<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17022
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNVEFQTALSNLEDKLNALITNLTTSPTASGAPAAALALLDADDSLTSAIETLRRHQENYARILKLRAEAESLEEKVKGVVRDVVGYEKDIRKICGDDEPSDSDADDFSDDDDLDYGGDQTQTKPDRLRKTKEIDYRLLLDFARRISKYNHQAAADAAANATQAAKARGRSPQPGDQDMAMTGVNGGPGAEEGAEPVSSVTKEATSWLDESAKMTRQVYMIPYPMEDRIRMGLMGQIQLTAAEGRPGFDPDLEVERLIREAEGLGSTEPVVPAPQPMGEERRHANEAARAAAQAGAASSGTTAAAAPAPKPKATLDLDLYDPDDDEMM |
Length | 328 |
Position | Middle |
Organism | Aspergillus novofumigatus IBT 16806 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.636 |
Instability index | 40.68 |
Isoelectric point | 4.52 |
Molecular weight | 35364.76 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP17022
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 370.66| 128| 134| 46| 179| 1
---------------------------------------------------------------------------
46- 179 (193.00/109.53) LTsAIETLRRHQENYARILKLRAEAES.LEEKVKgVVRDV..VGY..EKDIR.KICGDDEPSDSDA.DDFsdDDDLDYggDQTQTKPDRLRKTKE.IDYRLLLDFARRISKYNHQAAADAAANATQAAKARGRSPQPG...DQDM
181- 319 (177.65/85.79) MT.GVNGGPGAEEGAEPVSSVTKEATSwLDESAK.MTRQVymIPYpmEDRIRmGLMGQIQLTAAEGrPGF..DPDLEV..ERLIREAEGLGSTEPvVPAPQPMGEERRHANEAARAAAQAGAASSGTTAAAAPAPKPKatlDLDL
---------------------------------------------------------------------------
|