<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16918
Description |
Mediator of RNA polymerase II transcription subunit 8 (Fragment) |
Sequence | EKQLELTLEALISQVADLKNSLVSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLLRNQVIIPLVLSPDRDEEIMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDVAQKQIQSLNKMCSNLLEKISKEERESESGGLRQNKQTFNPADTNALVAAVAFGKGLSNRRPPGSGASVQSGQPGAGAIIAGASGMQQVSMSGAPAQQQPMLAGVQMAQTGQPGKMPSGIKTNIKSASMHPYQR |
Length | 264 |
Position | Head |
Organism | Columba livia (Rock dove) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda>
Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Columba.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.465 |
Instability index | 50.68 |
Isoelectric point | 7.18 |
Molecular weight | 28785.44 |
Publications | PubMed=23371554
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP16918
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 52.73| 10| 26| 195| 204| 1
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195- 204 (19.49/10.03) SGASV.QSGQP
222- 230 (18.21/ 8.95) SGAPA.QQ.QP
233- 243 (15.02/ 6.27) AGVQMaQTGQP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.44| 25| 27| 63| 88| 2
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63- 88 (38.07/32.77) KTPLLRNQViIPLVLSPDRDEEIMRQ
92- 116 (44.37/33.00) RVPVFSHEV.VPDHLRTKPDPEVEEQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.49| 17| 28| 6| 22| 3
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6- 22 (25.46/14.08) LTLEALISQVADLKNSL
36- 52 (29.03/16.81) LTWPSVLDSFALLSGQL
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|