<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17037

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDSSSLTKISPIESAVTNVLTVSNIIKVGWCKYTYSCSGDQLRSFITSTPSSEVENISRIDDPIVVNYMVLLEKGIPCTWKYKDENEKNFEILFTDKMLVRELYVFWLEDAEEHPSTLDNLTRLEGLEVTEKGTFTWEDFESSAIQFDLFIRSIKNLISRTLIGKGAVPMGELHLFPKFQQKIYECILSCKYNIHITSTNLVVKPVVRYQSLRPLAPSDFSKSEEVKLEVVKVLLAPSGIRGNLLPYRRYEADDIAAVLNEFRTLFGLDLSNLEEESSIPTLVHVQITHDNLTKDFPYPAKGVYVITDSNNIYRCEARDSGMVPEIFNNFVDYSSEQKLKPSKWWSYNDHSKEAVQILKLRNSVDLGTTSPGVDTMTPNTPGMGNGTSSASSPGHNLGTGRSSKKRPLETKAYPSPPDAIQSNEIQMPPPQNDAELTDEIMGMDVGSYEFDYYMYDDITDADFDNCDNKDSQAISPTTNDQTPGNISIVNEDSPSVGQNQISLAKHRQQQIDRDLQFEIGKVKLRYCPEDYTPLMFHNEVDMTKYMPGGKFCRATNRKKRKRGFFYTPDYEPAWVLEAKKPKTSDDDLKPSQKRKEEELEYYSSESDIDYTSESCESESESDIESNDESEVEWKNEIGNSKVSNHRELGFLNAGRLSMIFNIYVLCERRQLRRLTDCEVCNDTQSEMALQFLREQIAGGSYPFGAGIHGEGESTFEFIETRRRILENLSDDLPTSSALPSEQQEITMSLKNVIEKISVKFPRPENHPQLSVNGPLSVQDYYNLNGVQFKINEGVESNFQVLKTPDIIVCADKFLIETSPEIVKYWDKHNLTPFAGKKDVKYFVFCPEGDSLYYHVKNFFNELRVQYELHCVLGMHEPGIIQNPNYNFKQGIIPIRLKPQNRNETELDRMIRSYKSTCEEFGSSLASHIANFEKTQLVIYLINPFNHLTAYYDIFKCYAKFYTSLEKSLKSVSTKNILNYVMPQLIPIEHVVRFGENCIRPFRQRPVLKDLAFSVYTRSKSYRPLFILPKPSVVSVGFQLIKKAPPVRELIEYNKILHMSYGFSFDQRRLVMVWVDMEGKKLGSYSTPTYESKNQISLESLYKETWSRTCAFNKHIGGYKQIIITKTGVMTQEEKNLWIKVTEGKVPIFSVNLDTTLDIKPTLDGNGQSSKICGMVLNHPIPVNDFRPEATGFLVEVNNNETVSNTIQVDLLYNPKNEKKNTEIMWDVLNQFHRMIYSYL
Length1239
PositionKinase
OrganismRhizophagus irregularis
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.10
Grand average of hydropathy-0.482
Instability index47.83
Isoelectric point5.49
Molecular weight141924.21
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.19|      81|     109|     809|     898|       1
---------------------------------------------------------------------------
  809-  898 (123.75/111.86)	CaDKFLIETSPEIVKYwDKHNL.....TPFaGKKDVKYFVF.CPEgdSLYYHVKNFFNELRVQYELHCVLgmhePGIIQNPN.YNFKQGII.PIRLKP
  917- 1005 (125.44/82.05)	C.EEFGSSLASHIANF.EKTQLviyliNPF.NHLTAYYDIFkCYA..KFYTSLEKSLKSVSTKNILNYVM....PQLIPIEHvVRFGENCIrPFRQRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.42|      31|     780|     422|     455|       5
---------------------------------------------------------------------------
  422-  455 (47.60/45.57)	SNEIQ...MPPPQNDAELTdEIMgMDVGSyEFDYYMY
 1203- 1236 (54.82/35.44)	SNTIQvdlLYNPKNEKKNT.EIM.WDVLN.QFHRMIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.88|      26|     593|     498|     523|      11
---------------------------------------------------------------------------
  498-  523 (45.26/30.24)	QNQISLAKHRQQQIDRDLQF..EIGKVK
 1092- 1119 (43.62/28.88)	KNQISLESLYKETWSRTCAFnkHIGGYK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17037 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNCDNKDSQAISPTTNDQTPGNISIVNEDSPSVGQNQISLAKHRQQQ
2) LGTTSPGVDTMTPNTPGMGNGTSSASSPGHNLGTGRSSKKRPLETKAYPSPPDAIQSNEIQMPPPQNDAELTDEIM
464
366
510
441










Molecular Recognition Features






MoRF SequenceStartStop




1) EPAWV
571
575