<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16788

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKHIRCLAGDDIERVLRQQSRKFITKGLPVIVSPNGMRGRLTGCCPVDIVNQLYARLKASDEIPAGAPSIMRSAVCLFRGQKCFVEVTLGYPSCSDRSAEAICSDNVNAVCLRSEDPCTVSSGKCHHTGSFPKLERTFVYPVEFVLVPVFDRAFARSSFKRFFLQILAGTSPFELWPFWNFSTLSEHRSQFLEELAIDFGGTGLKRKYNSSSNSTCSSTSSTSSTSSASDHAAFTGATDLEADADSLTSRQSGLSSNDQLDNDGNRMVAKRIRSSVIDTFGQVTTVGSETAQSLTKSEYSVVDVVDVAGGGSANAQVGSNWDWEEDERGIGVDIQVLLSEFGDFGDFFESDVLTFGEPPGTAESQALVFPSIEGGDLSGSPYTMGIDSPDQKISTVGLTSFENFNQSSVTSMEDTQSICVDTAKDSKASATTSHTLVLFTGKFDYLKKAEAVLTFAPEYAAVEMSSNEFCTSIFRNPYLPCSKRVESSQISSNAYIYSAAPPLIDDSEENPEKSCKVKLGNGGYGTTGLSGKLYTQVQSGTKEVHKRLFNVDMPTHKGQNPSSLCVKTSSSGISVLPLMNDKTIEAGHFLLSLKTVLATEIECIMFQAAMCRIRHMLVSFNCQVPLRLNKRSENAMLDVISCDASSIHDVLPTKHEARKNDALPVRIAGDVDVGMHDASVAAPVGVWRPVGVPKGTEPSNKCMFEKSPSLQNNSANEESVHGQRQALQEFLDALGFLVQQSASFVDVALDTDDTVGPYSWLALQEQQRRGFSCGPSMVHAGCGGILATCHYVDIAGVDLMDPLSADVQVSTVISMLQSDIKSALKSAFASLDGPLSLTEWCRGRHQSGDSGTTGDGYSFQCNLSEAKDSLSNVTMGGDPISSPQSTSSSREGIRIDDSSQKRLNQEVCSSDSETQKLNSRLRPTLSVLPLPLLLVGYQDDWLKTSVSCLPLWEKAPLEPYALPKPVSYFAVCPDIDLLTSAATDFFQQLGTVYEACKLGSHTPHNTGSIVESSPGKLSSSGLVLVNCPQELKALSGTMPISSINDYFVALSKSWNLTSYVNSLKKVLLDLHFTVTSSTNQKEGNTGPCMVVYVVCPFPGHAAVLQTVIQCSKAIGSVALSLDKEKQSLLHSHVAKALCFSAAADEASVSSVVMLSGFRIPKLVLQIVTVDSLLRLNRPAKELAILKELAFTVYNKVRRIPRAVSSAADIPLNVPSRGQSTLMHVNSPIPGIWKDCLAPRISSSVLARETELDSALRPATWDNSWQTRVGGLNFDSSRSVELLFQDDPRYLFEPLFILAEPGFVEHEPSGSKSAAEDNSCIYMQTSTSGGATEIGKGSLVDGSEHDCRPANLHCCYGWTEDWCWLICIWTDSRGELLDCGIFPFGGISSRQDTKVLQNLFIQVLHHSCQILSSLSDLGNIKQRDMIITRIGCFFELECQEWQKAIYSVGGNDVKKWPIQLRRAIPDAVLANNGTSLEQQEMGLIQERTLPSSPSPSLYSTQSKSSFIKGSLGQANAKKPMLGGQTGLDSSKGLLHLIRSISLVSVSMDHSLHLIIPAHFSSAGGQNNVSTSFPSYLEGFIPVKSLGSLSTSYLLIPSPSMRFLPPSPFQLPTCLTSESPPLTHLLHSKGSAIPQSTGFVISKSVPTMRRDPVDPLKEDWPSILAVSLVDHYGGGRSSLVQEKLTGRGSTGSTAAANKQGRSIGPEAYEMEAHLVLESVAAELHALSWMTVSPLYVDRRSALPFHCDMLLRLRRLLHYADKEFSRPPSDQPDLL
Length1772
PositionKinase
OrganismApostasia shenzhenica
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Asparagales> Orchidaceae> Apostasioideae> Apostasia.
