<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16940

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMDYGHRSRGGGTGQRPLPPQRAVSGSHALQQGLKRPAVPSRLNHVRSVSQPGFYVDLTSDATTRHNTAALTNNAAALHASPTFIDLSDDDHERPAKRARTDAPEASVLDPARQRLPGSPLPPPPLPRLPACMGRSRRPVVDRLARRANGLEAPACATRLPLPKQVADFAPWNGQHPEDVVTDGVVKGGYYDKPPGPNSTESNSARPTIWPNLSAKNNMGLQTLSYLFTSVLEKRQALGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPEVPLRKQSRTIPHGIRGKLLMEQCLGKNIAMPRAVWLAKCVGANELRAFRRKGVSGTAAAAGESKWVREWTVQVEHFLESVIAMCGQPEWQSKMDYAVKLATAFYTERLLETDHYLEWIVTSYAQAMLDRVPIWIVLVQLYWKEITTFGRRGRQLADATLENLQQLTKLDSRAHDSLKARLQKLVMIMAVTNRGCLIIPRSWQKYQHLLILKTTAPGSPAHNITKRNRRLLAPLMKTPQNTRCALLTLYGLLDAHALHVDVERLAAACQAIVPDADKLVAALLTWSSSVYRTGVNRVYLAAKVIADLSTKGLDTDSAILGYLQIPQAASIVAADVHRVLAELVRDNSFSCGRYLQWLITSGNLSGSASPNLATGLLIALPADAVPAHLKNTRNSLLHRISGVRDESAMVSAVLHVLMDDNGTASRVHAMLQTENLGAVAKQQLSEALIAQAEYLLKEGLLNHSWFCFARDVFEIILDMQALRLLLQMAMTSGDVGILASISDTIDFHRKSFAAMGHLTQMVDKLLEQYRILRSQQSLDRPLIISLMTLTRPWADKMHVLQSQHILAALPNDLLVCEQQTSMAACSPASDSLVSMQAGGLDSDQEIDAVFASGNTMDEQLMQRVFARISQRAGKLESEREHAPSRVCAWLAQLRAVDITTFDVLAKCHAQACLRSSGDAAAPLTLISALVASGCMEMETVVSLAQGMKTPASACAVLRLLTTTASICIGLDEHEAYRFRVIQQRVRQTSADTLLTLLITAMEDPKFPAHESGMAALLLDYTVSKYQSCLRALNSARSSPAFLANCSALVTRILTPPAASYTSGFTLDAKTVTGIADAISVAQCTVALALLAKKETLRGAPNESTLQPAILEAIVTGSEIWPQLLESAGQDTVRSIYQWAKDQVLACTLPGNATCSVDEAQASRNLDILCVAHHSAKDNGRSHIISSILDRLKEILERLPKEPLGVEHKQHLMALRILLHLSILYACDTSSDRESPRTSRESLLATLCILLGHPGLQCHQEVVEYIHDVACALSDALPAESLTALGLAMLRNGVRDPRLAFVLGATNNPDAWLALVSYPQPQPGGGSAQAKALLQRAAQQQQQQQQQAQTAGRPGPMSSAGGSAVLQRAMSMRTGQQPQGEPKVVPYALRRWEIMSDATPSMGENDTSLSLGLFGARKAF
Length1447
PositionKinase
OrganismCercospora zeina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.05
Grand average of hydropathy-0.107
Instability index50.46
Isoelectric point8.88
Molecular weight157654.56
Publications
PubMed=29242781

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16940
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     360.05|     105|     121|      11|     127|       1
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   11-  121 (168.65/114.53)	GTGQRPLPPQRAVSGshalQQGLKRPAVPSRLNHVRSVSQ..P..GFY.VDLTSDATTR...HNTAALTNN..........AAALHASPTFIDLS....DDDHERPAkRARTDAPE...........ASVLDpARQRLPGSPLP
  133-  243 (128.23/80.99)	GRSRRPVVDRLARRA.....NGLEAPACATRLPLPKQVADfaPwnGQHpEDVVTDGVVKggyYDKPPGPNS..........TESNSARPTI.................WPNLSAKNnmglqtlsylfTSVLE.KRQALGKCTAP
  803-  876 (63.18/29.59)	...................QQSLDRPLIISLMTLTRPWAD..K..MHV...LQS....Q...HILAALPNDllvceqqtsmAACSPASDSLVSMQagglDSDQEIDA.....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.18|      14|      19|     374|     389|       2
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  374-  389 (22.23/18.01)	YTERLLetDHYLEWIV
  392-  405 (26.95/15.24)	YAQAML..DRVPIWIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.67|      13|      19|     281|     299|       3
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  281-  297 (19.87/22.52)	PHGIrgklLMEQCLGKN
  301-  313 (24.80/ 9.36)	PRAV....WLAKCVGAN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.58|      17|      21|     463|     482|       4
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  463-  482 (28.14/24.74)	GCliiPRS..WQKYQHLL..ILKT
  486-  506 (20.44/ 9.69)	GS...PAHniTKRNRRLLapLMKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.20|      39|     115|     581|     619|       6
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  581-  619 (62.77/38.92)	LDTDS....AIL.....GYLQIPQAASIVAADVHRVLAELVRDNSFSC
 1102- 1126 (26.60/12.11)	.....................IADAISVAQCTV..ALALLAKKETLRG
 1127- 1174 (53.84/32.30)	APNEStlqpAILeaivtGSEIWPQLLESAGQDTVRSIYQWAKDQVLAC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.22|      15|      20|     886|     900|       7
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  886-  900 (26.43/15.44)	EQLMQRVFARISQ.RA
  908-  923 (24.79/14.02)	EHAPSRVCAWLAQlRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.49|      59|     121|    1260|    1322|       8
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 1260- 1322 (93.38/68.68)	RESPRTS...RESLLATLCILLG.HPglQCHQEVVEYIHDVACALSDALPA..ESLTALGLAMLrnGVR
 1380- 1444 (92.11/55.93)	RPGPMSSaggSAVLQRAMSMRTGqQP..QGEPKVVPYALRRWEIMSDATPSmgENDTSLSLGLF..GAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.48|      52|     509|     648|     712|       9
---------------------------------------------------------------------------
  648-  712 (76.28/77.33)	LPADAVPA..HLKNTRNsllHRISGVRDESAmvsavlhvlmDDNGTASRVHAML..........QTENLGAVAKQQL
 1176- 1239 (80.20/53.12)	LPGNATCSvdEAQASRN...LDILCVAHHSA..........KDNGRSHIISSILdrlkeilerlPKEPLGVEHKQHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.71|      48|     509|     523|     573|      10
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  523-  573 (75.45/52.37)	AH.....ALHVD..VERL.........AAACQAIVPDADKLVAALLTWSSSVYRTGVNrvyLAAKVI
 1036- 1099 (63.25/36.21)	AHesgmaALLLDytVSKYqsclralnsARSSPAFLANCSALVTRILTPPAASYTSGFT...LDAKTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.75|      18|      18|     415|     432|      13
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  415-  432 (29.45/18.68)	TTFGRRGRQLADATLENL
  436-  453 (28.30/17.63)	TKLDSRAHDSLKARLQKL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16940 with Med12 domain of Kingdom Fungi
Unable to open file!