<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16789

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRFAAASCGAGASNNTSAGGVSTRENTRGDSSFTNPNFSLNSRRTLPLHSYKLKCEKEPLNFRLGPPDFYPQTPNCPEETVRGEYLQSGYKETVEGIEEAREIVLSQASYFTKPEVILKCKEAIRKRLRAINESRVQKRKVGQVYGLPLTGSLLVKSGVFPEQRHTSEDFRKKWIEALSLHHKRLRSLADQVPQGYRRKSLFEVLIRHNVPFLRATWFIKVTYLNQTRPSSSGVPSGAQDKVQISRSELWTRDIIEYLQQLLDDYSLKDGFGAPISNRDQSSSTVLPSSAQKTELSTSTSDTEEPSLQCKWWYMVHLLHWNNSEGLLLPSIVVDWVLSQLQEKDSAETLEMLLPVVYDVIEIIALSQTYTRLLVDIAVRSINDFSIGGLSTTETSKRSSLLSACVETLRYLILATPDTFVALECFPLPSCVHPNIYSGHITLKVPEDVGSLQTGKQDALFRYLSFGYAVYSIQRRAANLAKSATGGFQGHGAAKVVHLLDKAFVAGDVRLAYSAVFEDFSNFTMEERWMAEVSPSLQSCLKWIGTVDLPFICSVFFLCEWATCDYRNYRTNLSGSLKFTGLKDFSKVYVAVLLLKLKMEQMHISSLQTEKINSLASSGKALSLHDNIPSMEAQEKFSIRMNLKSAYHRRNRVDAFQSPGPLHDIIVCWMDQHEPGKGGSFKHLQLFIMELVQNGIFYPPAYVRQLIVSGIMDRNESLFDLEKRGRHRRILKQLPGTCLFDVLDEARILESSLLHEIVQIYSNERMLVLNGSSKCRSSHLGQNNDSYSPVLLQKKNGILLASKEISSSMLLESSRKKSNLSLNVTTSTGAKVKDKAAELKVLISALLRFPYSCSSQIESQVDESPGSLKRLSVSSGIRFDTSEGVLGSDDCREVKRQRLGDEKSSSLQVFSSIHSDDEETWWVKKGPKYLESMKVESISKLTKPVSRGRQKTVRKMQSLSQLAATRIESNHGASTSHLCDNKVSCPHHTAGVEGKIPKDVDRLNAIHLSDIGRSIKQLRLLEKRSVSIWLSASVRQLVDGSEKTVSKPRNGNGSFGTPLDDINMPRWKLGEEELSLILYILDSSSDLLLAVRLLLWLLPKVLNGSSNNGLVGRNIMMLNKSRENNVCQVGETFLLSALQRYENVIVASDLLPELLTAATNRNFAMLTPNGRSSSATSFVYARNLLKKYKDVGSVIKWEKNLRATCDQRLLSELDTNRPLDVDIGFSSGAPGGTTDFDEYIRQKISGRVSRTGLGMKEIVQRHVEEAMHYFYGKEKKPFAAANPKNFTEKWADAYQVAHEIVTGLADCIRQNGGAALEGDPSILASAISAIVGNIGSAVLKVPDFTGGNNQFLSTTFTSLNCVRYIVHIHIFSLCLLKEVLGERLGRILEIAVAVEASAVLSGYFSSISQRNQFQVSPENHDVNLNCSSETVNNSNFFGIRTAKATAAVSALVLGAIVHGVASLERMVTLFKLKEGLDVRQFIRSARSSSNGITRSVGNFKLEHSIEVCVHWFRLLVGNCVTVCDGFVSEFLGKSCITALSRMQRMLPLNLVLPPAYSIFAMVIWRPYILNSNIANREDIQPSNCMLSAVNEVIRHQPFRELCFRDTHAFYNLLATDVGDSEFAAMLELHNPDKQLKTRAFVPLRARLFLNSLIDCKMPSSMLLQENGSMMFEPAEPINFSEMEKNLLNQLVRVLETLQPAKFHWQWVELRLLLNEQAFLEKIESKDMSLVEAIRSLLPNADNFAVSESDKFLSEIILTRILVRPDAAPLYAEIVHLLGRSLEESLVMDIKWILAGSDVLSGRKSIRQQLLSVAQRKSLSIKPLFWKPWGWPNSTVDVTSSRVDKNKLESVFIEDGELVDDSPDAKRSGRINLLAVDPDGISSNQQYLTEKAIVELILPCLDRCSADLRNSFACELIKQMSMVEQQINLFTRGVNKQASVGHSGVDLSSNKGSSRKSMRGGSPGMGRRTAPVADASPPSAVALKSSIWLRLQFLVRLLPIVFSDRNMRQTLATIVLHLLGTRFVYEDADLSLSIQQLSPPMREMEQIEASAAALVDYSGDSLFDTFLCVLHGLLSSCKPSWLKLKSSSKLTTKSPRDFSAADPEAAENLQADLDSMELPATIRRRIQAAMPILPPSVSLPPRSHTLPTPTSLSSPFPPSASIPSPLQRVTPPIRPPVKTKAPPSTQDVDGEIDPWTLLEDGTACAASSAAGSSAGSVSGDHSNLKACCWLRGAVRVRRTDLTYIGSLDDDS
Length2250
PositionKinase
OrganismApostasia shenzhenica
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Apostasioideae> Apostasia.
