<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16740

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMCELFVCRRRYDLRKALEVQKGGLHHVSWFQFLPNESDLNALPDKSVKVDQKDAATFLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGRHSSVETAQAAVSRLRVVASGLWVAPGDSEEVAAALSQALRNCIERALNGLSYLRFGDVFSKYQPSQSEESFRKGHPTIEFIFAATEEAIFIHALVSAKHIHSLSGGDMEKGFKHSSSSSSSLRLPVIVSPHGMRGRLTGYCPTDLVKQVYFRTSNGCVGLPHVSQGSGCQLNGQNCYVEVTMGCPRSGSDKASHINSNSLRNLHKHNVSESPSVGGGDPKGSPDNMSAYEKTFIYPAEAVLVPVLQTSFSRSSLRSFGNMDSLEGSWIETNGIHAQRGYNSSSNSNNSSISSISGSSSDSDYQMNARTGDLEADADSLTCRQSGLSSNDQLENEGPKLGSKRPRTGMIESFGQMGTGTNASTDFGSVENTSAITGVANDQIGPHWDWDDDDDRGMGMDIQALLSEFGDFGDFFENENLPFGEPPGTAESQSFMFSAPDCGDVGSSPVVAMDVSDQMLMPNFSSFESFNPLPTMAVEECMGKSQEVTNNTLTSGQANQSQASSTGEFDHLMKAEALMTFAPEYGAVETPTSELSSSIFRSPYLPKSYRVESSNSSSNNYVYGATPPGSPCFDGSDEKNGTPVSKACSGKHDSSALLHSKKYYSHVESSKEQNDRKSVTHKDSNAKSDGLVLSPFSNLSSTNAIKSLPRKMTEGTLGVEHIFLSKKTVLATEVECLMFQASMCRIRHVLLYSSNPSPISLSRFTGSTVLNQLPGDLSSMTESTSGRYELKKKESIPVRIAGDFDGGLLDGHLNAPVGVWRSVGVAKVSKPTNSSSIEVSPSMPHGSFTEEGMISYGQRQPLQELLDGLPLLVQQATSFVDVALDADCGDGPYGWLALQEHWRQEFSCGPSMVHAGCGGTLASCHSLDIAGVELVDPLSADIHASSVISLLQSEIRTALKSAFGSLDGPLSVTDWCKGRGQSVDAAALGDGSTESISECRDSSSTITVGEALSPSQSSGGGSSSLKVAMDGTKLDETGQRRLNQDIGSSESDHQLCARLKPTLFVLPSPAILVGYQDDWLKTSATSLQFWEKAPLEPYALPKPITYNVICPDIDPLTSAAADFFQQLGAVYETCKLGTHSPQNLGNQMEIDSGKSPSSGFVLLDCPQSMKIESNNASLVGSISDYFLSLSNGWDLTSYLKSLSKALKTMKLGPCSSTQQKEGNSGPCTVIYVVCPFPEPLAILQTVIESSASLGSVAISSDRERALLHSQVGKALSCPAAVDETSISNVLAISGFSIPKLVLQILTVDEIFRVTSPAINELVLLKETAFTVYNKARRISRGSSGDVVHSSSLSSRSHSVMNQMASIPGMWKDCVGSRMTGPSLSREGEIDASLRPGTWDNSWQATRSGGLNCDPNRNGDFLIQDEIRFMFEPLFVLAEPGSLDHGVSSTFNGNSTSDDSTGGFMMSGSTAGSADTGSSSQLDRSEQDGFGSGHHKSVPSLHCCYGWTEDWRWLVCIWTDARGELLDSHIFPFGGISSRQDTKGLQCLFVQILQQGCQILQTCCSPDSGVAKPRDFVITRIGSFYELEYLEWQKAIYSVGGSEMKQWPLQLRRSVPDGMPSSTNGASLQQQQEISLIQERALPSSPSPLYSPHSKASGFMKGGLGQPVGRKQLIGGHTMVDNSRGLLQWVQSISFVAISIDHSLHLVHQADSPSSGGTQGGNGVGPSGYLEGFTPVKSLGATPASYILIPSPSMRFLPPAPLQLPTCLTAESPPLAHLLHSKGSAIPLSTGFVVSKSVPSMRKDHKNKLKDEWPSVLSVNLIDYYGGNNISQDKVTRVIIKQGGRTASSEPKDFEVETHLILESIASELHALSWMTASPAYLNRRTALPFHCDMVLRLRRLLHFADRELSQQADNPQS
Length1959
PositionKinase
OrganismCitrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Sapindales> Rutaceae> Aurantioideae> Citrus.
Aromaticity0.07
Grand average of hydropathy-0.297
Instability index51.60
Isoelectric point5.52
Molecular weight211099.07
Publications
PubMed=29259619

