<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16914

Description Mediator complex subunit 12 (Fragment)
SequenceQDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIEWTQIITKYLSEQLQKIAEFYRQLPGQGCGSPSGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSAQTGNPLPSTPAPQPAAGNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEETGLSEPMDIDHNSSMIFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKPLLKDKSVEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGSNVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTANNEMNSLLENIAKATIEVFQQSAETSSASSAGNGVNNISSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALETEKKAAEPAKADKTSSNPATATEERKKKQSKTKKRNQSSNKTEDFVLGPSRGVSYGVGMPTDLLHHQPGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPPGMGSMMGIDPSYKPTVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQPVRQMAPTPSYGTLQPSQGYTPYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQRFPHQSIQQAPMMSGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQQQMLRQQQQQQQQQQQQQQQPQPPPPPQPQPQQQPQVSTVPQPQAQGQPPGLGMQALPPQQPIFQRQGLQQTQQQQQTAALVRQLQQQLSNTQTQQNNNPFGRY
Length2089
PositionKinase
OrganismColumba livia (Rock dove)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Columba.
Aromaticity0.07
Grand average of hydropathy-0.478
Instability index55.19
Isoelectric point6.49
Molecular weight233266.37
Publications
PubMed=23371554

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16914
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.09|      12|      15|    1980|    1991|       1
---------------------------------------------------------------------------
 1977- 1987 (22.01/ 7.91)	YLR.QQQQQQQQ
 2009- 2020 (23.59/ 9.13)	PPPPQPQPQQQP
 2053- 2064 (20.49/ 6.72)	GLQQTQQQQQTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.40|      17|      20|    1861|    1879|       2
---------------------------------------------------------------------------
 1864- 1889 (20.89/ 9.58)	GYTPYvsHIGLQQHPSqsgtmvpPTY
 2031- 2047 (30.51/10.40)	QGQPP..GLGMQALPP.......QQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.64|      15|      19|    1782|    1799|       3
---------------------------------------------------------------------------
 1798- 1815 (11.28/12.61)	P.pGMgSMMGIDPSYkPTV
 1843- 1859 (21.36/ 6.19)	GqqPV.RQMAPTPSY.GTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1576|    1594|       4
---------------------------------------------------------------------------
 1576- 1594 (14.83/27.85)	TKgNKIAGFDsIFkkEGLQ
 1597- 1611 (30.03/22.19)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     155.27|      20|      20|    1723|    1742|       5
---------------------------------------------------------------------------
 1723- 1742 (34.86/16.08)	PS.RG...VS.......Y.GVGMPTD.LL.HHQ.P
 1744- 1764 (22.90/ 7.87)	ST.MS..rLA.......Y.GQS.PVG.LYaQNQ.P
 1770- 1791 (24.28/ 8.82)	PR.LD...TS.......YrPVRMPLGkLV.QSR.P
 1899- 1925 (23.31/ 8.16)	PS.SN...PAlvdpvrqM.QQR.PSG.YV.HQQaP
 1926- 1946 (26.29/10.20)	GYgHT...LG.......N.TQRFPHQ.SI.QQA.P
 1947- 1965 (23.64/ 8.38)	MM.SGmnhLG.........PQGVPSG.I....R.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.18|      20|      20|    1672|    1691|       6
---------------------------------------------------------------------------
 1672- 1691 (30.42/21.20)	ALETEKKAAEPAKADKTSSN
 1695- 1714 (30.76/21.54)	ATEERKKKQSKTKKRNQSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.20|      19|      19|    1138|    1156|       9
---------------------------------------------------------------------------
 1126- 1144 (27.83/19.51)	NVDGAVFAVLKAVFVLGDA
 1145- 1163 (35.37/27.26)	ELKGSGFSHPGGVDDLMDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     266.65|      90|     160|    1315|    1416|      11
---------------------------------------------------------------------------
 1315- 1416 (129.26/100.67)	NISSSASATPASNkSKPILSSLERSGVWLVAPLIAKLPTSVQGHVL..KAAGEELEKgqHLgsssRKE.RDRQK...QKSMSLLSQQPFLSLVLTClkgqdEQREGLL
 1479- 1574 (137.39/78.89)	DIISSGTVDMQSN.NELFTTVLDMLSVLINGTLAADMSSISQGSMEenKRAYMNLVK..KL....RKElGDRQSdslEKVRQLLPLPKQTRDVITC.....EPQGSLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.53|      13|      19|     934|     952|      13
---------------------------------------------------------------------------
  934-  949 (20.65/19.62)	NTIYcnvEPSDSNMLW
  956-  968 (24.87/ 7.03)	DTIE...NPSAHNFTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.54|      11|      21|    1007|    1017|      14
---------------------------------------------------------------------------
 1007- 1017 (20.72/10.72)	AILCAELTGYC
 1030- 1040 (21.82/11.68)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.30|      19|      23|     629|     650|      15
---------------------------------------------------------------------------
  629-  650 (30.70/28.85)	LSEPMdidHNSSMIFDDMEKTD
  654-  672 (38.59/26.17)	FSPPM...HCESKASPSPEKPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.48|      10|      23|     279|     288|      16
---------------------------------------------------------------------------
  279-  288 (20.46/ 8.86)	AGGHPPHILS
  305-  314 (23.02/11.11)	AGNPPPSPFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.59|      11|     108|     181|     191|      17
---------------------------------------------------------------------------
  181-  191 (25.24/12.50)	GCGSPSGPMPQ
  292-  302 (23.35/10.92)	GNPLPSTPAPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.10|      11|      19|    1225|    1240|      21
---------------------------------------------------------------------------
 1225- 1240 (10.71/20.68)	QRlmQLIcypHRLLDN
 1247- 1257 (20.39/ 9.94)	QR..QRI...KRILQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16914 with Med12 domain of Kingdom Metazoa
Unable to open file!