<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17065

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMEDDGINMEDLFGQTGSFDMPPPSPPPNKALSHRLDEMRLSGCCQKLAWSRQGCVAYVSADATKVNLRYLHCQPADGKWDLSDDNPSTLPMETSPGHVVVHLSWNELGSDLVVVESSGRVSIFTIGIALNAVNAYRPAVDPDDDSAQVVGMMWLNSQRSVHAFNQAAKVQGRWAYSPFRRRPIGPFSPVHKSALVCVTKSGIIRLIYQSPDNRWGEISAELKNTSYSDRLLTHAALSSTQGGVLLVTHSVCQKIGFYRVHINWTPPQYDPTQLKQAPVQFPAPTFRFSHVKVEAPGGVPGPLHGDHDRSDHLCPIPSALYCLTRLDIILAAQDNAAGSTANPWIVAIYSIPPHAASGLPQQSRPSTVIVRWQLDQAPHGLHPKFDEVASKKGPVQSKPKTVLRRLEDIQTDRYPISVDPTEYGNVVTVTFDDGSVAFYDPKTISPFSGVDDANTVTSLAQAGFHYPLDSACGLHIDFSPSGCLAATLNGDGQVQLRGMQHSYGVENEGYDENKFSAAVAALTLAFSRGCGSEVNTDDIIMLARRQLSPDAQLALVNEVYRALPINCDYTQEHEKQEKLMSNTYIPRCLSLQAALGFKDQFTSRSLASAIPWAILQIRHAAILYPFLFQYSKGVQGEPHDPDVLRTVLGNTRWALDFSHYLLNELFELADELEGVASDPETLSQKLKSTASLPLIILLSSMSRAYLRIICRGLRGIYTGYANAAFTGDSRIYYTEIRQTLDASPVRVDVYEKFVAGIDSAVRHAYHGAGFGDAERPGPEKELLVNARIPPVLVTAVGTIVRQTLGVIKPEVDRLAIYMADYSWLGVGGDRRGDGWRREREREVDVVRKMPLRITSTAAAAASGSQGNNGSGVGANQQNQQQQQQPPRRRRCVRCCGLSDGSTPLRTGPIGYRLIHRLGYVRQCVCGGLWALEAEPVVG
Length941
PositionTail
OrganismAspergillus candidus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.244
Instability index45.38
Isoelectric point6.61
Molecular weight103235.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17065
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.28|      26|     209|     691|     716|       1
---------------------------------------------------------------------------
  691-  716 (45.70/29.87)	STASLPL...IILLSSMSR.AYLR.IICRGL
  901-  931 (37.58/23.22)	SDGSTPLrtgPIGYRLIHRlGYVRqCVCGGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     266.33|      87|     209|     264|     356|       2
---------------------------------------------------------------------------
  176-  304 (114.83/82.06)	RWAYSPFRRRPIGPFsPvhkSALVCVTKSGIIrLIYQspDNRWGeisaelkntsysdrllthaalsSTQGGVLLVTHSVCQkigfyrvhiNWTPPQYDPT......QLKQAPVQFpAPtfRFSHVkVEAPGGVPG
  305-  400 (151.50/88.34)	PLHGDHDRSDHLCPI.P...SALYCLTRLDII.LAAQ..DNAAG......................STANPWIVAIYSIPP......haaSGLPQQSRPStvivrwQLDQAPHGL.HP..KFDEV.ASKKGPVQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.26|      50|      63|     737|     792|       3
---------------------------------------------------------------------------
  737-  792 (78.58/56.50)	TEIRQTLDASPVRVDVYEKFVAgiDsavrHAYHGAG...FGDAERPGPEKELLVNARIP
  801-  853 (85.68/47.76)	TIVRQTLGVIKPEVDRLAIYMA..D....YSWLGVGgdrRGDGWRREREREVDVVRKMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.97|      36|      40|     607|     645|       4
---------------------------------------------------------------------------
  607-  645 (57.58/52.41)	RSLASAIPWAiLQIRHaaILYPFLFQYSKGVQGEPHDPD
  648-  683 (62.39/44.77)	RTVLGNTRWA.LDFSH..YLLNELFELADELEGVASDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.00|      48|      57|     452|     499|       5
---------------------------------------------------------------------------
  452-  499 (84.52/51.31)	GVDDANTVT.........SLAQAGFHYPLDSACGLHIDFSPSGCLA.ATLNGDGQVQL
  501-  558 (68.49/40.20)	GMQHSYGVEnegydenkfSAAVAALTLAFSRGCGSEVNTDDIIMLArRQLSPDAQLAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17065 with Med16 domain of Kingdom Fungi
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