<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16765

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTTLNTTSTTSTLWSHTDTDIERLYYELCYRKAPRRIAWSTQNIIAWSPHPNDNLDTKFSRYCPNVGIYSPCRGIDANGPAWSFINKEYLSLFDRVENYHRFGDVITDLVWNQTGSALASIDQRGKIAIWTMNNFINQWKCICNVNLGESVIEFTWLDSARLYSREHVPQSSGYGKSSAIYKRGSFKGPRNQFGEFAFITVTTDGKVAVWYQRGKKFFSKIITHLRYPSKRISHVDIILNSDGNYTLATYCPEFLPKLVMFYEIKINMLSLQVSCRPIANVHLTNPSLSVERSPVLHLKLISNTQSHGVRLIIVTAEKKGNNVFNSSIATWEIDKITPQPLDSLTENAMEIDMPLPSIHLVASEHLDQKLVTNIWIQDDELFLGLSDGQVQFRNCNTLQVLSQEQIGLKHFKDCNFPKYSTWVPSNCGHEELSTRADAIIEFATSPNGTLFLCRRASGKLDCLDIADKDVFSNFGLLDGICAASSSANKLTLSILNNIDHTDLENIIKKYANTLEGVGMGKDLLEHTLKETFTNISSVFSDGLETSASSDFLSRLLGIQLSLLKSCQRDNINYLNTLYFLHLRALEAIFQNNVSSDGTFSLDSLKSLVSLTSWIIDFSVYFVQNIYSLVTQGDALLSEKSHIVLLYNSTSRTAFKNLLSLVKKFKDNVNSLAASSPHISNIQEMNGTLQYLFDSWPLKLESLELFIKDTGIITDKVTDKWMKDKNNPQWAKYEIIFTSKVPKALSETLPELKEIFKNRFTSENDIKFYIYDTKWIYSESVDIILKSRTIKDRICARCGYYSAALDVQNTRWAKGYTRSCVCGGLWIDIKEK
Length831
PositionTail
OrganismRhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194) (Arbuscular mycorrhizal fungus) (Glomus intraradices)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.11
Grand average of hydropathy-0.208
Instability index31.01
Isoelectric point7.50
Molecular weight94397.50
Publications
PubMed=30271968

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16765
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.81|      10|      27|     175|     184|       1
---------------------------------------------------------------------------
  175-  184 (18.42/10.82)	GKSSAIYKRG
  205-  214 (20.40/12.72)	GKVAVWYQRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.37|      20|      22|     776|     797|       2
---------------------------------------------------------------------------
  776-  797 (27.33/24.14)	YSESVDiILKSRTIK..DRICArC
  800-  821 (31.04/17.66)	YSAALD.VQNTRWAKgyTRSCV.C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.01|      26|      27|     498|     524|       3
---------------------------------------------------------------------------
  498-  515 (23.20/10.92)	..................ID.HT...DLENIIKKYANTLE
  517-  544 (30.04/18.54)	VGMGKDLL............eHTlkeTFTNISSVFSDGLE
  545-  577 (25.78/ 9.77)	TSASSDFLsrllgiqlslLK.SC...QRDNI..NYLNTL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.20|      14|      89|      36|      55|       4
---------------------------------------------------------------------------
    8-   21 (25.74/14.41)	STTSTL.WS.HTDTDI
   40-   55 (18.46/15.20)	STQNIIaWSpHPNDNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.90|      21|      22|     695|     716|       5
---------------------------------------------------------------------------
  695-  716 (30.82/22.48)	WpLKLESLELFIKDTGIITDKV
  720-  740 (40.08/24.21)	W.MKDKNNPQWAKYEIIFTSKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.33|      19|      27|     445|     465|       6
---------------------------------------------------------------------------
  445-  465 (27.06/25.77)	SPNGTL.FLCrRASG...KLDcLDI
  472-  494 (24.27/12.50)	SNFGLLdGIC.AASSsanKLT.LSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.03|      49|     398|     233|     288|       7
---------------------------------------------------------------------------
  233-  288 (80.09/85.99)	SHVDIILNSdgnytlaTYCPEFLPKLVMFYEIKINMLSLQVSCRPIANVHLTNPSL
  640-  688 (80.93/67.86)	SHIVLLYNS.......TSRTAFKNLLSLVKKFKDNVNSLAASSPHISNIQEMNGTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.71|      28|     160|     582|     614|      11
---------------------------------------------------------------------------
  582-  614 (40.61/36.21)	LRALEAIFQNNVSSDgtfslDSLKSLVSLTSWI
  748-  775 (51.09/32.34)	LPELKEIFKNRFTSE.....NDIKFYIYDTKWI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16765 with Med16 domain of Kingdom Fungi
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