<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16986

Description Mediator of RNA polymerase II transcription subunit 33A
SequenceMRTAPAEIMRDEMAVQWSGVMEYTKAAQEKGTDAVDWAVQLSAALASAGVASPSPELAQVLVSYLCWANDVPLAWKYIEKALSAGLVPPMVLLAFLSSRVIPTRHSRPAAYRLYLEILWRHAFSYASQVRVSNFKKIMLSIEDSLHLSEKFGVQASEPGLLVIEFIFYIVLQLLDATLDDEGLLELTPEKKFRWPIRAEDMDIDGEPYCQRNGYGEKLQKINSMKATELIIQFFQHKEISKLLSLARENMPTHWGSFSQRLHLLSTNSSTLQNSSVLRETLQQLLLDGFGRSCKSGRHVEFCAVIAPGCMASPGGHCHGATRSSLWIPIDLYLEDCIDGSVAATNAIEILSGLVKTLKAVNGTTWHDTFLGLWMASLRLVQREREPHEGPVPRLDPRLCILLSITTLAIADIIKEEEAEIVDEVEHSNQWKSKAVGGKCRQDLVSCLQILGDYESLLAPPPLFISAANQAAAKAMMFLSGLPIGSGYLECPNINDNAINLSGNLWHLIIESCISRKLVDTSAYFWPGYVSGKMKPMPHSLPGQVPGWSTLMKGAPLTPSLVNSLARSPASSLAELEKIFEVAINGSDDDKVSAAFIICSASLIRGWGIQEHTVRFVVKLLSPPVPVDYSGTDSHLICHGLMMNVVLTGISSVDCVQIFSFHGLVPELAGALMAICEVFGACVPNITWTTSGEEITAHSVFSNAFILLLRLWKFNHPPLEYCIMGDGAPVGSQLTPEYLLLLRNASLLSSCNSTKKRDGNSLLSTTCSSLPQPIFVDSFPKLKVWYRQHQACLASTLSGLVHGTPVHQNVDGLLNMMFRKINKGNNQSVGPGTSGSSLSNSSGPGSEDYHVKPMLPAWDIMEAVPFVVDAALSACSHGRLFPRELATGLKDLADFLPASLATIVSYFSAEVTRGVWKPAFMNGTDWPSPAANLSTVEEHIKKIVAATGVDVPSLVAGGISQATLPLPLAAFVSLTITYKLDKASERFLNLAGPALENLAASCPWPSMPIVAALWTQKVKRWSDFLVFSASRTVFHHNNDAIVQLLRSCFTATLGLSGDHMSSNGSVGRLLGHGFGSHFCGGLSPVAPGILYLRVYRCIKDIVLLTEDILSIMMQSVKEIADTVVSKEKIEKLKKTKHGQRYGQVSLATAMTRVKVAANLGATFVWLSGGSGLIQGLFQEMLPSWFLSAHELDKEGSSGGLVYILGGHALAYFTLLCGMFAWGIDTTSPSKRRPRVVEAHMEFLASALDGKISLGCDLALWRAYVSGFLGLVVECAASWVMEVNLGVVKRLSRGLRKWNQDDLALALLRKRGVEAMGAAAEVILACQW
Length1326
PositionTail
OrganismDendrobium catenatum
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Epidendroideae> Malaxideae> Dendrobiinae> Dendrobium.
Aromaticity0.08
Grand average of hydropathy0.160
Instability index40.56
Isoelectric point6.60
Molecular weight144407.58
Publications
PubMed=26754549
PubMed=28902843

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16986
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.47|      26|      37|     961|     987|       1
---------------------------------------------------------------------------
  961-  987 (38.73/22.40)	ATLPLPLAAFVSLTITYKLDKASErFL
  999- 1024 (51.74/26.71)	ASCPWPSMPIVAALWTQKVKRWSD.FL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.59|      33|      38|      44|      81|       2
---------------------------------------------------------------------------
   47-   79 (59.56/36.73)	SAGVASPSPELAQVLVSYLCWANDVPLAWK.YIE
   83-  116 (53.04/21.00)	SAGLVPPMVLLAFLSSRVIPTRHSRPAAYRlYLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     480.22|      98|     316|     455|     556|       4
---------------------------------------------------------------------------
  455-  556 (162.48/128.75)	SLLAPPPLFISA.......ANQAAAKAMMFLSGLPIGSGYLE..........CPNInDNAINL......SGNLW...HLIIESCISRKLVDTSAyfwPGYVSGKMKPMPHSLPGQVPGWS.TLMK.....GAPL
  577-  680 (110.42/74.06)	KIF.EVAINGSD.......DDKVSAAFIICSASLIRGWGIQEhtvrfvvkllSPPV...PVDY......SGTDS...HLICHG.LMMNVVLTG.......ISSVDCVQIFSFHGLVPELAgALMAicevfGA..
  682-  746 (84.00/54.08)	...VPNITWTTS.......GEEITAHS.VF...........................SNAFIL......LLRLWkfnHPPLEYCIM................GDGAPVGSQL...TPEYL.LLLR.....NASL
  768-  865 (123.32/83.81)	SL..PQPIFVDSfpklkvwYRQHQACLASTLSGLVHGTPVHQ............NV.DGLLNMmfrkinKGN.N...QSVGPGTSGSSLSNSSG...PGSEDYHVKPM.......LPAWD..IME.....AVPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.01|      62|     155|    1096|    1160|       7
---------------------------------------------------------------------------
 1096- 1160 (91.52/59.57)	CikDIVLLTEDIlSIMMQSVKEIADTVVSKEKIEKLKKTKHGQR.YGQVSLATAMTRVKVAANLGA
 1254- 1316 (102.49/57.72)	C..DLALWRAYV.SGFLGLVVECAASWVMEVNLGVVKRLSRGLRkWNQDDLALALLRKRGVEAMGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.49|      24|      34|     896|     919|      13
---------------------------------------------------------------------------
  896-  919 (42.36/28.51)	P.ASLATIVSYFSAEV.TRGVWKPAF
  928-  953 (31.13/18.99)	PaANLSTVEEHIKKIVaATGVDVPSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16986 with Med33 domain of Kingdom Viridiplantae
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