Description | Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MADRLTQLQDCLDDLLNQMYASLHYIHNRHPYGAIEGQPQGPDFRLAGDDDDKEDKKDKKKGSTADNANGDSDAKPDVATPAQEDPDKFNTGLRELAQDLVLKEQQIEYIVNSLPGLGNSERNQERRMKELERELREVEIEREKKEVDKRELIEVLVAETCTMTGRSKTWSEQQQQSPTFVNSSGRLYPVVHPKTSRLEKELVILEPKERLAKETPVPTSRTSNPAIDSTLSTSHPTSLPATVPAIDKQEQRSGTRNHSSNMDMAPDYFAYVDPQIESSKTAAARSHCQIHLSEVGPQHDSCPINGDAAYSKRADSKLGEDVRLSTHEFPLLSTLPTKLHLDLDHVSLYSDQSFDLGYKSRLAPPRVHRMHTRAWNTQHTRPLKDMLIEILEVRYPKRREELVTERTMLLGPTTRVTGFKGKRSLVSWFPCVASMARA |
Length | 438 |
Position | Middle |
Organism | Cercospora zeina |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.821 |
Instability index | 54.79 |
Isoelectric point | 6.14 |
Molecular weight | 49570.07 |
Publications | PubMed=29242781 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP16950 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.52| 14| 16| 125| 138| 1 --------------------------------------------------------------------------- 125- 138 (24.84/14.99) ERRMKELE.RELREV 141- 155 (19.68/10.58) EREKKEVDkRELIEV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 50.42| 14| 16| 215| 228| 2 --------------------------------------------------------------------------- 215- 228 (27.35/18.05) TPVPTSRTSN.PAID 233- 247 (23.07/14.05) TSHPTSLPATvPAID --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DYFAY 2) GPDFRLAGDDDDKEDKKDKKKGSTAD | 267 41 | 271 66 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab