<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16778

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAQQQLQKYELTPPKNLVRLHKESIELGFPDFYPPKSGQDEDQMTEENKPDTLKNLGDFMTDVMKRKNETTFQGSSQFMGPTIVWVTVEERDKWLRDLAGNVPLKILARSVPKGVDGKDLLESVTLYRVPLARATWFTKVVGINKIIQRGNTDYTKEWTSIFYHFIRDQSLSHDPDKWRYSILLAKWQFDEQLLDQRLLRFTLEQLDEADHCQTPMWLWLVQQFLSEFQRSRTLMRLLIEIIIKKLQDIHQHPHIIIKLELVVKLLKNMLHTLFITTPDMFVFPVCWNTYKDLLRVVLVDDDSKTDPPNLKHQRERYFEAVRSRNEIFDDKKINPLGMSNARDALDSRMISILDKITYRIDYHNITAEYFRTNSNFQMMEREVSRHIHTLCRWTITPFREGDFRAYSLNFWTYTHLELFGVLTKNGHFSYQRYLQRLIARGDVRPEKRTTERSLRHLRYVKWFAIYETDLHDLNHSINQRWHILYGINSKDTSDKNTTDTLSNIVSEKLPNVFSPKAKDMNAPIVDDPGSDFNCLINFDDSSLEFIQNATKFCQFRVVQEFLIPSVKRFVQNTPIDDTNWKSLAEPGSSLLNARQLATIVQFIELTKDYSSLLELIIWVLENSMERTLFPLIVDTIKRYEMIWDAMGKSDGVFDVLMKKNDQLREKRATEICIVKYLSGVIQDPEKKSKLDHDYSQFPTKSPLSVTISRNRDRLGQDVKNLLNRTRGFELSIASNIDSRWFQSDSVDVYLHAILESCTDVIHRHLQNYSEWTDARKLLDVIGDLLKEVGDRTTDGFDAVFSKKWLNYYIRADDDDSLLRQDRFLIFFTVLVVRHLVKIETILEHLVEKNLIRFSDKLLNKKQLDSNEIIECRNLAILLRIFLIHKNVSSGIPLTTMEIQRLQFICESFIHNNDFTIISNVFQKLAIIESSLGSNDDLAIELQQLRMDFSQVYWFKQLCIANIDNVYDRFVKGTKKQNNSKEVKKLMIEIVRSGLGNFSYDNDVMNGYSSSLCFKNLERIFSTVNLWNIQKSRIEFFMCMDQIMLLDSSSNGSLHSNMELDGDLIMGGSEEDLNNIKSRVIEYFWEELVLKGNNDCLIISHIIRGIREDVAAELLEHGLTVLKRCGELIIGIEEVFRALLLSVRDNKKEFSEALINQIQKIIDENKDHTFVPCIMTRIKLFVLVANVLAARVTAVVTTNSIEFANRVPEYNLIMKWVVTLINLLCSERIHQNGGGADNFDLILDIVSFLIDEMGKIPRAIVVAELKVNNKFLFFT
Length1274
PositionKinase
OrganismRhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194) (Arbuscular mycorrhizal fungus) (Glomus intraradices)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.10
Grand average of hydropathy-0.260
Instability index38.05
Isoelectric point6.27
Molecular weight148731.30
Publications
PubMed=30271968

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16778
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.15|      18|      22|     899|     916|       2
---------------------------------------------------------------------------
  899-  916 (34.00/19.44)	QRLQFICESFIHNNDFTI
  922-  939 (29.15/15.69)	QKLAIIESSLGSNDDLAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.09|      22|      23|    1093|    1114|       3
---------------------------------------------------------------------------
 1075- 1096 (34.54/19.58)	IKSRVIEYFWEELVLKGNNDCL
 1097- 1118 (34.55/19.59)	IISHIIRGIREDVAAELLEHGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.83|      18|      23|     531|     548|       4
---------------------------------------------------------------------------
  531-  548 (32.87/20.70)	DFNCLINFDDSSLE.FIQN
  554-  572 (26.96/15.61)	QFRVVQEFLIPSVKrFVQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.02|      20|      26|     301|     324|       5
---------------------------------------------------------------------------
  301-  324 (26.26/35.39)	DDSKTDPpnLKHQRERyfEAVRSR
  329-  348 (35.76/26.08)	DDKKINP..LGMSNAR..DALDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     405.88|     139|     618|      39|     202|       6
---------------------------------------------------------------------------
   39-  202 (215.56/192.52)	QDEDQMTEenKPDT....LKNLGDFMTDVMKRKNETtfQGSSQFMGPTIVWVTV.EERDKwLrdlagnvplkilarsvpkGVDGKDLLESVTLYRVPLAR...ATWF..TKV........VGINKIIQRGNTDYTkEWTSI..FYHFIRDQsLSHDPDKWR...YSILLAKW.QF......DEQLL..DQRLLRFT
  658-  828 (190.32/120.76)	KKNDQLRE..KRATeiciVKYLSGVIQDPEKKSKLD..HDYSQFPTKSPLSVTIsRNRDR.L..................GQDVKNLLNRTRGFELSIASnidSRWFqsDSVdvylhailESCTDVIHRHLQNYS.EWTDArkLLDVIGDL.LKEVGDRTTdgfDAVFSKKWlNYyiraddDDSLLrqDRFLIFFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.41|      15|      85|     376|     395|       8
---------------------------------------------------------------------------
  376-  394 (24.71/26.59)	FqmmeREVSRHIHTLCRWT
  398-  412 (29.70/14.10)	F....REGDFRAYSLNFWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.88|      12|      16|     461|     472|       9
---------------------------------------------------------------------------
  461-  472 (22.90/13.69)	KWFAIYETDLHD
  480-  491 (22.98/13.77)	RWHILYGINSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.67|      17|     605|     629|     648|      12
---------------------------------------------------------------------------
  629-  648 (28.19/31.13)	FPLIVDTIkryEMIWDAMGK
 1238- 1254 (30.48/22.07)	FDLILDIV...SFLIDEMGK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16778 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFYPPKSGQDEDQMTEENKPDTLKNLGDFM
31
60










Molecular Recognition Features






MoRF SequenceStartStop




1) LGFPDFYP
27
34