<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16938

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDSLADSSRVDSVMRVFVRKMHRLGTPALAWPDPSSLIIPSRACRFRACSRATSTTALALAALSPTTAATPLIISALSRLRNREQVTGALYATAGDPGRVAEASGGDGRGVGGTRAHVGVSAGATAAGEEMPGRLMTNEQGAVGSQDLKKDRSQAQIGNLSQKRDLAQMQGAAHTNGNATGHPSAPLPNGLPAQKEPLPTTNGRSNGASAAISRLPTPPPLDQSWRTSDSNRPFGVLLARQAQLCFGELGATLDKMNDMPVPQPAATNGALTQTNDSSQESQARKRLLMTFAQDHRDRFIKALILSDWARNEKETAKLVDLKTWLLSQMTAQDNAMHFIGITKHDVARAKMPNPNIEGAMELLASGKAPSKWPDLGYIPPPKLTAKQLTNTLLDMNVALATRLNLHEDLPQYFRDFSIANGRATFRVPGEFEVDLSVADEDPSSQFYLIDLRFSFTPAPALTDDVLRNALEAQTNEALNSRGLLGCYEFLHNFVLTHKITVLKSQSVQLFREKWFNCLVTETQRRVLAIQYWKDQSGKKSWIEFGISTGKSKGKQPRRKATSQHSIRWFRQGQEVHDQAILVDWSDLDLDAILSQVTAKHASWSLCTIHDRLQALAGPRSKVLTQLSTSECSADDCNLTLSLSGLRSPIAIKIETVTGLATISPSSRDAATAQRHLNRDPSIDSSGSIAQLLCRGVQDKVRKMAVSARWQLLDPRCFGPQPNFRTWFGSDFVCYDVFACNEAWGERWLLCTTYSLTGQKWWVVQINQRVVEQGRSIMSVVDARPLDVTSSAPSRADLLRIKTMGEAEVSFAVLVAELGTNKIPYHLENLCSLTFDGDRSNESATTVVYIRMSPQDLKKAELATYKPLAMTEWIRIVYDASLDENEDSGESRHDIRLTLEPSKLKHLKEYLCTTQSRDGDVAMNASGGLALSLRAQFGQPYMKEIVRLLKRCRELDSALSAARRLQYTCTTVGLRKLAFTYGTSQQYNGVLASKGASTTLRLGPTSSNPHQRIRIHLEEVYNRAADNPFFSLTFAMSATQPFLEEVSKLEAKHTAQRSLTLHTHHVFSYSLVYHAPLAPCRFTIMLHWDHQPNTHNKTVSYTVTLWPKKGVELAGDLTQALIDLSKDAGSTAEGWLGNNKGGFTSNAKGLHAMLQRLDDFMLNTSNGQDDYVTNLDKQETPLPEAKPPLNRNSSKSQIPTQQKPPTPAQLKNQPRLSQNQMRPGQDSTARQMTVPAAHVQRPNQNNGGVKQEIIELD
Length1256
PositionTail
OrganismCercospora zeina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.06
Grand average of hydropathy-0.413
Instability index42.91
Isoelectric point9.06
Molecular weight138471.37
Publications
PubMed=29242781

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16938
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.21|      35|     141|     584|     619|       1
---------------------------------------------------------------------------
  324-  355 (43.66/25.85)	W.......LLSQMTAQDNAMHFIGItkHDVARAkMPNPN
  372-  400 (44.99/26.87)	WPDLGY.IPPPKLTAKQLTNTLL.....DMNVA.LA...
  584-  619 (58.55/42.35)	WSDLDLdAILSQVTAKHASWSLCTI..HDRLQA.LAGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     487.37|     165|     216|     648|     862|       2
---------------------------------------------------------------------------
  648-  832 (240.77/245.31)	PIAIKiETVTGLATISPSSRDAATAQRH...LNRDPSidSSGSIAQLLCrGVQDKVRKMAVSARWQL.LDPRC.FGpQPNFRtwfgsDFV.....CYDVFACNEAwgERWL..LCTTYSLTGQKWWVV...QINQRVVEQGRSimSVVDARPldvTSSAPS...RADLLRIKTMGEAEVSFAVLVAELGTNkiPYhLENLCSL
  866- 1048 (246.60/143.93)	PLAMT.EWIRIVYDASLDENEDSGESRHdirLTLEPS..KLKHLKEYLC.TTQSRDGDVAMNASGGLaLSLRAqFG.QPYMK.....EIVrllkrCRELDSALSA..ARRLqyTCTTVGLRKLAFTYGtsqQYNGVLASKGAS..TTLRLGP...TSSNPHqriRIHLEEVYNRAADNPFFSLTFAMSATQ..PF.LEEVSKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.42|      24|      29|     152|     177|       3
---------------------------------------------------------------------------
  152-  171 (27.95/12.69)	........RS.QAQIGN.L.SQKRDLAQMQG
  174-  203 (30.45/17.54)	HTNGnatgHP.SAPLPNgLpAQKEPLPTTNG
  204-  223 (24.01/ 6.57)	RSNG......aSAAISR.L.PTPPPLDQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.31|      27|      32|      83|     112|       4
---------------------------------------------------------------------------
   83-  112 (43.43/39.14)	REQVTGALYAT.AGD..PGRVAEASGGdgrGVG
  115-  144 (39.87/26.12)	RAHVGVSAGATaAGEemPGRLMTNEQG...AVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16938 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LDKMNDMPVPQPAATNGALTQTNDSSQESQARKRLL
2) SNGQDDYVTNLDKQETPLPEAKPPLNRNSSKSQIPTQQKPPTPAQLKNQPRLSQNQMRPGQDSTARQMTVPAAHVQRPNQNNGGVKQEIIELD
3) TGALYATAGDPGRVAEASGGDGRGVGGTRAHVGVSAGATAAGEEMPGRLMTNEQGAVGSQDLKKDRSQAQIGNLSQKRDLAQMQGAAHTNGNATGHPSAPLPNGLPAQKEPLPTTNGRSNGASAAISRLPTPPPLDQSWRTSDSNRP
253
1164
87
288
1256
233










Molecular Recognition Features






MoRF SequenceStartStop




NANANA