<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16990

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYTTTSGGSGVSNSSVGGVSTRENARVDSSFSTSNYSQNSRKETDDKKISRKKSKRPLPLHPYKLKVDREPLNFRLGPPDLYPQTPNCPEETLTKEYLQSGYKETVDGIEEAREIVLTQASYFTKPEIILKCKEAIRRRLRAINESRAQKRKAGQVYGVPLTGHLLIKSGSFPEQKPSSEDFRKKWIEALSLHTKRLRSLADHVPHGYRRKSLFDVLIRHNVPLLRATWFIKVTYLNQIRPASTSISSGAQDKAHLSRTELWTKDVVEYLQQLLDEYLSKEGSVAPASSRDQSSPSLLSGSAQKVDSGGAASDVEEPSFSSKWWYMVHLLHWNYSEGLILSSVVVEWVLNQLQEKDSADAYELLLPIVYEIIDIIALSQTYTRGLVDIALRSINDLSLGGSNLVESTRKSSISSAFVEILRYLILAVPDSFVALDCFPLPACVVPDIYSAHRALKVTKDIDCLQTGKRDAHLRCMSFGYAVLSIQKRASNLANTANPGFQGQGAGKIVQLLDKAFILGDARLAYGALFEDFSDSPIEEKWMAEVSPSLRSSLKWIGSVDLSFICSVFFICEWATCGYRNYRTSTLENHKFTGVKDFSRVYAAVFLLKHKMEQVCVSSQSRNANLLGSTGKAVSLPENLPSMVSFENSFLDNKNMDHGKNGVDIFQSPGPLHDIIVCWLDQHEIGKGGGFKHLQVLILEFIRNGIFYPPAYVRHLIVSGIMDRNETSFDLERRKRHNRILKQLPGACLFEVLEESKVIEIAFLNAAVQVYSNERQLVLHGSFGHSSRLVNKHESYAPFYLRKHKDLSFASKEGSSTMLLESSRNSNIALHSRPSINSKVKDQIAELKVLISTLLRFPYSCSSQIETQVDESPGSLKRLLGSSGIRFDSPEGIPTCEDCREAKRQKVTDERSSSHQAIASNQSDDEDTWWVRKGPKSVESMKVEPANKLTKHISRGRQKTVRKMQSLAQLAAARIESSQGASTSHVCDNKMSCPHHRSVIDGKVPKDAVRLKTVHLSDIGKTIKQLRLLEKRSISIWLSTSIRQLVDGSEKTVSKPSNGNGSFSTALEDRNAVRWKLGEEELSTILFILDISSDLILAVRLLIWLLTKSLCGQNNNGHVGRNIMMLNKSRENHVCQVGEAFLLSALQRYENVIVATDMLPELLNEAMHRAMATLTPSGRASCSAAFVYSRNLLKKYRDVSSVIRWEKNFKSTCDQRFLAELDTGRMLDGDLGFSAGVPGGISDFDEYIRQKITVRVSRTGSSMKDIVQRHVEEAMHYFYGKERKPFATVNANSKNFTEKWDDAYQVAHEIVTGLIDCIRQNGGATFEGDPSILASAVSSIVGNVGPSVVKVPDFMNCNYQNLSSSSTSFNCVRYILYIHIISLCLLKEALGERFSRIFEVALAAEASAAISGSLSSVKSHRNPYQQSSEAHDISPNHSNEILNNSANVVGLRVAKATAAISALILGVIVHGAANLERMVTVFKLKEGLDVLQFIRSARSSSNGMSRSFGNFKLEPSVEVLAHWFRLLVGNAGTVCDGLVLEILGESYIIALSRMQRMLPLNLVLPPVYSIFAMVIWRPYILNSNIATREEIHLYNNLSWTINEVIRHQPFRDLCFQNTHAFYDILATDIGDSEFAAMLELHNPDKQLKTRAFVPLRARLLLNALIDCKMPPNSFIQEDGSLISESNEPMTFSEMEQNLLNQLVHVLDTLQPAKFHWQWVELRLLLNEKALLEKIDMKDMSLVEAIRSLSPNADNFAVSESDKFLSEIILTRILVRPDAAPLYAEIVHLLGRSLEESLVMDIKWILAGSDVLLGRKSIRQQLVSVAQRNGLSIKTLSWRPWGWSNIMADVTSNKGDKNKLDMVTIEEGEVVDDSSDGKRSSKMNFSTIDADIITSSQHFLIEKAIAELILPCIDRSSTDLCNSFAVELIKQMNMIDQQINMFTRGVNKQAGVGPPGVDVSSNKGSSRKSMRGGSPGLGRRAITVADSSPPSAAALKASIWLRMQFLVRLLPIVFADRNMRQMLASITLHLVGTRFVHEDADLSVPMVHMALPKREMESIEASAAALLDYSGDSLFDTFLCVLHGLLSSCKPSWLKPKSASKSLVKSPKDFSAFDREATEAMQADLDRMELPTTIRRRLQAAMPILPASLSMSLPYHPPLMSTTALSSLPPLTSISSPFQRSSTPAPARPLMKNKTLPSQDLDNEIDPWTLLEDGTSCSATSSAGGSAGSISGDHSNLKACSWLKGAVRMRRTDLTYVGVLDDES
Length2263
PositionKinase
OrganismDendrobium catenatum
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Epidendroideae> Malaxideae> Dendrobiinae> Dendrobium.
Aromaticity0.07
Grand average of hydropathy-0.204
Instability index49.30
Isoelectric point8.62
Molecular weight251706.11
Publications
PubMed=26754549
PubMed=28902843

