<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16915

Description Mediator complex subunit 14
SequenceMQRGEDQRSDTASASSLFGAEAQAGSPYSEAEADVPAWSQQSTLLNTPFYVPQRLREKALVNLEDGNRQTCPHFYHQNPRTTVLLAPPFPSFHSDSKGARTEVLAANLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNTNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDPCSIEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRLELSNMDIPHQGVQVEGDGFSHSIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQQPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSSRPGECTIFAAVRDLMVNLTLPPGGRP
Length1494
PositionTail
OrganismColumba livia (Rock dove)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Columba.
Aromaticity0.07
Grand average of hydropathy-0.245
Instability index54.47
Isoelectric point8.77
Molecular weight166021.23
Publications
PubMed=23371554

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16915
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      97.52|      16|      32|    1096|    1111|       1
---------------------------------------------------------------------------
 1078- 1093 (21.47/ 8.56)	SMMHTQSPGNLHAASS
 1096- 1111 (29.74/15.34)	GALRAPSPASFGPTPS
 1130- 1144 (23.93/10.58)	GTIDPSSPYTM.MSPS
 1158- 1169 (22.38/ 9.31)	G....PSPAARMPGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.17|      23|     282|     920|     948|       2
---------------------------------------------------------------------------
  920-  948 (31.29/34.09)	KLP......TVPmlglTQRTNTAYQCFsILPqSPT
 1204- 1232 (35.88/18.72)	KLPqrswaaSIP....TILTHSALNIL.LLP.SPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.48|      11|      33|     243|     253|       3
---------------------------------------------------------------------------
  243-  253 (19.28/12.53)	DLPPQLANLTV
  278-  288 (20.20/13.59)	DIPWRLLKLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     339.37|     110|     509|     294|     418|       4
---------------------------------------------------------------------------
  294-  415 (173.48/156.82)	ETGDGRALVHSMQI.....................NFIHQLVQSRLFADEKPlqdmynCLHSFCLALQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASVHKVTIKIDETdvskpLQISHEPPLP
  430-  565 (165.89/112.21)	HLSIEKLLIDSVHArshqklqelkailksyntndnSFIETALPTLVIPILEP......CGRSECLHVFVD.LHSGmfQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLkfwLGQQRCKQSIKHLPTVSSET.....LQLANYASHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.77|      21|     509|     185|     216|       8
---------------------------------------------------------------------------
  163-  183 (32.64/29.02)	ILFVDTADRLASLARDALVHA
  196-  216 (38.14/14.26)	VLTTGSYPRLPTCIRDKIIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.71|      66|    1304|      24|      97|      16
---------------------------------------------------------------------------
   24-   97 (103.10/85.55)	AGSPYsEAEADVpAWSQqstLLNTPFYVpqrLREKA.LVNLE...DGNRQT..CPHFYHQNPRTTVLLAPP.FPSFHSDSK
 1331- 1403 (99.61/59.39)	AGPPF.KANTLI.AFTK...LLGAPTHI...LRDCVhIMKLElfpDQASQLkwNVQFCLTIPPSAPPIAPPgTPAVVLKSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16915 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQQPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWA
1006
1211










Molecular Recognition Features






MoRF SequenceStartStop




NANANA