Aromaticity0.07
Grand average of hydropathy-0.180
Instability index47.94
Isoelectric point8.66
Molecular weight249995.53
Publications
PubMed=28902843

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16789
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.25|      24|      46|     165|     188|       1
---------------------------------------------------------------------------
  165-  188 (42.78/32.28)	RHTSEDFRKKW.IEALSLHHKRLRS
  208-  232 (39.47/29.07)	RHNVPFLRATWfIKVTYLNQTRPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.39|      17|      50|    1097|    1118|       2
---------------------------------------------------------------------------
 1097- 1118 (25.26/24.20)	LLPKVLNGSSNnglvgRNIMML
 1150- 1166 (30.14/16.00)	LLPELLTAATN.....RNFAML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.17|      44|     199|    1946|    1991|       3
---------------------------------------------------------------------------
 1946- 1991 (67.65/49.83)	LSSNKGSSrKSMrGGSPGMGRRT....APVADASPPSAVALKSSI..WLRLQ
 2151- 2198 (62.21/36.68)	LSSPFPPS.ASI..PSP.LQRVTppirPPVKTKAPPSTQDVDGEIdpWTLLE
 2200- 2230 (35.30/16.41)	.............GTACAASSAA....GSSAGSVSGDHSNLKACC..WLR..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.29|      15|      50|     236|     254|       4
---------------------------------------------------------------------------
  236-  254 (18.35/31.49)	PSGAQdKVQISRSelwTRD
  288-  302 (26.95/20.22)	PSSAQ.KTELSTS...TSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.73|      77|     199|    1220|    1300|       5
---------------------------------------------------------------------------
 1220- 1300 (126.71/106.74)	DVDIGFSSGAPGGTTDFDeyIR.QKISGRVSRTGLGmkEIVQ..RHVEEAMHYFYGKEK...KPF..AAANPKNFTEKWADAYQVAHEI
 1421- 1505 (108.02/77.61)	DVNLNCSSETVNNSNFFG..IRtAKATAAVSALVLG..AIVHgvASLERMVTLFKLKEGldvRQFirSARSSSNGITRSVGNFKLEHSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.37|      87|     199|     594|     680|       6
---------------------------------------------------------------------------
  594-  680 (151.30/93.44)	LLKLK....MEQMHISS...LQTEKINSLASSGKALSLHDNIPSMEAQEKFSIRMNLKSAYHRRNRVDAF..QSPGPLHDIIVCWMDQHEPGKG..GS
  791-  888 (117.07/70.44)	LLQKKngilLASKEISSsmlLESSRKKSNLSLNVTTSTGAKVKDKAAELKVLISALLRFPYSCSSQIESQvdESPGSLKRLSVSSGIRFDTSEGvlGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.50|      63|      65|    1630|    1694|      15
---------------------------------------------------------------------------
 1630- 1694 (102.73/65.45)	NPDKqlKTRAFVPLRARLFLNSLIDCKMPSSMLLQENGSMMFEPAEPINFSEMEKNLLN.QLVRVL
 1698- 1761 (99.77/58.16)	QPAK..FHWQWVELRLLLNEQAFLEKIESKDMSLVEAIRSLLPNADNFAVSESDKFLSEiILTRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.86|      28|      47|     495|     523|      17
---------------------------------------------------------------------------
  495-  523 (42.04/32.05)	KVVHLLDKAFVAGDVRLAYSAVFeDFSNF
  542-  569 (55.82/38.54)	KWIGTVDLPFICSVFFLCEWATC.DYRNY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16789 with Med12 domain of Kingdom Viridiplantae
Unable to open file!