<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16762

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDSSSLTKISPIESAVTNVLTVSNIIKVGWCKYTYSCSGDQLRSFITSTPSSEVENISRIDDPIVVNYMVLLEKGIPCTWKYKDENEKNFEILFTDKMLVRELYVFWLEDAEEHPSTLDNLTRLESLEVTEKGTFTWEDFESSAIQFDLFIRSIKNLISRTLIGKGAVPMGELHLFPKFQQKIYECILSCKYNIHITSTNLVVKPVVRYQSLRPLAPSDFSKSEEVKLEVVKVLLAPSGIRGNLLPYRRYEADDIAAVLNEFRTLFGLDLSNLEEESSIPTLVHVQITHDNLTKDFPYPAKGVYVITDSNNIYRCEARDSGMVPEIFNNFVDYSSEQKLKPSKWWSYNDHSKEAVQILKLRNSVDLGTTSPGVDTMTPNTPGMGNGTSSASSPGHNLGTGRSSKKRPLETKAYPSPPDAIQSNEIQMPPPQNDAELTDEIMGMDVGSYEFDYYMYDDITDADFDNCDNKDSQAISPTTNDQTPGNISIVNEDSPSVGQNQISLAKHRQQQIDRDLQFEIGKVKLRYCPEDYTPLMFHNEVDMTKYMPGGKFCRATNRKKRKRGFFYTPDYEPAWVLEAKKPKTSDDDLKPSQKRNEEELEYYSSESDIDYTSESCESESESDIESNDESEVEWKNEIGNSKVSNHRELGFLNAGRLSMIFNIYVLCERRQLRRLTDCEVCNDTQSEMALQFLREQIAGGSYPFGAGIHGEGESTFEFIETRRRILENLSDDLPTSSALPSEQQEITMSLKNVIEKISVKFPRPENHPQLSVNGPLSVQDYYNLNGVQFKINEGVESNFQVLKTPDIIVCADKFLIETSPEIVKYWDKHNLTPFAGKKDVKYFVFCPEGDSLYYHVKNFFNELRVQYELHCVLGMHEPGIIQNPNYNFKQGIIPIRLKPQNRNETELDRMIRSYKSTCEEFGSSLASHIANFEKTQLVIYLINPFNHLTAYYDIFKCYAKFYTSLEKSLKSVSTKNILNYVMPQLIPIEHVVRFGENCIRPFRQRPVLKDLAFSVYTRSKSYRPLFILPKPSVVSVGFQLIKKAPPVRELIEYNKILHMSYGFSFDQRRLVMVWVDMEGKKLGSYSTPTYESKNQISLESLYKETWGRTCAFNKHIGGYKQIIITKTGVMTQEEKNLWIKVTEGKVPIFSVNLDTTLDIKPTLDGNGQSSKICGMVLNHPIPVNDFRPEATGFLVEVNNNETVSNTIQVDLLYNPKNEKKNTEIMWDVLNQFHVLSFMEVTTTHMCLPIHVLMVERCCRVYLGVPA
Length1265
PositionKinase
OrganismRhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194) (Arbuscular mycorrhizal fungus) (Glomus intraradices)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.10
Grand average of hydropathy-0.448
Instability index47.65
Isoelectric point5.48
Molecular weight144714.58
Publications
PubMed=24277808
PubMed=30271968
PubMed=29355972

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16762
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     310.20|     100|     109|     889|     997|       1
---------------------------------------------------------------------------
  893-  997 (160.83/133.38)	PIRLKPQNRnETELDRMIRSyKSTCEEFGSSLASHIA.NFE...KTQLVIYLI..NPFNHLTAYYDI.FKCYAKFYTSLE.KSLKSVSTKnilNYVMPQLIPIEHVVR..FGENC
 1000- 1109 (149.38/97.89)	PFRQRPVLK.DLAFSVYTRS.KSYRPLFILPKPSVVSvGFQlikKAPPVRELIeyNKILHMSYGFSFdQRRLVMVWVDMEgKKLGSYSTP...TYESKNQISLESLYKetWGRTC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.49|      20|     109|     196|     232|       3
---------------------------------------------------------------------------
  206-  227 (29.43/43.46)	VVRYQSLRPLAPsdFSKSEEVK
  821-  840 (37.06/10.91)	IVKYWDKHNLTP..FAGKKDVK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.82|      43|     103|     739|     785|       5
---------------------------------------------------------------------------
  739-  785 (65.63/53.71)	PsEQQEITMSLKNVIEKISVKFprpENHPQLSVNGPLSVQD.YYNL.NG
  846-  890 (72.19/45.09)	P.EGDSLYYHVKNFFNELRVQY...ELHCVLGMHEPGIIQNpNYNFkQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.71|      22|     780|     422|     445|       7
---------------------------------------------------------------------------
  422-  445 (34.11/25.36)	SNEIQ...MPPPQNDAELTdEIMgMDV
 1203- 1227 (37.60/18.92)	SNTIQvdlLYNPKNEKKNT.EIM.WDV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.82|      26|     150|     393|     418|       8
---------------------------------------------------------------------------
  393-  418 (47.65/26.42)	PGHN...LGTGRSSK.KRPLE.....TKAYPSPPD
  497-  530 (22.71/ 8.97)	.GQNqisLAKHRQQQiDRDLQfeigkVKLRYCPED
  547-  569 (40.47/21.39)	PGGK...FCRATNRK.KR........KRGFFYTPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.65|      22|     585|      33|      55|      11
---------------------------------------------------------------------------
   33-   55 (37.48/23.61)	YT.YSCSGDQlRSFITSTPSSEVE
  610-  632 (35.17/17.87)	YTsESCESES.ESDIESNDESEVE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.55|      16|      16|     265|     280|      12
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  265-  280 (25.88/15.07)	LFGLDLS..NLEEESSIP
  282-  299 (23.66/13.14)	LVHVQIThdNLTKDFPYP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.83|      25|     585|     648|     672|      14
---------------------------------------------------------------------------
  648-  672 (44.02/27.52)	LGFLNAGRLSMIFNIYVLCERRQLR
 1234- 1258 (47.81/30.46)	LSFMEVTTTHMCLPIHVLMVERCCR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16762 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNCDNKDSQAISPTTNDQTPGNISIVNEDSPSVGQNQISLAKHRQQQ
2) LGTTSPGVDTMTPNTPGMGNGTSSASSPGHNLGTGRSSKKRPLETKAYPSPPDAIQSNEIQMPPPQNDAELTDEIM
464
366
510
441










Molecular Recognition Features






MoRF SequenceStartStop




1) EPAWV
571
575