<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17082

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDNASIVRAEQGTDARNGMSTSPGGTNQGAMPAGLNKSPAYTNGVSQGAGHGNREHKAPSTKFALRVNGRVPDLPHITQGFFPFSTLVNRSVQQCWNDLSDLITELAEIQIPSHDGNTLAIPANGKLSGNQSSENIQKKVRVLEFAHAKRAEFIKLLVLSQWSRQAADVSKLIDLQNFIRSRHQSYVSALQWIGDLKRNLVQAQVANPDLKTALEVLSKAKIMSMPDPGYKPPRPLTAKCTLKKLRKIDRILSARLSLCDIVPRPLQTFHIHDGRVTFIVLGEFELDLSIGEADESSQFYFVDIRFLFHPSASVPQGRMFNDLESKINDTLRNGGLTGCFDLLHSLVLTNKINILFKQALELARGLWSNVLRIELLHRTLVVHYWALKSGTKSWLEIGVKRGHRRSLGHSHGIPYLGLRWLRDGQEIDSADVEFDTVNLSMESALRSVIALHTSHILFSAHNILSQSFLFAAGMLNLQTQLTGIEPGDCQLDVQLTSSRYLRVSIEPMSGAIVLSARPSALERPEGERSPERTTADDIVSRVSRLRCIAAIEEIETHVRLLGFEPVNPRGLKIDVRRVFPVNVIRFSFFWHPFWERNWIVAATSSMDGDNWWVIQLLPPTSTEGPPTHDIGTLDQSMPRTAQIISRTLFPLQEQISYASFADIGHCLSGILAIYANARYMAGLQSFSFRPPLHKLALGSGFQVPDVYIRYNPASLPSSFQLALPGGSKTKGLIKDTIRLAFHGVEPRSKVAIMVAYGSLLIPAKAFSSLSTKWDRSLVFLRRGRGFAIRLLAPPGRPVIISLMENLQRLECVLSIFETLQRRRMAPQSLSLSRIAFAYGPERSLSSHIDIQTLSRTNADPADVSSQTHPMFYLHLSINFGCANPHRRIQGPLTSILNNSSADTSIDTVTELLSLTLPLMQAFDLTTTNRFHQEHLKMQVIVRNASTFIIHYPNQNVRFQLKSGGHKTQMVWILRDVNSPQDPSANKPLESDFKTRLFNSKGDGWKGLGSGVVAEAEKVGNFILELDRWLTSGRNNLATKYDLEAKAAGSGDSIQPRASEQAGSENTGNGPAMPAVPVTRMSNKNVPPETDAASGSSNADIIMID
Length1104
PositionTail
OrganismAspergillus steynii IBT 23096
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.188
Instability index51.55
Isoelectric point9.38
Molecular weight122288.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17082
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     388.55|     132|     434|     193|     429|       1
---------------------------------------------------------------------------
  255-  408 (187.05/304.22)	RLSLCDIVPRPLQTFHIHDGRVtFIVLGEFElDLSIgEADESSQFY.....FVdIRFLfhpsasVPQGR......MFN..DLES..KINDTLRNGGLTGcfdllHSLVLTnkiNILFKQALElaRGLWSNVlRIELLHRTlVVHYWALKSGTKS..WLEIGVKRG....HRRSLG
  738-  890 (201.50/107.68)	RLAFHGVEPRSKVAIMVAYGSL.LIPAKAFS.SLST.KWDRSLVFLrrgrgFA.IRLL......APPGRpviislMENlqRLECvlSIFETLQRRRMAP.....QSLSLS...RIAFAYGPE..RSLSSHI.DIQTLSRT.NADPADVSSQTHPmfYLHLSINFGcanpHRRIQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.44|      22|      68|     568|     589|       2
---------------------------------------------------------------------------
  568-  589 (39.94/32.28)	PRGLKIDVRRVFPV.NVIRFSFF
  638-  660 (34.50/26.68)	PRTAQIISRTLFPLqEQISYASF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      55.09|      15|      15|     151|     165|       3
---------------------------------------------------------------------------
  151-  162 (15.14/ 6.25)	....AEFIKLLVLSQW
  163-  178 (18.81/ 9.47)	SRQaADVSKLIDLQNF
  181-  192 (21.15/11.52)	SRH.QSYVSAL...QW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.66|      33|     477|     429|     461|       4
---------------------------------------------------------------------------
  429-  461 (55.33/36.17)	SADVEFDTVN..LSMESALRSVIALHTSHILFSAH
  900-  934 (52.33/33.82)	SADTSIDTVTelLSLTLPLMQAFDLTTTNRFHQEH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17082 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDNASIVRAEQGTDARNGMSTSPGGTNQGAMPAGLNKSPAYTNGVSQGAGHGNREHKAPSTKFALR
2) YDLEAKAAGSGDSIQPRASEQAGSENTGNGPAMPAVPVTRMSNKNVPPETDAASGSSNA
1
1040
66
1098










Molecular Recognition Features






MoRF SequenceStartStop




NANANA