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16990
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.47|      16|      22|    2140|    2155|       1
---------------------------------------------------------------------------
 2140- 2155 (30.16/16.75)	AMPILPASLSMSLPYH
 2163- 2178 (28.31/15.23)	ALSSLPPLTSISSPFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     430.65|     142|     193|    1677|    1824|       2
---------------------------------------------------------------------------
 1677- 1824 (222.03/141.19)	EDGSLISESNE.....PMTFSEMEQNLLNQLVHVLDTLQPAKFHWQWVELRL..LLNEKA..LLEKIDMKDMSLVEAIRSLSPNA....DNFAVSeSDKFLSeiiltRILVRPDAAPLYAEIVHLLGRS......LEESLVMDIKWILAGSDVLLGRKSIRQQLVSV
 1865- 2025 (208.62/120.59)	EEGEVVDDSSDgkrssKMNFSTIDADIITSSQHFLIEKAIAELILPCIDRSStdLCNSFAveLIKQMNMIDQQINMFTRGVNKQAgvgpPGVDVS.SNKGSS.....RKSMRGGSPGLGRRAITVADSSppsaaaLKASIWLRMQFLVRLLPIVFADRNMRQMLASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.40|      23|      28|     835|     857|       3
---------------------------------------------------------------------------
  835-  857 (37.47/26.88)	SINSKVKDQIAE....LKVLI.STLLRF
  860-  887 (29.94/19.73)	SCSSQIETQVDEspgsLKRLLgSSGIRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.56|      21|      28|    1475|    1495|       4
---------------------------------------------------------------------------
 1475- 1495 (34.84/25.52)	LERMVTVFKLKEGLDVL.QFIR
 1504- 1525 (34.73/25.41)	MSRSFGNFKLEPSVEVLaHWFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.91|      25|     130|      53|      77|       5
---------------------------------------------------------------------------
   53-   77 (46.12/31.32)	RKKSKRPLPLHPYKLK..VDREPLNFR
  185-  211 (41.79/27.62)	RKKWIEALSLHTKRLRslADHVPHGYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.46|      24|     191|     602|     627|       7
---------------------------------------------------------------------------
  602-  627 (35.97/25.22)	YAAVFLLKHKmeQVCVSSQSRNANLL
  796-  819 (42.50/23.66)	YAPFYLRKHK..DLSFASKEGSSTML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.06|      38|     131|     513|     570|       9
---------------------------------------------------------------------------
  513-  557 (55.78/52.05)	LDkafilGDARLAYG..ALFEDFsDSPIEEKWMAEVSPSlRSSLKWI
 1227- 1266 (63.27/22.97)	LD.....GDLGFSAGvpGGISDF.DEYIRQKITVRVSRT.GSSMKDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16990 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CEDCREAKRQKVTDERSSSHQAIASNQSDDE
2) MQRYTTTSGGSGVSNSSVGGVSTRENARVDSSFSTSNYSQNSRKETDDKKISRKKSKRPLPLHPYK
3) SMKVEPANKLTKHISRGRQKTVRKMQSLAQLAAARI
896
1
940
926
66
975










Molecular Recognition Features






MoRF SequenceStartStop




1) HPYKLKVD
63
70