<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17005

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMENNNWRPAQGETPSMEVSSSDWRSQLQPEARQRIVNKIMDTLRRHLPVAAPEGMTELKKIAVRFEEKIYAAAVNQSDYLRKISLKMLSMETKTQQNAPMNPQPGVNQNSTDTGSLAIPPHVNSQGQPLPQIPLVGPPSGRQQLLPQNLQNNTPASMQGSSSLSAAPSITGLSQSTITNFGHTSNMQNMPGISHSSVNNSLAQGTTADIYANAPRHMQGRQQQQSQNPLIYQNSLQPQLMKKIHNNAVLQRSMQQQQQQQSLLQTNQLQTSQQSTMQMPSGLTSGQSSIQQPPATSIQSASQPDLQQNQLNAIQQSVSPLLPQHVQAFSRQSQQPQSSLHQQTNLQTQQQQQQQQQLIGQQANMSNIQQNQLLGQQNSIVDIKQQQQRLPVQQNNLINMQQSQQLLNQQSLSLHQQQLGQQTNMQGLQQQQQPQSQQQQQLLGSVQNISNMQSHQRSMQLLQQSKNMSQAQQQLQQPSISLLQPQGQQTLHLSSQQHLMPQFQPQGQLQQPLAMQQQSNGGMQREIQQRISSGTLLQPQSALEQQKQFMQSQRGIPEVSSSTSMDSTAQTGHNGADWQEEVYQKIQVMKEEHLAELQEFHLKISQRYQQSEMMPQAKQSGNFEKLKSFKVFLERVLAFLQISKNSITIGLKEKLPTYEKQILGLLNANNKQKIMPSQLQGQQQLHHPGGLAQSTTQHQPSQVLQVQQHENLGNQVHQMNMTGSITSMQSAVTSSMQHGSMTLPSLVAPLTQQNATNSAQSAPDLDPVQVNSFGSLQQGTMGSLQQSAVGPLPNSVSASQQTNLNNLSQSSLNSLQPNGTSVQNSNVLQQQHLKQQQQEHLLQNQQQLKQQLQQHQMQQQLLQQQQRLQQPLQQQVHQQQKQQQPSQLPVHQMSQLHPINELNELKARQGSSIKPGIYQQTFTGVQRPNYYPHQLKPGASFPISSPQSLQASSPQISHHSSPQIEHALLPTHAKPGTPMQSTGSPFVVPSPSPSTPIAPSPTPGDSEKLLSAAVSLPTTRQTTNQQAASAPLQSQSISVATPGISASPLLAEFPSQEGNLTNATSRVGASERPLERLIKAVQSMSPTALSSAVSDISSVVSMIDRIAGSAPGNGSRTAVGEDLVAMTKCRLQARNFMSQDGSTTTKKMKRHTSAMPLNNVSSAGSVNDNFMKFGSLDSPELESTATSHVKRRKLEEEIREINQQLIDTVVSICDENSDSAAAAAAASEGVGEGTIIECSFNGVAFSPSLKAHFASMHMCPIAPLRLLVPSNYPKCSPLLLDKLPIESSKEFEDLSIKAKSRFSISLRGLSQPMSLGEMAGTWDACARKVIVEYVQKTGGGSFSSTYGAWVNCVGA
Length1354
PositionTail
OrganismDendrobium catenatum
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Epidendroideae> Malaxideae> Dendrobiinae> Dendrobium.
Aromaticity0.03
Grand average of hydropathy-0.679
Instability index72.22
Isoelectric point9.26
Molecular weight148635.95
Publications
PubMed=26754549
PubMed=28902843

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17005
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     376.71|      53|      84|     350|     432|       4
---------------------------------------------------------------------------
  257-  320 (60.31/11.58)	QQQ.Q.S...LLQT...NQ........L...QTSQQSTMqmpsGL..TSGQSSIQ.Q.PP................ATSIQsasqpdlqQNQLN.....................AIQQS.VSPL
  350-  406 (56.14/10.23)	...........................Q...QQQQQQLI....GQ..QANMSNIQ.Q.NQLlgqqnsivdikqqqqRLPVQ........QNNLI.....................NMQQS.QQLL
  422-  461 (61.68/12.02)	TNM.Q.G...LQQQ...QQ.......pQ...SQQQQQLL....GS..VQNISNMQ.S.H..........................................................QRS.MQLL
  465-  528 (55.07/ 9.88)	KNMsQ.A...QQQL...QQpsisllqpQ...GQQTLHLS....SQ..QHLMPQFQpQ.GQL.............qqPLAMQ........QQSNG.....................GMQREiQQ..
