<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17026

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSNIYWRIYTEEPNIATLSGDSPTNGFTILRHLSRLKDLELRLRNLDCLVSSYPRRLGLWVFSATPDFESLGPLCSNGTSDDPSKLFVGSATLKVSASGSVTSKELVKNLSSEPVNAATNPQGVQRRQNGPNPPRRADGHGSSAAIYASFISAVTGALSLQLIRCNNAIPLGSRTLFTVVAEDYYDNPRVDNDNPAAVPSLTTLQIQLTSVGKLTVSLQTISQPGILRLCGPYDTSVGVHNAHLGCDIWLSPSGSIARLVATHSDSQNASSGHTMANPPNTSKLEEWKALVVEWLGNYGLPLISSEEGPWVEVEVWEPFYSRLAGETWRQNEEGASVLPLKRILWPARYCFTRKKPTSLDPLLGINDTFPVIDEPLGFAEKWFGMAQLDHEEIDSKPASRPEPETKDQETPLSRPDLPESIESLSRAAEYPDLQASNLVYPTPPDGAFPVGPNAPPASDAAAEDLDSRHLTNRALAKVKTKEGASARERSDHDVLMSFGPSPGLIVGSGLYDTNDDDDLFGEINQRDFGSKGLTEADFSFFDDPEFNHLSGDVNEMDVGAQETPEIAVDAEEPKPQPLPLEQPLTDNLLPGQRDTTEQADTNLARPEEEISNPQPADVPLSASMQISSPPPLSPIEVKKTLFAGPHEDSQLSVKNGHLQGHYNPVAFKENVLDWDQKYGAEGKFRVTGAVVNNYLVPTSTTSDIPTIGLPRRNARTKNPQGPARDNDKPRSPASDLDQPMPSDSDFDSTSDTSDDSDGNLSNSDESVATFVTRKRKRARSYSGSSVNLPQEKPLARSEQSIATSRTDDLVFLGNFLSTFSDWSMTGYFSATQKQLAPVLIRKDAQIQVAQLLVDQVTQSCLYHKVDGILGVSEFESKAYSLRTFLEDTAFMGEIERLDLNGFVSLQENSGLSPPSTATMSRQSSQRKENGKSSMSKLAPPHLRIRRGKDYLEVLPPAISFWETFGLEPAYGSKDISAYCIHPQIAAEAANDFLERLGLLYSSCNLGQHTRASRSTGFDRGMCSWNIGAPGEFTYHYIMQSLKSICDKLVTALLKSPPTKHTVVVYIINPFSHAAALADICSVFWGLFQKYTDEVEKQQAGQANELALQIVPFHFIMSTESLVVPPQAQYLSLALEVYSRCPPKSLQSCLLNCAPPMLIAEPVPKTINFKLAPDRSSPLQEAKSLHIACSKSYDQRWVSVSWTDNTGTLQRTMSYCLRFQNSNAARNILEVRNEIWAATKIIMEKTQARWKIIIANTEPVDQDEVDTWTSLVEQYNMTKPFLSDLTILYVNTTPDLYLEPPPQPLPMSVFNPQISSTPVATPNPSGNAFSPEQSGNAPTPPSGGNAPTPTEIPPDAESECLLTDICDESWGVILSHCLNSSPHLTDYRPALASGYLLRRKGPTDADGAFAMNVNLIYSQKPPSSYENLLREIIARYRDLATLARARGTRTVQQNTFPWHIATAVRAQELLSYIL
Length1489
PositionKinase
OrganismAspergillus novofumigatus IBT 16806
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.395
Instability index52.41
Isoelectric point5.05
Molecular weight163504.43
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17026
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     404.61|     119|     277|     124|     288|       2
---------------------------------------------------------------------------
  124-  246 (184.82/95.14)	KNLSSEPvNAATNPQGVQRRQNGP..NP..PRRADGHGSSAAIYASFISAVTGALSLQLIRCNNAIPLGSRT..LFTVVAEDyYDNPRVDNDNPAAVPSLTTLQIQLTSVGKLTVSLQtiSQPGILRLC
  407-  524 (168.37/74.26)	EEIDSKP...ASRPEPETKDQETPlsRPdlPESIESL.SRAAEYPD.LQASNLVYPTP...PDGAFPVGPNAppASDAAAED.LDSRHLTNRALAKVKTKEGASARERSDHDVLMSFG..PSPGLIVGS
 1351- 1397 (51.42/10.46)	........NAPTPPSG....GNAP..T...PTEIPPDAESECLLTDICDESWGVI...LSHCLNSSP..............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.70|      14|     410|     247|     260|       3
---------------------------------------------------------------------------
  247-  260 (27.74/16.67)	GPY.DTSVGVHNAHL
  660-  674 (22.96/12.50)	GPHeDSQLSVKNGHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.59|      14|     277|    1152|    1165|       4
---------------------------------------------------------------------------
 1152- 1165 (28.19/13.18)	VYSRCPPKSLQSCL
 1431- 1444 (26.40/11.90)	IYSQKPPSSYENLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.33|      14|      15|     942|     956|       7
---------------------------------------------------------------------------
  942-  956 (21.35/16.40)	RKENGKSSMSKLaPP
  959-  972 (25.98/15.27)	RIRRGKDYLEVL.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.43|      13|      15|    1309|    1321|       9
---------------------------------------------------------------------------
  580-  595 (21.18/ 9.03)	PEIAVdaeEPKPQPLP
 1309- 1321 (27.69/14.62)	PDLYL...EPPPQPLP
 1327- 1339 (23.55/11.07)	PQISS...TPVATPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.22|      14|     209|     800|     813|      14
---------------------------------------------------------------------------
  800-  813 (25.66/13.63)	SSVNLPQEKPLARS
 1017- 1030 (26.56/14.37)	SSCNLGQHTRASRS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17026 with Med13 domain of Kingdom Fungi
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