<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16726

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGELGQQTVPFSTLVSRAAEDSFASLKELVEKSKTGEEYDTDKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIHYSQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVFLTGSYQRLPKCIEDMGMQSTLTKDQQKAALKKLDTLVRAKLLEVSLPKEISEVKVSSGTALLRVDGEFKALVTLGYRGHLSMWRILHLELLVGERSGPVKLEESRRHVLGDDLERRMSAADNPFITLYSILHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSMGHGASGSSIQPNQDGEVDSAGLRTPGLKLIYWLDFDKNPGSSDSGSCPFIKIEPGPDLQIKCLHSSFVIDPLTGKEAEFALDQSCIDVEKLLLRAISCNRYTRLLEIQKELGKNIQICRAPSDVVLQSFMDELDADNRKKDNKSEFRDYEGQEVLRVRAYGSSFFTLGINIRYCYLLLPIAQILCYNFLHFTVYPKLIVVIYFERCHHLAKRNGRFLLQSSHKVLAPSVLSDCEEALNQGSTSAAEVFISLRSKSILHLFAAIGRFLGLEVYDHGFASMKVPKNLVNGSTVLLMGFPDCGSSYFLLMELDKDFKPMFKLVETQPDQSEKGQSSSDLNRVIRIKQIDISQMQILEDELNLSILNQGNLLSVMPNADGANHTSEQGLISEFNLDGSMHLAGCPLSSFSSVVDEVFEFEKGPAASSYTLQNVSSSFTTSSASHFGSLQMNLHGVKAGTPSPRWEGGVQMSHLNVAKGSIGNTQYNGSLYSSSNVKGPVQSSSFSSLSSGLARSTAVKKLPASKSDQDLASLRSPHSIEIGTVEEDLVSVGRSSRLLSPPRTASVRAPPPSAKPNGPRSSVTGSLAGSIKVAGSSSLASPPVSHAADTDIVSKHDKHPQKRTVSDMLSLIPSLQDIEAATGLSNKRRKISESAHFQQPLSGGLISAEIVSKAERYSYGNLVAEANKGNAPSSIYISALLHVVRHCSLCIKHARLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYTWRHICLRLGRPGSMHWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDSHIRFDPEGVVLSYQSVEDDSIKKLVADIQRLANARMFALGMRKLLGVRADEKPEEGTANFDVKAPVGGKGASEASDKLSEQMKRAFRIEAVGLMSLWFSFGSVVLARFVVEWESGKEGCTMHVSPDQLWPHTKCSFITDMHANNMPTLCCIEQFLEDFINGAEVASLLDCIRLTAGPLHALGAATRPARAGTGPGVPGVATAVSTIPKQTGYSSSQGLLPNGSTTNVSQVTSAPTGLNVSQVTSASTGNPVGAASTVPLGNPNLHGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDSNITGGQQTVGMANTNPSSGSQLASANGSRVNIPSSAAMSRAVNQVAALNRVGNPMPGSSNLSVVSSGLPIRRSPGASVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGHYPKLGGLRIVWKDIGYFNTLKKDFAIINSWRNEIGGKLSTEVGYVRGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQQNSSTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGEIAPSQKPRIELCLENHSGFNVDDGSVNSSASKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRTDEWEKCKQRVARVVEVNPVSAGDLTQGRLRIVADSVQRTLHMCLQGLKDGGTVTASSVGV
Length1927
PositionTail
OrganismCitrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Sapindales> Rutaceae> Aurantioideae> Citrus.
Aromaticity0.07
Grand average of hydropathy-0.145
Instability index45.00
Isoelectric point8.33
Molecular weight209788.88
Publications
PubMed=29259619

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16726
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.00|      47|      49|    1384|    1431|       1
---------------------------------------------------------------------------
 1384- 1431 (87.55/44.41)	LRgPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGG...PSVGGS.LPCP
 1433- 1483 (70.45/31.57)	FR.PFIMEHVAQELNGLDSNITGGQQTVGMANTNPSSGsqlASANGSrVNIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     230.23|      59|     164|    1000|    1059|       2
---------------------------------------------------------------------------
 1000- 1059 (104.64/65.09)	RLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYT..WRHIC.LRLG.RP..G.SMHWDVKiNDQ
 1093- 1153 (60.81/32.26)	RFDPEGVVLSYQSVEDDSIKKLVADIQ.RLANARMFAlgMRKLLgVRADeKPeeG.TANFDVK....
 1169- 1217 (64.79/35.12)	..SEQMK..RAFRIEAVGLMS....LWF..SFGSVVL..ARFVVeWESG.KE..GcTMHVS...PDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.93|      16|      18|     726|     743|       3
---------------------------------------------------------------------------
  726-  741 (29.47/10.37)	TSSASHFGSLQM.NLHG
  746-  762 (23.46/ 8.37)	TPSPRWEGGVQMsHLNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.40|      16|      72|     708|     724|       4
---------------------------------------------------------------------------
  788-  810 (20.10/ 9.18)	SSSFSSLSSGLarstavkKLPAS
 1508- 1526 (22.30/11.19)	SSNLSVVSSGL....pirRSPGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.03|      36|    1488|     318|     361|       9
---------------------------------------------------------------------------
  318-  361 (57.78/48.29)	LKLIYWldfDKNPGSSDSGscpfiKIEPGPDLQIK.CL..HSSFVID
 1746- 1784 (58.25/30.22)	LKLIAW...KKGLAQTQGG.....EIAPSQKPRIElCLenHSGFNVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.26|      15|      15|     678|     692|      10
---------------------------------------------------------------------------
  678-  692 (28.64/20.72)	SEFN..LDGSMHLAGCP
  694-  710 (19.61/11.22)	SSFSsvVDEVFEFEKGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.96|      34|    1488|     168|     207|      13
---------------------------------------------------------------------------
  130-  163 (56.44/29.73)	LPKCIEDMGMQSTLTKDQQKAALKKLDTLV.RAKL
  168-  202 (50.52/43.11)	LPKEISEVKVSSGTALLRVDGEFKALVTLGyRGHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.97|      43|      43|     835|     877|      14
---------------------------------------------------------------------------
  835-  870 (51.40/22.66)	...................VSVGRSSRLLSPPRTASVRAPPPSAKPNGP.RSSVTG
  871-  912 (58.86/26.93)	SLAGSIK..............VAGSSSLASPPVSHAADTDIVSKHDKHPqKRTVSD
  915-  966 (48.71/21.11)	SLIPSLQdieaatglsnkrRKISESAHFQQPLSGGLISAEIVS...KAE.RYSYGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.33|      17|      18|    1224|    1241|      17
---------------------------------------------------------------------------
 1225- 1241 (33.47/27.29)	SFITD.MHANNMPTLC.CI
 1243- 1261 (19.86/ 6.68)	QFLEDfINGAEVASLLdCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.79|      19|     308|    1532|    1553|      20
---------------------------------------------------------------------------
 1534- 1553 (34.51/25.35)	GElNTAIIGLGDDGGYGG..GW
 1844- 1864 (36.28/15.99)	GE.NPNVSFLGMEGSHGGraCW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16726 with Med14 domain of Kingdom Viridiplantae
Unable to open file!