<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16816

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVEFSALVRRAAEDSYLSLKKLVEAYKAPEERSDSEKKIDLLKFIVKTRQRMLRLHVLSKWCLQVPLIQYCQQLAATLSSHDTCFTQTADSLFFMHEGLQQARAPIFDVPSSIEVLLTGGYSRLPKCIEDMGFQATLTDNQQKPALKKLEMVLRSKLLDVPIPKEISNVTVSDGTAVLCVDGEFKVYLTLGYRGYLHLWRILHLELLVGEKNEHVKLEETRRYALGDDLERRMAAAENPFMILYAFLHELCVSLVMDTVLRQVKILRLGRWKDAIRFELISDGITGQGVSSSVSQSAQDVELESSGQKVPGLKIVYWLDWEGNSAGPDSGVPPFIRIEQGQDLQIKCLHSTFVFDPITNKEAELSFDQSCIDVEKLLLRAIACNRHTRLLDIHRELSRNVQLCQVPGDVVLKHESAETNSCLRKFRFQEIASFPGSGGGVVESVGWLGFRDEGRLHASVGEEVLQVRAYGTSYITLRINIRNGRFLLQCSQNILAPSALLECEEALNLGSMTASEVFMSLRSKSILHLFASIGRSLGLKVYEHCLTTLKIPKPVLHGSDLLLMGLPQSGNSYYLLMQLDKDFRPLFNLLETQTESNGMSHAVGDVSHVVRFNKIDINEMLMVDDELNLSLLNSDKLNSLVFSSTSIQISECGLLHSGLEPALQTSEFSRSSFSSIVDEVFESNKDTSGNIVHSQSFSSSFSVPSFSHLNSLSNSNQGTKSGVVSSILDSSTPNFSKVSVVPFYPSGNSKVLLNAHSSSKPSFQKLSSSKSEQDLSSLKPPYSNQLGQFTAMDEDQTKLLTGSSSVIGGSHSGQLSSSLQAAVPRVAAPSSGVNGSKVSSYGHSVAVLRSTELNSLISTSLRQIPEFSLIHSSEHSGTPNKERASLKRSLADILKMMPSAKELEEDVRPLKRMKTLESSDSQGFSSFISSRTSKHTYGSLLAEGTHGIAPSNVYVSVLLHVVRHCSLCIKHARLTSQMDALDIPYVEEVGLRTSSSNLWIGLPFAQDSSWQHICLRLGKPGSMHWDVKINDLHFQELWELHRGSSSTPWGPGVRIANASDIDSHIHCDPEGVVLSYKTVETDSIQRLVSDLRRLSNARIFARDMRRLIGVRTDDKLDDSIANPDIKVQLQKSLTEPVDKLSEQMRRTFKIEAVGIMSLWFCYGSMPVTAHFVVEWEAGKVGCTMHVSPDHLWPHTKFLEDFINGGDVASFLDCIRLTAGPLLALAAAIPPARMSGPVSSGTPAPKQGSCIPSQGLAPNSSTSSAIVAATSGAPTGSSATAPFSSQSLLTAATLSAAGRCISGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGPAAGGSLPCPQFRPFIMEHVAQGLNALEPNIPAGANSGCHTSLNNSTQNSGSQAMVANSSRSIPRSGIVIGNQMAGNLNRVGNSMMSSSGLNSGVSGVPVRLTPGTGVPMHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFNHQQQQQTQTSAQEELSLPEISEICEYFSRRVASEPYDASRVASFITLLTLPVSVLREFLKLIAWKKGISQAHGGDLASAQRARIELCLENHMGSTYDENMDGSSVSKSNIHYDRSHNSVDFAVTFVLDPAHIPHVNAAGGAAWLPYCVSVRLKYAFGDSPHVSFLRMDGSHGGRSCWSRAEDWERCRQRLARAVEYANGNSMGDLTQGRLKLVVETLQKTLQASLQQLRDGST
Length1811
PositionTail
OrganismApostasia shenzhenica
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Apostasioideae> Apostasia.
Aromaticity0.07
Grand average of hydropathy-0.115
Instability index49.53
Isoelectric point7.00
Molecular weight198166.76
Publications
PubMed=28902843

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16816
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     465.88|     118|     118|     594|     711|       1
---------------------------------------------------------------------------
  507-  592 (81.81/53.56)	.....................................LLECEEALNLgSMTASEVFMSL.RSK.SI.LHLFASIGRSlGLkvyEHCL..TTLKIPKPVLH.G..S..DLLLMGL...PQSGNS..YYlLMQLDKDF..R.P
  594-  711 (194.93/141.12)	FNLLETQTESN.GM.SHAVGDV..SHVVRFNKIDINEMLMVDDELNL.SLLNSDKLNSLVFSSTSI.QISECGLLHS.GL...EPAL..QTSEFSRSSFS.SIVD..EVFESNK...DTSGNI..VH.SQSFSSSF..SVP
  713-  831 (131.49/92.02)	FSHLNSLSNSNqGTkSGVVSSIldSSTPNFSKVSVVPFYPSGN..SK.VLLNAHSSSKPSFQKLSS.SKSEQDL..S.SL...KPPYsnQLGQF.....T.AM.D..E..DQTKlltGSSSVIggSH.SGQLSSSLqaAVP
  839-  909 (57.65/34.86)	.................................GVNGSKVSSYGHSV.AVLRSTELNSLI..STSLrQIPEFSLIHS.SE...HSGT..PNKE..RASLKrSLADilKMMPSAK...E.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.12|      20|      21|    1250|    1269|       2
---------------------------------------------------------------------------
 1250- 1269 (37.86/20.81)	APKQGSCIPSQGLAPNSSTS
 1274- 1293 (33.98/17.87)	AATSGAPTGSSATAPFSSQS
 1408- 1423 (23.29/ 9.79)	..TQNS..GSQAMVANSSRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.17|      28|     118|    1221|    1249|       3
---------------------------------------------------------------------------
 1221- 1248 (48.30/25.07)	I.RLTAGPLLALAAAIPPARMSGPVSSGT
 1342- 1367 (49.33/25.84)	M.RCFAGDQVWLQPATPPK..GGPAAGGS
 1377- 1403 (35.54/15.90)	ImEHVAQGLNALEPNIPAGANSGCHTS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.18|      25|     118|    1030|    1092|       4
---------------------------------------------------------------------------
  328-  355 (41.65/11.66)	WE...GNSAGPdSGvpPFIRIEQGQDL..QIKC
 1045- 1074 (42.53/62.91)	WElhrGSSSTP.WG..PGVRIANASDIdsHIHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.34|      72|     720|     945|    1032|       6
---------------------------------------------------------------------------
  945- 1032 (101.18/107.71)	GSLLAEGTHGiapSNVYVSVlLH.vvrHCSlcIKHArLTSQMDALDIPYVEEVGlrtssSNLW......IGLPFAQDSSwQHIC.LRL.GKPGSMH.W
 1671- 1755 (110.16/68.59)	GSTYDENMDG...SSVSKSN.IHydrsHNS..VDFA.VTFVLDPAHIPHVNAAG.....GAAWlpycvsVRLKYAFGDS.PHVSfLRMdGSHGGRScW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.58|      20|      71|     290|     309|       7
---------------------------------------------------------------------------
  290-  309 (34.30/23.13)	DGITGQGVSSSVSQSAQDVE
  363-  382 (36.28/24.94)	DPITNKEAELSFDQSCIDVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16816 with Med14 domain of Kingdom Viridiplantae
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