPALAWRGRPVWSFQALISETPGGSGGGSAAGGVEIKEEDATDVAQGGKVSPPPLPVLPWKYAPPQQAGANAAKSRDSSPSKAVQTTPYHIEVPTVAPAIKGDKVADFSPWSGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFSAALEKRQNHNMVNAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKSLLDQCLSKWIPVSRAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTATVQQFLEGVISVCGSSDWKLKMTYAVSLTARLFFERLLDHDQYLGWFLTSLETSSSNTVPVWLLMLGIYWDNIMRYRKRGRRLAEVLLAKLQRISKPEQVVPLRPLVDRLSLYIRRLVLEHTSSVILPKSWEKYKDLISSCLNMKDNVHKAIFQNLAERNARVQAPKCQQETTQRSPQQRVIHLFDSIRSTHEISSTSSECLKTIEDKSVLVSKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGVDIDSYILSFLAGTKTNPALNMENIYHIISELVRSQTFSVGRYLQWLMARGVTSDFHPDTRQAISNDLYLLKQLPTARLPEHVRNLRNTLLYRAGISAAEEESTIEEIKASVAQRLPKIFGTEMSSLMPSEPQSADLTWAVKSEIGQWMRRGISVHYRESQRKFSGHSFLSGSSVSALTPVEFYNVRDILESFGDLSILADVLKQATNCDDNIVLASVADTINYHFDSLCVIGATTDLFRGLVESYARIKRLGTPSLDLVFSLIELGLRLPNEFNTVALLRQDLSRIENRSALAAPSPLSDSIPPSFSEIDRTYQGKLDQILSSGSGMDESTMDTVFNSLTKTLTCSGGEGKLSANETCRYLAYLRPFHPKHFDSMLVRWICGLFKSSAQGIMSRILPPLIGVGCVTIHAFLLLVKRLMQSDRVTAVVPNLSDLRMDLLDLLVPPQPEQGRCFDLVTYRFYLAQQEFLLKHPEETLEVIRDAIILIEQREQETGPHSKRDNLEKCAISLLQVMLTQDPPVVVQYCLQKFLGQQNLSTAVLQKATDHLLGSDSSRGPQDIPEAERIILMTDDFSLPFCQLKLQMLFNVESGEASKNGIVDVMFNAAVKESRSKGTNWVGLVGLMSQDAVRQIRERAEKEFLSVPMFEDPPEQDTSKDKSSSLETAKLYLAIVEKLAYSIPETGVPSVVPVIVDKMDALLHRLVTMQTNFNSLTVNSRGASAAHLVQARLTFERALAFWFSALLRMVVMHRAAFSSGSSLAPKPHGVQEQTRLLISIFCVSLARLPDNVLRLFPAADYFPHRVPSEGYRPCPGILLQTHALDVAASLIDVFPDESRQHCARFLKEKCPPFIQYQNDLRFLYLLGPMNDAPPLNITQPASLPSPAGGGSTPTPTPSGSLGGGPSAQQPPTPAPTGMPSGVPEGVNCVASQLRLQYRGRTMGPYPVRPWELLEDAAPIVGVNDTAVNLKYFDARRVRA
Length1606
PositionKinase
OrganismAspergillus steynii IBT 23096
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.232
Instability index51.19
Isoelectric point8.94
Molecular weight177540.35
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17084
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.22|      14|      19|      54|      72|       1
---------------------------------------------------------------------------
   58-   72 (22.18/20.58)	IDLtSAGGDARDREP
   79-   92 (25.04/ 7.84)	LDL.SAASAARDGSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.97|      13|      16|    1520|    1532|       2
---------------------------------------------------------------------------
 1520- 1532 (29.06/14.86)	PTPTPSGSLGGGP
 1538- 1550 (27.91/13.94)	PTPAPTGMPSGVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      16|      16|     259|     274|       3
---------------------------------------------------------------------------
  256-  271 (26.85/16.68)	SLY.AQLKHRSGLQMLS
  272-  288 (23.31/13.55)	SVFsAALEKRQNHNMVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.55|      14|      16|    1142|    1155|       4
---------------------------------------------------------------------------
 1142- 1155 (24.89/17.20)	LQVMLTQD..PPVVVQ
 1158- 1173 (18.67/10.72)	LQKFLGQQnlSTAVLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.63|      16|      19|    1216|    1233|       5
---------------------------------------------------------------------------
 1217- 1232 (27.61/16.78)	FNVESGEA.SKN....GIVDV
 1234- 1254 (17.03/ 6.78)	FNAAVKESrSKGtnwvGLVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.71|      13|      19|    1389|    1404|       6
---------------------------------------------------------------------------
 1389- 1404 (19.10/20.02)	SLAPKPHGVqeqTRLL
 1411- 1423 (22.61/13.22)	SLARLPDNV...LRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.66|      16|      19|     323|     340|       7
---------------------------------------------------------------------------
  323-  340 (23.82/18.90)	LSRTIPhgIRGKSLLDQC
  341-  356 (30.84/16.97)	LSKWIP..VSRAVWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.09|      19|      21|     940|     959|      12
---------------------------------------------------------------------------
  940-  959 (27.25/29.14)	SEIDRTYqGKLDQILSSGSG
  963-  981 (32.84/28.41)	STMDTVF.NSLTKTLTCSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.84|      42|     171|      10|      57|      14
---------------------------------------------------------------------------
   12-   54 (76.22/40.44)	WANSMRPLN.SGPGRVEAPQALG....QP.SDPQPEKlPMSVPPSQPRQ
  164-  203 (50.55/21.25)	......PLP.VLPWKYAPPQQAGanaaKS.RDSSPSK.AVQTTPYHIEV
 1483- 1513 (36.06/ 9.94)	YQNDLRFLYlLGPMNDAPPLNIT....QPaSLPSP..............
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17084 with Med12 domain of Kingdom Fungi
Unable to open file!