<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17027

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNATVGRPGHAPDTQTPSNGDNLRNGSLHINGAAKGTKEHDPDKESYIGKPGIDGHRALPELPHITQGFFPFSTLVNRSVQQCWNELSDLITELAAIQVSPHSSMPLLPVNGKTPGNQSPENVQKKLRILDFAHAKRAEFIKLLVLSQWSRRARDVSKLIDLQNFIRARHQAFVDALQRVGDMKRDLVQAQVANPDLQTALEILSKGRLESLADLGYKSSKLLTARGALRRLHKVNRIISARLALHDSIPHPFRTYRVHDGRVTFVVRGEFELDLSVGAESELSQFFFVDIRFLYSPSSSIPKGRMSNEIDAKINDKLRDSGLTGCFNFLHGLVLTNKIHILFKQAIELAKGLWSETLRVELLHRTLVVHYWALKPGPKSWVEIGVKSGNGDADSQGFGVPCLGLRWMRDRQEVDSRDIEFDPEDLSMECLLRSVIALHISYLLSSAYGILSEHSLFSTGTLSSQAILNVTEPGECQLSVQLTDSRHLRVSIEPMSGAVILSATPGVSERSESDAILDRSTIDDLVARVSRLRCIAAIEELESNVRILGFETVSPKGLRNDIRKAFPANVLRFSLFCHPSWERNWVVAATSSITGDNWWVVQLRRSSEVATDFSVSDTSVPLCSGYSMSDTFLATSHQTHSSSFPDLGYCLSGMVAIYANVSYLSDLQSVEFHPPLCALKVESDLQIPDIFIRYQVSNLPRALQLVLPAGLKRKNLLKDTVRLAFHGIDRHKNIAIFVAYGNLVGPWTDLCTLVSKSDSSLVFKRGGSGFALRLLAPPGRPVIVQLFKSLQTLECTLSILDFLRQRRLTPQSLSLTHIAFAYGPRRDLSAIIGIGLSEVPSSAELDPVRILARTDPLLSLTLGIRFKHPNPHRRVQGSLAAILNHASNEAGLDFVTEILSFTLPLVRALEQLTSNASRQESFRLQVIVRNAYTFLLHYTYQGFRFQLTTSQHSGQLTWVLRELSSPGAGPGHDQLKAKLRGTLYHSKGNGWKGLGNGVVADAEGVSNVIWALDGCFTGAQHNTWLPRETKSDQDYSTQPVPEKQSQTGAPSQAGMANDTTMTANFVNDKSLQRNPVASNAADVITID
Length1093
PositionTail
OrganismAspergillus novofumigatus IBT 16806
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.152
Instability index46.79
Isoelectric point8.68
Molecular weight120762.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17027
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     354.01|     117|     180|     657|     785|       1
---------------------------------------------------------------------------
  657-  785 (187.75/118.35)	LSGMVAI.YANVSYLSDLQSVEF...HPPLCALKVEsdlqipdifIRYQVSNLPRALQLVLPAGLKR..........KNLLKDTVRL..AFHGI....DRHKNIAIFVAYGNlvgPWTDLCTLVSKSDSSLVFKRGGSG...FALRLLAPPG
  834-  973 (166.26/86.50)	LSAIIGIgLSEVPSSAELDPVRIlarTDPLLSLTLG.........IRFKHPNPHRRVQGSLAAILNHasneagldfvTEILSFTLPLvrALEQLtsnaSRQESFRLQVIVRN...AYTFLLHYTYQGFRFQLTTSQHSGqltWVLRELSSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.90|      31|      47|     444|     475|       7
---------------------------------------------------------------------------
  444-  475 (47.67/33.50)	LHISYLLSSAYGILSEHSLFSTGTlSSQAILN
  494-  524 (51.23/31.69)	LRVSIEPMSGAVILSATPGVSERS.ESDAILD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.63|      11|     687|     133|     143|       8
---------------------------------------------------------------------------
  133-  143 (19.92/11.84)	LRILDFAHAKR
  803-  813 (19.70/11.63)	LSILDFLRQRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.69|      63|     203|     322|     398|       9
---------------------------------------------------------------------------
  322-  398 (88.38/89.96)	DKL..RDSGLTgCFNFLHglVLTNKIHILFKQAIElAKGLW........SETLRVELLhrtlvVH.YWalkpgPKSWVEIGVKSGNGD
  529-  602 (94.31/58.09)	DDLvaRVSRLR.CIAAIE..ELESNVRILGFETVS.PKGLRndirkafpANVLRFSLF.....CHpSW.....ERNWVVAATSSITGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.13|      14|     687|     300|     316|      12
---------------------------------------------------------------------------
  106-  127 (22.85/ 7.68)	SPHSSMPllpvngktPGNQSPE
  302-  315 (27.29/13.37)	SPSSSIP........KGRMSNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17027 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMDNATVGRPGHAPDTQTPSNGDNLRNGSLHINGAAKGTKEHDPDKESYIGKPGIDGHR
2) PRETKSDQDYSTQPVPEKQSQTGAPSQAGMANDTTMTANFVNDKSLQRN
1
1032
63
1080










Molecular Recognition Features






MoRF SequenceStartStop




NANANA