<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17000
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLQGHAQAIVPSPARLGLSKATSPSLPSQAPNPNPNPNPNLKPTPFSASSTSAPVTTSSSLLSLLPPLPRAQSLLLQMALLSGKLFEVSPHRALWASARAGGPPTFLPGAQSQPLSLDPRHPSPPTTTKEVLSLFTSFQTQLFESVAELQEILDLQESKLKIAREIRNKDSTLLAFTRKLHEAEQVLDHLLDDYSDYRRDPKRLKGEPGEADYQSSLHSSLDLNEVLAYAHRISYTTFAPPEHGAGMAPLRGALPPAPQDNEMRASQLYHFADLDVGVPKKAPEGKEGAAEKITESLIEPTPPREEAPLHIPPPMLPITVPPGWKKGMPVELPLELPLVPPGWKPGDPVPLPPLEGVVVVNKGDEQRVGGVPLLSGLLLPQPKAPEPIQVKYVQLDINPDQDEYSSDYSSEVGSSEEDDEE |
Length | 421 |
Position | Middle |
Organism | Dendrobium catenatum |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae>
Epidendroideae> Malaxideae> Dendrobiinae> Dendrobium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.434 |
Instability index | 62.15 |
Isoelectric point | 5.08 |
Molecular weight | 45563.12 |
Publications | PubMed=26754549
PubMed=28902843
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP17000
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 84.44| 16| 18| 320| 335| 1
---------------------------------------------------------------------------
240- 251 (19.05/ 6.09) .PPEHGAGMA....PLR
320- 335 (34.57/17.36) VPPGWKKGMPVEL.PLE
339- 355 (30.82/14.64) VPPGWKPGDPVPLpPLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 140.60| 31| 32| 11| 41| 2
---------------------------------------------------------------------------
11- 41 (57.45/24.35) PSPARLGLSKA...TSPSLPSQAPNPNPNPNPNL
43- 75 (43.87/16.87) PTPFSASSTSApvtTSSSLLSLLP.PLPRAQSLL
90- 114 (39.28/14.34) PHRALWASARA...GGP..PTFLPGAQSQP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 133.78| 41| 79| 276| 318| 3
---------------------------------------------------------------------------
276- 318 (64.44/38.35) VGVPKKAPEGKEGAAEKITeSLIEPTPPREEaPLHIPPPMLPI
357- 397 (69.34/34.10) VVVVNKGDEQRVGGVPLLS.GLLLPQPKAPE.PIQVKYVQLDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 93.86| 22| 35| 133| 154| 4
---------------------------------------------------------------------------
133- 154 (34.32/26.40) SLFTSFQTQLFESVAELQEILD
171- 192 (33.03/25.11) STLLAFTRKLHEAEQVLDHLLD
208- 227 (26.52/18.61) PGEADYQSSLHSSL.DLNEVL.
---------------------------------------------------------------------------
|