<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16763

Description Cyclin-dependent kinase 8/11
SequenceMLAEFRTKRETERVRVEDKYQVIGFISSGTYGRVYKAKAKKTVKSADGEEKELVYAIKKFKPDKEGDTHTYTGISQSACREISLCRELQHQNIISLQEVLLEDNSIHMVFEYAEHDFLQIIHHHSQQERKPIPEFTIKSFLWQLLNGVAYLHANWVLHRDLKPANILVTADGVVKIGDLGLARIYERPLQPLFNGDKVVVTIWYRAPELLLGSRHYTKAIDIWAVGCIFAELLTLRPIFKGEEAKMDNKKNVPFQKNQLNKIFDVLGKPTKEQWATIEQQPEYPNLASFRSSPNRLREFYNNSCSSNSDAGFALLSAMLEYDPVKRITAEDALLHPYFSEEPKPSMDSFEGQHYQYPLRAVKSEDNDMKVPPTANSAVQGQGGTTHGGTRGKHGHSGKDEGRPSKRGREVQKKSGK
Length416
PositionKinase
OrganismRhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194) (Arbuscular mycorrhizal fungus) (Glomus intraradices)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.09
Grand average of hydropathy-0.618
Instability index41.89
Isoelectric point8.84
Molecular weight47360.24
Publications
PubMed=30271968

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16763
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.06|      11|      17|     313|     323|       1
---------------------------------------------------------------------------
  313-  323 (19.11/13.21)	ALLSAMLEYDP
  332-  342 (20.95/15.16)	ALLHPYFSEEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.34|      16|      21|     184|     203|       2
---------------------------------------------------------------------------
  156-  174 (22.49/ 7.36)	VLHRDLKPaniLVTADGVV
  184-  199 (29.85/24.26)	IYERPLQP...LFNGDKVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16763 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALLHPYFSEEPKPSMDSFEGQHYQYPLRAVKSEDNDMKVPPTANSAVQGQGGTTHGGTRGKHGHSGKDEGRPSKRGREVQKKSGK
332
416










Molecular Recognition Features






MoRF SequenceStartStop




1) GQHYQYPLRAVK
2) HGGTRGKHGHSGKDEGRPSKRGREVQKKSGK
351
386
362
416