<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17004

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVEFSNLVRRAAEESYLSLKELVETHKSPQERSDSEKKIDLLKFIVKTRQRMLRLHVLSKWCLQVPLIQYCQQLSATLSSHDTCFTQTADSLFYMHDSLQQARAPIFDVPSAVEVLLTGGYNRLPKCIEDLGFQPALSDDLQKPALKKLEMVLRSKLLDASIPKEISEVKISNGTAVLIVDGEFKVFLTLGYRGHLSLWRILHLELLVGEKGDPIKLEETRRYVLGDDLERRMAVAEKPFMILYNILHELCVSLVMDTVLRQVKILRQGRWKDAIRFELISDGISGHGVNTSATQMAQDAELDSTTQKIPGLKIIYWLDSVRNAAISDSSSLPFIKIEPAQDLQIKCLHSTFVFDPVTDKEAELSLQLSCIDVEKLLLRAIACSRHTRLLDIQRELSKNVHICQSAADVILKREGDDSDPCSKKKDGGGPLVHEFCGDEVLQVRAYGSSYIKLRINIRNGRYLLYCSKNILATSALLECEEALNLGTVTATEVFISLRSKSILHLFASIGRSLGLKVYENCLASLKIPKSILHGSDLLLMGFPQSGNSYFLLMQLDKDFRPLFNLLETQPDTGGKSQSVSNINHVIRFNKIDIGQMQMVDDDLNLSLLNWEKISTLPNLATLNQLSKNALPELGLEHALQLPDCSQSSFSSIVDEVFESEKDVLGNHLSNQSFSSSYGVPSFSHLNSLSTFGQGTMVGVGTPKLDGGIQNSQSNTFNKVSSGLNGSFYLSGNAKGQLNSNSSAMFTSSMRNPPFQKLPSSKSEQDLSSLKSLYSTELSQFNALDEDQTKLINSSGSSLVANRAGTTVSRVSVPVSRMNGSKGSSYSHLVGHLGSTGSSSLTAAPSCQASESGASHAIGLRAISKPERTPHKRSLSEILTMIPSFKELEQDDRPWKRMRTLESTDSLGLSAFPSCRSGEHMYGSLLAEAIHGNAPSNIYVSVLLHVIRHCSLCIKHARLTSQMEALDIPYVEEVGLRASSLNLWFRLPLAQDGSWQHICLRLGKPGSMYWDVKIKDQHFQELWELCKGNNSTTWYPGVRIANASDVDSHIHYDPEGVVLGYKTVEADSIERLVSDLRRLSNARLFARGMRRLIGARADDKLDDLTASSDNNLQIQKAANEPVDKLTEQMRRIFKIEAVGLMSLWFSYGSVPFMAHFVVEWEAGREGCTMHVSPDHLWPHTKFLEDFINGGDVASFLDCIRLTAGPLLALAAAIPPARMSGPVSTGPSPISKQGSYLPSQGFLPNSSISNVVMPLSPAASTGTSVAPPLSSHNIHNAATLSAAGRCVSGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFSVDMRCFAGDQVWLQPATPPKGGPASGGSLPCPQFRPFIMEHVAQGLNALEPNFPAVTHTGGHLSLSNSLQSSAAQPLSANGNRSSPVTGVGMPRPVTIIGNQMSGNLSRVSNSMLPTSGMPSGISGVPMRIAQGTGVPVHVRGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPNLLKEILGSILKDNEGALLNLEQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQTQTSAQEEFSASETNEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVHGGEIASAQRARIELCLENHLGSSFNESSENSSVSKSNIHHDRAHSAVDFALTFVLDPVHIPYVNAAGGAAWLPYCVSVRLKYSFGENPHISFLRMDGSHGGRACWSRVDDWEKCKQKLAKAVDYANGNSLGDISQGRLRLVAESLQRTLQASLQQLRDGSVSSGSSLT
Length1811
PositionTail
OrganismDendrobium catenatum
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Epidendroideae> Malaxideae> Dendrobiinae> Dendrobium.
