<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17070

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPGGSITNIRAIDGFSSIYWRIYTEEPNIASIPGETPANGYTILRHLSRLKDLELRLRNANCLVSSYPRRLGLWVFSATPDFESLDPLCPNQGQEERSRLAVDSFTLKASGSGSTTAADLIKNLSTEPQTPGQNASASQRPTNGPPPARRMDGYASPGAIYAAFISAVTGALSLQLIRRDHAIPLGSRTLFTAIEGDDDESPRIANDDPASIPTLTTLHVQLTSVGKLMISLQTVAQDGITRLSQPDSALEDIVDAPRGTDLWLSPSGSVARLVSANPDPATAPSPYVTADAAGNDRSRSVHHKQWKLAVFDWLKCFGLPVRPINEMAWVEIEVWEPFYSRLAGETWRLGEDNTPTLPLKRILWPAIYCFRRSRAALSALVNPLCSSPSLHNDPLGFAEMWRTVEIPKPVERDPMPLSSHQDQPPKAETDPGELDFPEGIESLSRASQYPELQTASLVYPTPPDGAASLGVNPTNATDLFVEDSSFGSLPNQTKVGSLAQMPTGDSDVPMVFGPAAGLVVGSGLYDTNEDDLFGDLDEQDFGDKGITDADFNFFDDADFQGLGDGPPSHGTDEMTDLLGAEPDLSPTVSMQPPVESEQPSDRQAPAEPIETPQCSGTDQQVKPEEEEIGPRDNTTPPSSQNDNNQTISPPLSPVEVKKIILPAPDGNGRLPVPKGQKSYYKPVAFKQDMSNWDQKYGAAGKFWFKNAPSGADKSTNTDGDIPTIGLPRHTRNSVVSRDVAKTMDGHGSPSTEMAQDDQSSVTSEGSDESVSDSESSHADLPTLKRKRVRSNSPSTTAMSHGIAPVEDEQDSQGHRAEDAVFLGNLLSTFSDWSMTGYFSLPDNRLLPAIARREVQVQIAQLLSDQVTQTSLNHKLDGDLGLGDCGSKLYFLRTSLEDTPFVGGSERLDLSNYASLQDTNNFLSPPSGGLTPRQSSQRREAARGSISKLPSPHLRVRRGKDYLEVLPAAISFWETFGLEPAHGPKNITAYCIHPHTAADAAHVFLERLSLAYTSCNLGTHSRGNESNHFQHGLGKWVTTVTGGMGYPNVMMTLKTMCEEFGAVLTQGVPKEGNIVLYIVNPFTHATALADICAAFWSLFQQYAAAADTQQTRQLNELVLQIVPSDFMMSAESLVVPPQTQYLNLALEVYSRCHPKPLSTSLTGCAPPVLLADSIPRSINFRLAPEKSSPLQDGRCLHIACSRSQDQRWLGVAWTDTSGNLQRNISYCLRFRNASAYTAMSDIRNEIWKATREMLDRAQARWRVMLAYTDTVDQEEIDAWSGFIDQYSKSNAVSLELTIFAVNTTTDLSLEPPATPIPMSIFSSQPASTPVATPNPSGSVLSPEQSANAPTPPSGGGAAANAPTPTDAQIEAESESTLMDIGDETWGVILSHRLNNSPHLTELRPVLASGYLLRRRGAADGDGVYSMCVNLIHTTRPSQSYEGILRESLGMYRGLATLARARGTVTVQHSTLPWHVATAVRAQEVLSYVL
Length1490
PositionKinase
OrganismAspergillus candidus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.386
Instability index52.01
Isoelectric point4.95
Molecular weight161763.79
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17070
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     809.91|     181|     181|     395|     575|       1
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  395-  480 (108.82/47.58)	.....................................................................................................................DPLGFAE........MWRTVEIPKPVER....DPM..P.LS...SHQDQPPKAETD..PG.ELDFPEG...I.ESLSRASQYPELQTASLVYPTPPDGAASLGVNPT....NATD
  481-  660 (251.32/120.12)	LFVEDSSF.G....SLP...NQTKVGSLA...QMPTGDSD.VPMVFGPAAGLV....VGSGLYD.TNEDDLFGDLDEQDFGDKG.ITDADFNFFDDADF..QGLGDGPPSHGTDEmtDLLG.AEpdlsptvsMQPPVESEQPSDRqapaEPIetP.QC...SGTDQQVKPEEE.....EIG.PRD.....NTTPPSSQNDNNQTIS.....PP.......LSPV....EVKK
  663-  815 (176.56/82.06)	LPAPDGN..G....RLPvpkGQKSYYKPV...AFKQDMSN.WDQKYG.AAGKFwfknAPSGADK.STNTD..GDI..PTIGLPR.HTRNSVVSRDVAKT..MD.GHGSPS................................................temAQDDQ..SSVTS..EG.S.D..ES...VsDSESSHADLPTLKRKRVRSNSPSTTAMSHGIAPVedeqDSQG
  816- 1000 (211.42/99.81)	HRAEDAVFlG....NLL...STFSDWSMTgyfSLP.DNRL.LPAIARREVQVQ....IAQLLSDqVTQTSLNHKLD....GDLG.LGDCGSKLY....FlrTSLEDTPFVGGSER.lDLSNYAS........LQDTNNFLSPPSG....GLT..PrQS...SQRREAARGSISklPSpHLRVRRGkdyL.EVLPAAISFWE..TFGLEPAHGPKNITAYCIHPH....TAAD
 1004- 1091 (61.79/23.63)	VFLERLSL.AytscNLG...THSRGNESN...HFQHGLGKwVTTVTGGMGYPN....VMMTLKT.MCEE..FGAVLTQGVPKEGnIVLYIVNPFTHA....TALAD..............................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.11|      20|      55|      22|      42|       2
---------------------------------------------------------------------------
   22-   42 (33.40/20.96)	WrIYTEEPNIASIPGETPANG
   76-   95 (38.71/20.25)	W.VFSATPDFESLDPLCPNQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      12|      16|    1312|    1323|       4
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 1312- 1323 (24.80/13.44)	PPATPIPM.SIFS
 1330- 1342 (16.98/ 6.69)	PVATPNPSgSVLS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     242.20|      62|    1040|     325|     387|       5
---------------------------------------------------------------------------
  325-  387 (110.59/67.57)	PINEMAWVEIEVwEPFYSRLAGETW......RLGEDNTPTL.PLKRILWPAIYCFR.RSRAALSALVNPLC
 1202- 1236 (32.59/12.97)	.................SRSQDQRW.......LGVAWTDTSgNLQRNI...SYCLRfRNASA.........
 1363- 1428 (99.02/55.12)	PTPTDAQIEAES.ESTLMDIGDETWgvilshRL..NNSPHL.TELRPVLASGYLLR.RRGAADGDGVYSMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.10|      39|      55|     174|     217|       6
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  174-  215 (60.19/47.13)	LSLQLIRRDHAIPLGSRTlfTAIEgDDDESPRI................ANDDPASIP
  232-  286 (58.91/29.89)	ISLQTVAQDGITRLSQPD..SALE.DIVDAPRGtdlwlspsgsvarlvsANPDPATAP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17070 with Med13 domain of Kingdom Fungi
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