<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16778

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAQQQLQKYELTPPKNLVRLHKESIELGFPDFYPPKSGQDEDQMTEENKPDTLKNLGDFMTDVMKRKNETTFQGSSQFMGPTIVWVTVEERDKWLRDLAGNVPLKILARSVPKGVDGKDLLESVTLYRVPLARATWFTKVVGINKIIQRGNTDYTKEWTSIFYHFIRDQSLSHDPDKWRYSILLAKWQFDEQLLDQRLLRFTLEQLDEADHCQTPMWLWLVQQFLSEFQRSRTLMRLLIEIIIKKLQDIHQHPHIIIKLELVVKLLKNMLHTLFITTPDMFVFPVCWNTYKDLLRVVLVDDDSKTDPPNLKHQRERYFEAVRSRNEIFDDKKINPLGMSNARDALDSRMISILDKITYRIDYHNITAEYFRTNSNFQMMEREVSRHIHTLCRWTITPFREGDFRAYSLNFWTYTHLELFGVLTKNGHFSYQRYLQRLIARGDVRPEKRTTERSLRHLRYVKWFAIYETDLHDLNHSINQRWHILYGINSKDTSDKNTTDTLSNIVSEKLPNVFSPKAKDMNAPIVDDPGSDFNCLINFDDSSLEFIQNATKFCQFRVVQEFLIPSVKRFVQNTPIDDTNWKSLAEPGSSLLNARQLATIVQFIELTKDYSSLLELIIWVLENSMERTLFPLIVDTIKRYEMIWDAMGKSDGVFDVLMKKNDQLREKRATEICIVKYLSGVIQDPEKKSKLDHDYSQFPTKSPLSVTISRNRDRLGQDVKNLLNRTRGFELSIASNIDSRWFQSDSVDVYLHAILESCTDVIHRHLQNYSEWTDARKLLDVIGDLLKEVGDRTTDGFDAVFSKKWLNYYIRADDDDSLLRQDRFLIFFTVLVVRHLVKIETILEHLVEKNLIRFSDKLLNKKQLDSNEIIECRNLAILLRIFLIHKNVSSGIPLTTMEIQRLQFICESFIHNNDFTIISNVFQKLAIIESSLGSNDDLAIELQQLRMDFSQVYWFKQLCIANIDNVYDRFVKGTKKQNNSKEVKKLMIEIVRSGLGNFSYDNDVMNGYSSSLCFKNLERIFSTVNLWNIQKSRIEFFMCMDQIMLLDSSSNGSLHSNMELDGDLIMGGSEEDLNNIKSRVIEYFWEELVLKGNNDCLIISHIIRGIREDVAAELLEHGLTVLKRCGELIIGIEEVFRALLLSVRDNKKEFSEALINQIQKIIDENKDHTFVPCIMTRIKLFVLVANVLAARVTAVVTTNSIEFANRVPEYNLIMKWVVTLINLLCSERIHQNGGGADNFDLILDIVSFLIDEMGKIPRAIVVAELKVNNKFLFFT
Length1274
PositionKinase
OrganismRhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194) (Arbuscular mycorrhizal fungus) (Glomus intraradices)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.10
Grand average of hydropathy-0.260
Instability index38.05
Isoelectric point6.27
Molecular weight148731.30
Publications
PubMed=30271968

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16778
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.15|      18|      22|     899|     916|       2
---------------------------------------------------------------------------
  899-  916 (34.00/19.44)	QRLQFICESFIHNNDFTI
  922-  939 (29.15/15.69)	QKLAIIESSLGSNDDLAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.09|      22|      23|    1093|    1114|       3
---------------------------------------------------------------------------
 1075- 1096 (34.54/19.58)	IKSRVIEYFWEELVLKGNNDCL
 1097- 1118 (34.55/19.59)	IISHIIRGIREDVAAELLEHGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.83|      18|      23|     531|     548|       4
---------------------------------------------------------------------------
  531-  548 (32.87/20.70)	DFNCLINFDDSSLE.FIQN
  554-  572 (26.96/15.61)	QFRVVQEFLIPSVKrFVQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.02|      20|      26|     301|     324|       5
---------------------------------------------------------------------------
  301-  324 (26.26/35.39)	DDSKTDPpnLKHQRERyfEAVRSR
  329-  348 (35.76/26.08)	DDKKINP..LGMSNAR..DALDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     405.88|     139|     618|      39|     202|       6
---------------------------------------------------------------------------
   39-  202 (215.56/192.52)	QDEDQMTEenKPDT....LKNLGDFMTDVMKRKNETtfQGSSQFMGPTIVWVTV.EERDKwLrdlagnvplkilarsvpkGVDGKDLLESVTLYRVPLAR...ATWF..TKV........VGINKIIQRGNTDYTkEWTSI..FYHFIRDQsLSHDPDKWR...YSILLAKW.QF......DEQLL..DQRLLRFT
  658-  828 (190.32/120.76)	KKNDQLRE..KRATeiciVKYLSGVIQDPEKKSKLD..HDYSQFPTKSPLSVTIsRNRDR.L..................GQDVKNLLNRTRGFELSIASnidSRWFqsDSVdvylhailESCTDVIHRHLQNYS.EWTDArkLLDVIGDL.LKEVGDRTTdgfDAVFSKKWlNYyiraddDDSLLrqDRFLIFFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.41|      15|      85|     376|     395|       8
---------------------------------------------------------------------------
  376-  394 (24.71/26.59)	FqmmeREVSRHIHTLCRWT
  398-  412 (29.70/14.10)	F....REGDFRAYSLNFWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.88|      12|      16|     461|     472|       9
---------------------------------------------------------------------------
  461-  472 (22.90/13.69)	KWFAIYETDLHD
  480-  491 (22.98/13.77)	RWHILYGINSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.67|      17|     605|     629|     648|      12
---------------------------------------------------------------------------
  629-  648 (28.19/31.13)	FPLIVDTIkryEMIWDAMGK
 1238- 1254 (30.48/22.07)	FDLILDIV...SFLIDEMGK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16778 with Med12 domain of Kingdom Fungi
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