Aromaticity0.07
Grand average of hydropathy-0.134
Instability index47.74
Isoelectric point7.72
Molecular weight198564.51
Publications
PubMed=26754549
PubMed=28902843

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17004
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     350.88|      93|     138|     684|     784|       1
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  622-  689 (80.57/36.03)	.STL.PNLATLNQlskNALPELG...LEHALQlpdCS.QS.SF...SSIVDEVFESEKDVLGNHLSNQS..FSSS...........................................................................YGvPS
  690-  832 (127.28/67.81)	FSHL.NSLSTFGQ...GTMVGVGTPKLDGGIQ...NS.QSNTFNKVSSGLNGSFYLSGNAKGQLNSNSSAMFTSSmRNPPFQKLpssksEQD...LSSLKSLYSTElsqfnaldedqtklinssgsslvanragttvsrvsvpvsrmngsKG.SS
  833-  912 (109.93/47.17)	YSHLvGHLGSTGS...SSL..TAAP....SCQ...AS.ESGASHAI..GLRA...ISKPERTPHKRSLSEILT...MIPSFKEL.....EQDdrpWKRMRTLESTD.................................................
 1767- 1807 (33.10/ 8.19)	YANG.NSLGDISQ...GRLRLV.AESLQRTLQ...ASlQQLRDGSVSSG..........................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     354.71|     113|     181|    1170|    1312|       2
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 1179- 1309 (173.52/131.40)	SPdhLW....PHTKFLEDfinggdvasfLDCIrltAGPLLALAAAIPPArmSGPVSTGPSPISKQGSYLP...SQG...FLPN.SSISNVVMPLSPAASTGTSVAPPLSShNIHNAATLSAAG.................RCVSGIVPSSLLPIDVSVV
 1312- 1452 (181.19/83.16)	GP..YWiriiYRKRFSVD..........MRCF...AGDQVWLQPATPPK..GGPASGGSLPCPQFRPFIMehvAQGlnaLEPNfPAVTHTGGHLSLSNSLQSSAAQPLSA.NGNRSSPVTGVGmprpvtiignqmsgnlsRVSNSMLPTSGMPSGISGV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     274.84|      91|     117|     259|     355|       3
---------------------------------------------------------------------------
  259-  355 (133.38/93.54)	CVSlVMDTVLRQVKILRQGRWKDaIRFELiSDGIsgHGVNTSATQMAQDAELDS...TTQKIPGLKII..YWLDSVRNAAISDSSSLPF.IKIEPAQDLqIKC
  378-  474 (141.45/78.63)	CID.VEKLLLRAIACSRHTRLLD.IQREL.SKNV..HICQSAADVILKREGDDSdpcSKKKDGGGPLVheFCGDEVLQVRAYGSSYIKLrINIRNGRYL.LYC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.35|      48|     543|      21|      69|       4
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   21-   69 (75.59/62.80)	EESYLSLKELVETHKSPQERSDSEKKID.LLKF..IVKTRQRM....LRLHVLSkW
  564-  618 (68.76/51.53)	DKDFRPLFNLLETQPDTGGKSQSVSNINhVIRFnkIDIGQMQMvdddLNLSLLN.W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     282.13|      96|     727|     926|    1034|       6
---------------------------------------------------------------------------
  926- 1034 (153.91/122.29)	EhmyGSLLAEAIHGNaPSNI...YVSVLLHVIRHcsLC.....IKHAR.........................................LTSQMEALDIPYVEEVGLRASSLNLWFRLPLAQD.GSWQHIC.LRL.G.KPGSMYWDvKIKDqhfqelWELCK
 1049- 1152 (46.26/19.72)	N...ASDVDSHIHYD.PEGVvlgYKTVEADSIER..LVsdlrrLSNARlfargmrrligaraddklddltassdnnlqiqkaanepvdkLTEQMR..RIFKIEAVGL....MSLWF..............................................
 1694- 1758 (81.96/42.52)	.........................................................................................LTFVLDPVHIPYVNAAG.GAAWLPYCVSVRLKYSfGENPHISfLRMdGsHGGRACWS.RVDD......WEKCK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.63|      15|      22|    1487|    1507|       7
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 1487- 1502 (21.90/28.52)	WVpLAAL....KKVLRGILK
 1508- 1526 (21.73/ 6.48)	WL.FAQLpnllKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.76|      20|      27|     493|     518|       8
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  493-  512 (33.49/28.03)	LGTVTATEVFISLR.SKSILH
  521-  541 (31.27/12.39)	LGLKVYENCLASLKiPKSILH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17004 with Med14 domain of Kingdom Viridiplantae
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