<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16812

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEIGAEKKGTEEGDRQMDVADGPAPSPATVFRIRLKQPPSNTRYKMRVPELCRNFRLVLFLFLFCGSAVAWCGKLNVIACASETCARIPSSNVSPPFWIPIHILNPERPTECAVFNAKADSPRDYVQFIDWSPRSCPRALLIANFHGRITIWTQPSEGPLHLVRDASFWQCEYEWRQDLAVVTKWLSGTAQCRPLPSNPSSSSNMKSVFEEKFLLQQSPGSARWPNFLCVCSVFSSGLIQLHWAQWPPPQNGEVQKWFATSKGLLGAGPSGIMAADAIITDAGIMHVAGVPLVNPSTVVVWEVTPGPGSGFQTTAKYSTTNSVPPSVNPPCWTGFAPLAAYLFILQEYIIFEEKQGKRQTDREIIDAASLHCSPVSNFSAYVSPEAAAQCAATTTWGSGVTAVAFDPSRGGSVLAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSLQPVVLHPIFGNPASSFGGQPPMQTVWLTRVNKSIPPTDDMRNPQPCTSSSTISDERNSSDSSIERTKRLSFDPYDLPSDVRQLAQIVYSAHAGEVAVAFLRGGVHIFSGTNFSPVDSYHINVGSTIATPAFSSSSCCLASVWHDTSKDRTTLKIIRVLPPAVPSIQAKVSSATWERAIADRFWWSLLCGADWWDVVGCTQSAADDGTVSLNSMIAVLDADFHSLSSSQLRQLYGPSLDRIKCRVLEGTNAQDVRALVLDMQARLLLDMLGKGIESALINPTTLLPDPWHASSETLASIEADRMVVDQALVPSIQAYVDAVLDLASHFITRLRRYASFCRTLASHAVGATSGTNNARSIVGSPSQSSVSPATSQGQLSYSVASASSGSQSGSSNTGGNSQMQAWMQGAIAKISNNADGGSSSVPNPVTGPSPFVPISINTATFPGTPAVRLIGDCHFLHRLCQLLLFCLIFRRRLSPRFMALGVAAKIEEVQASRSGQLVAGAKGLEEGPPGKSLRLGSGNAGQGYTSEEVKVLFLILVDLCRRTAALQHPLPVSQVGSNNIVIRLHYIDGNYTVLPEIVEASLSPHMQNMPRPRGADAAGLLLRELELHPPAEEWHRRNMFGGPWSDPDELVPLDNTPKSKPFGSDTYAFDFAANCYDSSDTPCLWPRKRRLSERDAAFGLKTSVGLGTYLGIMGSRRDVITATWKTGLEGVWYKCVRCLRQTSAFAQPGSVAATNEREAWWIGRWAHACPMCGGTWVRVV
Length1208
PositionTail
OrganismApostasia shenzhenica
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Apostasioideae> Apostasia.
Aromaticity0.08
Grand average of hydropathy-0.111
Instability index49.22
Isoelectric point7.25
Molecular weight131165.51
Publications
PubMed=28902843

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16812
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     297.22|      92|     429|     285|     467|       1
---------------------------------------------------------------------------
  366-  467 (139.48/188.68)	DAASLHCSPvSNFSayVSPeAAAQCAATTTWGSGVTAVAFDPS.RGGSVLAVVIVEGQYMSPYDPDEGPSITgwrVQRWESSLQPVVlhPIFGNPAsSFGGQP
  801-  893 (157.74/61.64)	NARSIVGSP.SQSS..VSP.ATSQGQLSYSVASASSGSQSGSSnTGGNSQMQAWMQGAIAKISNNADGGSSS...VPNPVTGPSPFV..PISINTA.TFPGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.56|      40|     429|     285|     351|       2
---------------------------------------------------------------------------
   25-   64 (70.56/22.27)	PSPATVFRIRLKQPPSNTRYKMRVPELCRNF.RLVLFLFLF
  305-  345 (73.00/65.31)	PGPGSGFQTTAKYSTTNSVPPSVNPPCWTGFaPLAAYLFIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     265.68|      81|     145|     570|     654|       3
---------------------------------------------------------------------------
  570-  654 (136.60/84.68)	GSTIATpAFSSSSCCLASVWHDTSKDRTTLKIIR.VLPPA.VPSIQAKVSSATwerAIADRFWWSLLCGADWWDVVGCTQSAADDGT
  717-  799 (129.08/68.79)	GKGIES.ALINPTTLLPDPWHASSETLASIEADRmVVDQAlVPSIQAYVDAVL...DLASHFITRLRRYASFCRTLASHAVGATSGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.09|      65|     549|     482|     546|       5
---------------------------------------------------------------------------
  482-  546 (111.20/60.32)	PPTDDMRNPQPCTSSSTISDERNSSDSSIERTKRLSF.DPYDLPSDVRQLAQIVYSAHAGEVAVAF
 1032- 1097 (115.89/63.17)	PHMQNMPRPRGADAAGLLLRELELHPPAEEWHRRNMFgGPWSDPDELVPLDNTPKSKPFGSDTYAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.01|      16|     195|     914|     929|       6
---------------------------------------------------------------------------
  914-  929 (32.64/18.61)	CLIFR.RRLSPRFMALG
 1111- 1127 (29.37/16.04)	CLWPRkRRLSERDAAFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.91|      19|     941|       4|      24|       7
---------------------------------------------------------------------------
    4-   24 (30.93/26.04)	GAekKGTEEG..DRQMDVADGPA
  948-  968 (28.98/17.46)	GA..KGLEEGppGKSLRLGSGNA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16812 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LTRVNKSIPPTDDMRNPQPCTSSSTISDERNSSDSSIE
474
511










Molecular Recognition Features






MoRF SequenceStartStop




1) VFRIRLK
30
36