<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16947

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMPRYLEMEPPKSVAAQTWHTLFKKAILRRYRPEELAKAFQQLQARHRTRPGDIATTLLGFRAAGPGVDDVLVFKYAEYLLKNGYFTASDLLSALLKSSSYIISKTAPNTRTSMPTCEERVVMIVTQFHITSDLPSSAGALQDLVFIIYRWLKVVGEDVVGKQLSGLQAMDATLNGIYESLAQLALATLGSKGMRKLTQYRWWKQRRSTVVNEMQNYDVNVLQWMNSQLAGRLRTLISMPPYLEIDADGKPQFSDEQILAQVEELPVVQSRAGIFVWLNAALAARPLTDDTTILTYIQGRSSDNPQSLVVDLLVAAFDVLTNFMLTKEPRQNAKVVRSFICNKLPALIAILANNMQPAISADACIQMALMPGGMISMDPLPPISAGATDVRDSLKTTRLEFLQACVLHGLVNEQTVALILQESVALPRVAKLNKDSLVPQCANNVSKLAEHIEELAGMQGNVGAIAGCVVETVNNMCMSKDTMSLKSVCDKLIRRIPYMDFVMQYTQPGMLLLPLCNLLNDWTHDQDQSEFTPAYEEFASILLFTLAVIYRYDLSFADIGILGDSFVARLLEEMTVSKPPSELPAEQASQLTQWIEGLFAVDEHGDTSGIGDDVMRQCSPQSFYTLVPTLFEQSILACRSQTLSMNTFKSGLELLLEPFLLPSLVMGLGWLAKHSWEDHSDADVLIQVLEKLLKPSSNAPETQAMHRAVLAMVATPLHNSLEEYSRKHPNKKGTELLDLLKPHLNQQRSLRSRQNELDQWLQDQKGLQGRVQQVIGELISWSSTSTNPPNPPPQYTHRTFAIACQLLDSQTLLDAIVAEVHKTVYNNVPIALDVCTSLICAPAPVPMGAQQASHWTSPTGKLRAHVRIASSDAQALLGLAKSQAEILVRLGRRVQAQMSFAAQMPAISMPMPMQDQTTDQMMQDLGLALDNNANASNVDAAMATNASAMASNTEMSGMDQSIDLTNLNNASADELAKLTVDGDAMNLDQNNQFLADFGMGVGDAQANAQNSGMANPDDDIFAGLNMDMGELDDFTFD
Length1036
PositionTail
OrganismCercospora zeina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.06
Grand average of hydropathy-0.079
Instability index46.52
Isoelectric point5.04
Molecular weight114091.59
Publications
PubMed=29242781

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16947
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.85|      35|     518|     280|     355|       1
---------------------------------------------------------------------------
   49-   86 (57.90/23.57)	RPGDIATTLLGF...RAAG.PG..VDDVLVfkyAEY.LLKNGYFT
  284-  325 (42.96/88.94)	RPLTDDTTILTYiqgRSSDnPQslVVDLLV...AAFdVLTNFMLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.01|      14|      30|     649|     662|       4
---------------------------------------------------------------------------
  649-  662 (24.70/15.80)	SGLELL...LEPFLLPS
  679-  695 (18.31/ 9.71)	SDADVLiqvLEKLLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.34|      43|      50|     517|     566|       6
---------------------------------------------------------------------------
  517-  563 (63.09/80.25)	LLNDWTHDQDQSEFtPAyeEFASILLFTLAVIYRYDlSFADIGILGD
  569-  611 (76.25/61.58)	LLEEMTVSKPPSEL.PA..EQASQLTQWIEGLFAVD.EHGDTSGIGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.32|      27|     135|     227|     254|       7
---------------------------------------------------------------------------
  227-  254 (44.60/32.96)	QLAGRLRTLISMPPYLEIDAdGKPQFSD
  365-  391 (50.72/32.73)	QMALMPGGMISMDPLPPISA.GATDVRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.02|      16|      26|     987|    1002|       9
---------------------------------------------------------------------------
  987- 1002 (29.70/16.29)	DQN.......NQFLADFGMGVGD
 1007- 1029 (22.32/10.62)	AQNsgmanpdDDIFAGLNMDMGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.65|      15|      29|     475|     489|      10
---------------------------------------------------------------------------
  475-  489 (27.88/18.52)	MCMSKDTMSLKSVCD
  502-  516 (28.77/19.37)	MQYTQPGMLLLPLCN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16947 with Med5 domain of Kingdom Fungi
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