<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17063

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPTAGVPSWGPPPRAFNPSGARRPPDLSHSQSEMSTSMPQPLPRQPAVIDLTANVGDTQEREPPAKRPRLDLPVAAPSVGDRSPVPGSAGEARITPGVGSAKPPSFALRGRPVWSFQALVSEAPGAGDAREGDAAAVAQRGKRAEPPPFPVLPWQGPPPSSLESGGANSRDSPPSTVVQTTPYHIEVPPSAPVLKGDRIADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLHMLSSVFTAALEKRQSHNTVANPSTFKPPPRVTLTDNKREVWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLSKWIPVSRAVWLAKCVGANEIRAFKRKGTSGTLAVGLEAKWVRDWTATVQQFLEGVIAACGSADWRKKMTYAVSLTARLFFERLLDHDQYLGWFLTSLEVAPLNTVPAWLLMLGIYWDSILRYRKRARRLTESLLAKLHPISELDRTAPLRPLADRLSFFVKRLILEHTSSVVLLDSWDKYKDLISSCLDFNDNVHKAVFQTLAERNLRIQSPKSQQGLGQQSSQQRLIHLLDSINTTHDISASSAACLDAIDDRGVVVSKLLEWTATSFRYGICRVYTAVRLLRKWKASGVDIDSHILDFLNGDRDSDSLNMSNIYHVISELVRSQTFSVGRYLQWLMAKGVAADHSEPRQPQQSEALGLLLQLPTGRLPEHVRNLRNTLLTRAGISASQEESTITSLKASIAEQLPDVFEAQMLGVTMAEMSPNDLTWAVKSEIGQWMRRGVTGYTRESHRKIPGASWATEARVCALNPDQFYRVRSILESFEDLSMLADVLKQASNSEHSVVLASAADTVSYHFSSFSAIGAVADLFKGLVESYSCLKRVGPPNLDLVFSLIELGLQMPNELNTVALLRQDLCRIENRSALTAPSPLSDHAPLAFNPMDSAFQEKLDQLLGPNGGIDESTMDTIFSSLTKILGSVDGQPRLSANDACRYLAQLRLFRPKHFDGMLVRWICSLLRSPTRPALAQILPPLIGVGCVTIQAFVFLVKRILQSDKVATAFPNLADLRIDLLELLIPSDSFEPSSHPDLVTYRFHLAQREFIAKHPRETFDIVRDAISLVNSHHGQVNPRRVDLTNCAMSIVHILLTQDPERAVKYCMEKFVDHPSSTGVLQQALDRLLRFDSGPERPAEKVVDMNDDFSLPFCQLKLQIMFNAEPGNSANNGIVDAMFSAAVADSRANRSHWVGLVSLMSLDAVRQIRERAEKAFFAIPMFEDPAHDSTADRASSPEIAKLYLTIIEKLAFSVPETGVPSAAPILVEKMDLLLHRLVVMQNNFLGSAANKQGSGSEQMVRARANFERTLAFWFSALLKIVVIHRSSFVTSSLTARPTLIQEQSRLLISIFCISLARLPDNVLRLFPAADYFPHPVLSEKHRPCPGILLQTHALDVAASLIDMFPDEARQHCARFLKEKCPPFIQVQANPRVPYLLGPVPDVAANAPQPASLPSPSPVAGGSTPTPTPIPSGNFTPGPAVPQQQIPAASIPPGLSEGANYIAGQLRLQYRGRVVGPYPVRPWELLEDAAPIVGVNDTAINLKYFDARRVRA
Length1587
PositionKinase
OrganismAspergillus candidus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.175
Instability index50.29
Isoelectric point8.75
Molecular weight174907.15
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17063
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.59|      14|      15|    1483|    1496|       1
---------------------------------------------------------------------------
 1483- 1496 (26.94/ 9.22)	PQPASLPSPSPVAG
 1500- 1513 (28.64/10.25)	PTPTPIPSGNFTPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.54|      12|      15|    1197|    1208|       3
---------------------------------------------------------------------------
 1197- 1208 (22.92/15.24)	MFNAEPGNSANN
 1214- 1225 (20.63/12.89)	MFSAAVADSRAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     274.07|      73|     218|     114|     189|       7
---------------------------------------------------------------------------
   10-  111 (101.56/43.03)	PSWGPPPRAFNPSGAR...RPPDLSHSQSEMSTSmpQPLPRQPAVIDLTAN..VGDTQEreppakrprldlpvaapsvgdrspvpgsaGEARITPGVGS.AK.PPSFAL.
  112-  155 (73.82/29.38)	..RG................................RPVWSFQALVSEAPG..AGDARE.............................GDAAAVAQRGKRAE.PPPFPVL
  156-  197 (64.60/30.12)	PWQGPPPSSLESGGANsrdSPPSTVVQTTPYHIE....................................................................vPPSAPVL
 1522- 1556 (34.10/ 9.25)	.....................................PAASIPPGLSEGANyiAGQLR...................................LQYRGRVV...GPYPVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.62|      11|      16|     727|     737|      11
---------------------------------------------------------------------------
  727-  737 (17.96/11.68)	LKASIAEQLPD
  744-  754 (19.66/13.61)	LGVTMAEMSPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.44|      60|     408|     880|    1022|      15
---------------------------------------------------------------------------
  947- 1022 (88.26/159.22)	IDESTMdtIFSSLTKILGSVDGQPRLSANDACRYLAQ.....LRLFRPKHFdgmlvrwicsllrSPtRPALAQILPPLIGV
 1359- 1423 (102.19/37.43)	IHRSSF..VTSSLTARPTLIQEQSRLLISIFCISLARlpdnvLRLFPAADY.............FP.HPVLSEKHRPCPGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.92|      12|      15|     243|     255|      16
---------------------------------------------------------------------------
  243-  255 (17.74/18.56)	SLY.AQLKHRSGlH
  259-  271 (16.18/ 9.89)	SVFtAALEKRQS.H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.17|      38|     226|    1048|    1088|      17
---------------------------------------------------------------------------
 1048- 1088 (56.87/33.89)	PNLADLRIDLLELL...IPsDSFEPSS......hpDLVTYRFHLAQREFI
 1273- 1321 (52.29/27.03)	PEIAKLYLTIIEKLafsVP.ETGVPSAapilvekmDLLLHRLVVMQNNFL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17063 with Med12 domain of Kingdom Fungi
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