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16740
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     589.86|     195|     239|     596|     833|       1
---------------------------------------------------------------------------
  596-  827 (295.68/228.93)	TSGQAnqsqasstGEFD......HLmKAEALMTFAPEYGAVETPTSelSSSIFRSPYLPKSYRVESSNSSsnnyvYGATPPGSPCFDgsdeknGTP..VSKACS............GKHDSSALL.HSKKYYSHVESSkeqndrksvthkdSNAKSDGLVLSPFS.NLSSTNAIKSLPRKMTEGTlgVEHIFLSK.KTVLATEVECL...MFQASMCRIRH.....VLLYSSNPSPISLSRFTGSTVL..NQLPGDLSSMTESTS
  839- 1066 (294.18/164.33)	PVRIA........GDFDgglldgHL.NAPVGVWRSVGVAKVSKPTN..SSSIEVSPSMPHGSFTEEGMIS.....YGQRQPLQELLD......GLPllVQQATSfvdvaldadcgdGPYGWLALQeHWRQEFSCGPSM.............VHAGCGGTLASCHSlDIAGVELVDPLSADIHASS..VISLLQSEiRTALKSAFGSLdgpLSVTDWCKGRGqsvdaAALGDGSTESISECRDSSSTITvgEALSPSQSSGGGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     366.81|     100|     244|      23|     128|       2
---------------------------------------------------------------------------
   23-  124 (166.89/88.19)	GLHHVSWFQFLPNESDLNALPDKSVKVDQ......KDAATFLVLSSHLQLQKEGFLSTWTnSFVGPWDPSQGLHNPDEKIKLWLFlPGRHSSVETAQAAVSR..LRVVAS
  264-  364 (147.46/70.73)	GLPHVSQ....GSGCQLNG.QNCYVEVTMgcprsgSDKASHINSNSLRNLHKHNVSESPS...VGGGDPKGSPDNMSAYEKTFIY.PAEAVLVPVLQTSFSRssLRSFGN
  407-  452 (52.46/20.64)	.......YQMNARTGDLEADAD.SLTCRQ......SG......LSSNDQLENEG.......PKLGSKRPRTGM.....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.91|      49|     244|    1105|    1198|       3
---------------------------------------------------------------------------
 1105- 1158 (79.36/39.63)	LFVLPSPAILVGYqddwLKTSATSLQFWEKAPL......EPYALPKPITYnVICPDIDPL
 1228- 1282 (83.55/75.33)	FLSLSNGWDLTSY....LKSLSKALKTMKLGPCsstqqkEGNSGPCTVIY.VVCPFPEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.11|      51|     629|     511|     573|       4
---------------------------------------------------------------------------
  511-  573 (80.50/70.98)	FGDFGDFFENENLpfgeppGTAESQSFMFSAP.DCGDVGSSPVVAMDVSDQMlmpnfsSFESFN
 1166- 1217 (87.61/49.58)	FQQLGAVYETCKL......GTHSPQNLGNQMEiDSGKSPSSGFVLLDCPQSM......KIESNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.41|      66|    1170|     173|     244|       5
---------------------------------------------------------------------------
  173-  244 (106.95/73.33)	EESFRKGHPTIEFIFAATEEAIFIHAlvSAKHIHSLSGGDMekgfKHSSSSSSSLR..LPVIVSPHGM.....RGRLTG
 1350- 1422 (104.46/58.27)	DEIFRVTSPAINELVLLKETAFTVYN..KARRISRGSSGDV....VHSSSLSSRSHsvMNQMASIPGMwkdcvGSRMTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16740 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSDKASHINSNSLRNLHKHNVSESPSVGGGDPKGSPDNMSA
2) GSWIETNGIHAQRGYNSSSNSNNSSISSISGSSSDSDYQMNARTGDLEADADSLTCRQSGLSSNDQLENEGPKLGSKRPRTGMIESFGQMGTGTNASTDFGSVENTSAITGVANDQIGPHWDWDDDDDRG
3) NSTSDDSTGGFMMSGSTAGSADTGSSSQLDRSEQDG
4) SSSNNYVYGATPPGSPCFDGSDEKNGTPVSKACSG
5) VEECMGKSQEVTNNTLTSGQANQSQASSTGEF
293
370
1495
658
580
333
499
1530
692
611










Molecular Recognition Features






MoRF SequenceStartStop




1) IQALLSEFGDFGDFFENENLP
504
524