Aromaticity0.07
Grand average of hydropathy-0.141
Instability index50.99
Isoelectric point5.70
Molecular weight192102.42
Publications
PubMed=28902843

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16788
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.16|      48|     123|    1484|    1542|       1
---------------------------------------------------------------------------
  205-  260 (67.81/28.56)	KRKYNSSSNSTCSSTSSTSSTSSASdhaafTGATDLEadaDSLTSRQSGLSSNDQL
 1485- 1532 (82.35/50.30)	ERTLPSSPSPSLYSTQSKSSFIKGS.....LGQANAK...KPMLGGQTGLDSSKGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     635.57|     225|     349|     761|     999|       3
---------------------------------------------------------------------------
  282-  520 (222.24/137.58)	................................................QVTTVGS...ETAQSLTKSEYSV.VDvvdvaGGGSANAQV.GSNWDWEEDERGIGVDIQVLLSEFGDfgdfFESDVLTFGEPPGTAESQALVFPSIEGGDlsgspytmgidspdqkistvglTSFENFNQSSVTSMEDTQsicvdtakdsKASATTSHTL......VLFTG.KFDYLKKAEAVLTFApEYAAVEmssnefctsifrnPY.LPcsKRVESSQISSNA.YIYSAAPPLIDDSEENPEkSCkvKLG
  539-  615 (53.81/24.26)	SGTKEVHKRLFNVDMPT.HKGqNPSSL..CVKTSSSGISVL.PLMNDKTIEAGHFLL......SLKTVLATeIE.....CIMFQAAMCRIRH.................................................................................................................................................................................................................
  761-  999 (359.53/272.28)	LALQEQQRRGFSCGPSMvHAG.CGGILatCHYVDIAGVDLMdPLSADVQVSTVISMLqSDIKSALKSAFAS.LD.....GPLSLTEWCRGRHQSGDSGTTGDGYSFQCNLSEAKD....SLSNVTMGGDPISSPQSTSSSREGIRIDD......................SSQKRLNQEVCSSDSETQ..........KLNSRLRPTLsvlplpLLLVGyQDDWLKTSVSCLPLW.EKAPLE.............PYaLP..KPVSYFAVCPDIdLLTSAATDFFQQLGTVYE.AC..KLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     213.85|      86|     418|    1112|    1229|       5
---------------------------------------------------------------------------
 1049- 1160 (120.59/103.64)	ALSKSWNLTSYvNSLKKVlldlHFTVTSSTN..QKEGNTGPCMVVYVVCPFP......................................................................................................................................................................................................................................................................................................ghaavlqtviqcsKAIGSVALSLDkekqsllHS.HVAKALCFSAAADEASVSSVV..MLSGFrIP
 1183- 1229 (49.63/21.17)	AILKELAFTVY.NKVRRI....PRAVSSAADipLNVPSRGQSTLMHVNSPIP.......................................................................................................................................................................................................................................................................................................................................................................
 1537- 1580 (43.62/11.01)	....................................................giwkdclaprisssvlareteldsalrpatwdnswqtrvgglnfdssrsvellfqddprylfeplfilaepgfvehepsgsksaaednsciymqtstsggateigkgslvdgsehdcrpanlhccygwtedwcwliciwtdsrgelldcgifpfggissrqdtkvlqnlfiqvlhhscqilsslsdlgnikqrdmiitrigcffelecqewqkaiysvggndvkkwpiqlrraipdavlanngtsleqqemgliqertlpsspspslystqskssfikgslgqanakkpmlggqtgldsskgllhliRSISLVSVSMD.......HSlHLIIPAHFSSAGGQNNVSTSFpsYLEGF.IP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.40|      20|     688|    1023|    1043|       9
---------------------------------------------------------------------------
 1023- 1043 (31.33/23.85)	VLVNCPQELKALSgTMPISSI
 1713- 1732 (35.07/21.46)	VLESVAAELHALS.WMTVSPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16788 with Med13 domain of Kingdom Viridiplantae
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