<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17053

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDSFSLPLRPRLDRPDPPDPLPVEIAQINTQWGSFRHVSEDFLRRRIADQSDDASDDHDEDESPTEVDATERLDQLYRKRAEITQFAHQAHMEALFALDFVSLLISQHAPRQAETSMSAYLKQVAPMGSLTPEVVDPPPKPDAVRRDTEAVSRGWRLQNFNSAANKLLNAASRLESEVAAETRYWNEVLSIQNQGWKVCRLPRDRQALGVQYGFLEATPIFRDRGLASLRRADDGSLLLNQGLVPQKARRVRVRVKTDDRWTGASRTPPPPTSDADAIEARIRQARDTVYEEELFHEMTREARILAPHGVTTRQNLVRVPVSDVQEIWLDLVDTDGDSSPPADPETTAEDDRLADALSHALRILLAHAHRQNRHRREQPPPPLTPRRRHTPEYHILRPLLAGLQHRAHVRALEAVLGDLHRVRRAAGLPGDGTVTPFASVRPPASHPGVPAVESLVRTLLRPLESTLGGPLAAPQASIHVTVRTTVAGPPGGTVFDLAVHLPAFPDVQPPARISLRSEAEAVLSHVLLLDVVAAVAAAPAVPPARRWEPAAPHHGELITAGGPSAKNRKLTVHLSRDALRVEAVAVGGLDPFGRPTPDPTATPRSRTWTAESTGTGLMDFVGEVSQE
Length628
PositionHead
OrganismAspergillus candidus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.05
Grand average of hydropathy-0.456
Instability index53.68
Isoelectric point6.31
Molecular weight69117.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17053
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     275.13|      55|      58|     380|     435|       1
---------------------------------------------------------------------------
  269-  306 (55.98/20.14)	P..PPPTSD..AD..AIEARI..R......QARDTVYE.EEL...........FH.EMTRE.ARI.....L
  380-  435 (99.23/43.76)	P..PPPLTPRRRH..TPEYHIL.RPLLAgLQHRAHVRALEAVLGD........LH.RVRRA.AGLPGDGTV
  437-  495 (49.21/16.91)	P..FASVRPPASHpgVPAVESLvRTLL.........RPLESTLGGplaapqasIHvTVRTTvAGPPG.GTV
  506-  558 (70.71/27.17)	PdvQPPARISLRS..EAE.AVL.SHVLL.LDVVAAVAAAPAV.PP........AR.RWEPA.A..PHHGEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.07|      20|     119|      14|      33|       2
---------------------------------------------------------------------------
   14-   33 (38.57/16.83)	DRPDPPDPLPVEIAQINTQW
  137-  156 (37.50/16.17)	DPPPKPDAVRRDTEAVSRGW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17053 with Med17 domain of Kingdom Fungi
Unable to open file!