  733-  791 (48.69/ 7.82)	SSM.QhGsmtLPSL...VA.....pltQ...QNATNS.A....QS..APDLDPVQ.V.NSF................GSLQ........QGTMG.....................SLQQSaVGPL
  792-  861 (49.45/ 8.07)	PNS.V.S...ASQQtnlNN........L...SQS..SLN....SL..QPNGTSVQ.N.SNV................L..Q........QQHLKqqqqehllqnqqqlkqqlqqhQMQQ...QLL
  862-  926 (45.36/ 6.74)	QQQ.Q.R...LQQP...LQ........QqvhQQQKQQQP....SQlpVHQMSQLH.PiNEL....nelkarqgssiKPGIY........QQTFT.....................GVQR......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.80|      28|      28|     952|     979|       5
---------------------------------------------------------------------------
  111-  136 (34.47/ 8.53)	TDTGSLAIPPHVNSQGQP..L.....P.QIPLVG
  137-  167 (29.30/ 6.07)	PPSGRQQLLPQNLQNNTPasMQ..gSS.SLSAAP
  531-  559 (34.30/ 8.46)	SSGTLLQPQSALEQQKQF..MQ...SQrGIPEVS
  960-  990 (38.73/10.56)	SPQIEHALLPTHAKPGTP..MQstgSP.FVVPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.25|      22|      22|    1027|    1048|       6
---------------------------------------------------------------------------
  938-  959 (23.40/ 6.52)	ASFPISSpQSLQASSPQISHH..S.
 1004- 1025 (24.66/ 7.29)	DSEKLLS.AAVSLPTTRQTTN..QQ
 1027- 1048 (37.91/15.37)	ASAPLQS.QSISVATPGISAS..PL
 1050- 1073 (27.28/ 8.89)	AEFPSQE.GNLTNATSRVGASerPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.26|      21|      22|     660|     681|       7
---------------------------------------------------------------------------
  663-  687 (24.86/11.46)	GLLNANNKQKiMPSQ.LQGQ.qQLhhP
  688-  711 (28.40/ 9.73)	GGLAQSTTQH.QPSQvLQVQqhEN..L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.59|      16|      17|     223|     238|       8
---------------------------------------------------------------------------
  223-  238 (28.75/12.24)	QQSQNPLIYQNSLQPQ
  241-  256 (26.83/10.84)	KKIHNNAVLQRSMQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.69|      16|      22|     171|     190|       9
---------------------------------------------------------------------------
  171-  186 (29.48/10.08)	GLSQSTITNF...GHTSNM
  191-  209 (22.21/15.01)	GISHSSVNNSlaqGTTADI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.27|      40|     107|    1095|    1135|      10
---------------------------------------------------------------------------
 1095- 1135 (64.88/50.15)	ISSVVSMIDRIAGS............APGNGSRT.AVGEDlVAMTKCRLQARNF
 1159- 1198 (28.02/15.08)	VSS........AGSvndnfmkfgsldSPELES.T.ATSH..VKRRKLEEEIR..
 1205- 1244 (55.38/37.51)	IDTVVSICDENSDS............AAAAAAASeGVGEG..TIIECSFNGVAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.62|      22|      22|      47|      68|      11
---------------------------------------------------------------------------
   29-   51 (29.97/18.03)	PEARQRIvNKIMDTLRRHLPVAA
   52-   73 (34.65/21.92)	PEGMTEL.KKIAVRFEEKIYAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.68|      14|      22|     575|     588|      13
---------------------------------------------------------------------------
  575-  588 (23.96/18.87)	ADWQEEVYQKIQVM
  615-  628 (17.73/11.31)	QAKQSGNFEKLKSF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17005 with Med15 domain of Kingdom Viridiplantae
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