<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16902

Description Mediator complex subunit 1
SequenceMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNITADALDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPATTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYASQALTTLGVQVLGADGGENKFKGSNQSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNAGDLGKEKSQKRVKEGNGSGGNMAGPGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKMKSSKSEGSSGSKMSSSLYSGQGGSSSGQSKSSAQSVGKSGSSPITKHGLSSGSGSAKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPNTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGDFQGKREKSDKEKSKVSVSGGSGDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHGMKPESWSKSPISAEQPLSMASSAILAAERPARPSPEFLIGEEDDDLMDVALIGN
Length939
PositionMiddle
OrganismColumba livia (Rock dove)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Columba.
Aromaticity0.03
Grand average of hydropathy-0.966
Instability index61.38
Isoelectric point9.22
Molecular weight97402.40
Publications
PubMed=23371554

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16902
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     528.59|      61|      61|     433|     493|       1
---------------------------------------------------------------------------
  291-  347 (53.29/ 8.84)	.....AAS..K.AL.........GSSDIMEHH..SGGQSPLLNAGDLG.KEKSQKrvKE.GnGSG.GNMAG.....PGI............DGKPG
  348-  409 (56.30/ 9.90)	KRSRTPSS.dG.KSkeklpkrkkQETDGKS.PSHSSSNRPFTPPASTG....GSK..SP.G.SSGrSQTPP.......................GV
  433-  493 (107.12/27.87)	SHGQYTSS..G.SV.........TSSSSKSHHSHSSSSSSSSSSSTSG.KMKSSK..SE.G.SSG.SKMSS.....SLY............SGQGG
  495-  546 (65.73/13.24)	SSGQSKSS..AqSV.........GKSGSSPITKHG.LSSGSGSA.....KM...K..PQ.G.KPS.SLMNP.....SM..............SKPN
  550-  595 (64.73/12.88)	SHSR.PSG..G.SD.........KLASPMKPVPNTPPSS..........KAKSPI..SS.G.SGG.SHM......................SGTGS
  596-  677 (59.23/10.94)	SSSMKSSSgmG.SS.........GSMSQKPPPSSNSSTASSSSFSSSGsSMSSSQ..NQhG.SSK.GKSPSrnkkpSLTavidklkhgvvtSGPGG
  681-  729 (62.14/11.97)	MDGQ.........M.........GPSSNSSSHTMSSKHNMSGGDFQGK.REKSDK..EK.......SKVSV.....S..............GGSGD
  780-  841 (60.06/11.23)	QMASSKSY..G.SP.........LISGSTPKHERCSPSHSKSPAYTPQ.NI...D..SE.S.ESG.SSIAE.....KSY.......qnspsSDDG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     378.67|      93|     106|      86|     178|       2
---------------------------------------------------------------------------
   10-   81 (94.98/30.72)	....................PPQD......F.STLYGSSP.LER..QNSSSGSPRMEMGPGGN......KQKKKKSRMPA...DKPKHQT..EDDfqrelfSMDVDSQNPIFD
   86-  178 (159.90/56.21)	ADALDTPHITPAP..SQCSTPPTT......YPQPIPHSQPSIQRMVRLSSSDSIGADVTDILS......DIAEEASKLPATTEDCPPIGTPVRDS......SSSGHSQSALFD
  184-  285 (123.79/42.03)	TNNSENPYTDPADliADAAVSPNSdssnhfFPDGVDFN.PD...LLNSQSQSGFGEEYFDESSqsgdtdDFKGYASQ.ALTTLGVQVLGADGGEN......KFKGSNQSDTVD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16902 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADVTDILSDIAEEASKLPATTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPN
2) ALGSSDIMEHHSGGQSPLLNAGDLGKEKSQKRVKEGNGSGGNMAGPGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKMKSSKSEGSSGSKMSSSLYSGQGGSSSGQSKSSAQSVGKSGSSPITKHGLSSGSGSAKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPNTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGDFQGKREKSDKEKSKVSVSGGSGDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHGMKPESWSKSPISAEQPLSMASSAILAAERPARPSPEFLIGEEDDDL
3) IFDVNITADALDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSI
4) MLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDV
133
295
79
1
206
931
131
73










Molecular Recognition Features






MoRF SequenceStartStop




1) ASSAILAAER
2) FGEEYF
3) IKAKVTL
4) IPKITIQIPKGTV
5) IRPLPEYS
6) MLMNLLKENPPQDFSTLYGS
7) NKKPSLTAVIDKLKHGVV
8) SPEFLIGEEDDDLMDVALIGN
9) VAKIIISKH
10) YGSPLI
905
233
760
414
842
1
654
919
745
787
914
238
766
426
849
20
671
939
753
792