<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16724

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGELGQQTVPFSTLVSRAAEDSFASLKELVEKSKTGEEYDTDKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIHYSQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVFLTGSYQRLPKCIEDMGMQSTLTKDQQKAALKKLDTLVRAKLLEVSLPKEISEVKVSSGTALLRVDGEFKALVTLGYRGHLSMWRILHLELLVGERSGPVKLEESRRHVLGDDLERRMSAADNPFITLYSILHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSMGHGASGSSIQPNQDGEVDSAGLRTPGLKLIYWLDFDKNPGSSDSGSCPFIKIEPGPDLQIKCLHSSFVIDPLTGKEAEFALDQSCIDVEKLLLRAISCNRYTRLLEIQKELGKNIQICRAPSDVVLQSFMDELDADNRKKDNKSEFRDYEGQEVLRVRAYGSSFFTLGINIRNGRFLLQSSHKVLAPSVLSDCEEALNQGSTSAAEVFISLRSKSILHLFAAIGRFLGLEVYDHGFASMKVPKNLVNGSTVLLMGFPDCGSSYFLLMELDKDFKPMFKLVETQPDQSEKGQSSSDLNRVIRIKQIDISQMQILEDELNLSILNQGNLLSVMPNADGANHTSEQGLISEFNLDGSMHLAGCPLSSFSSVVDEVFEFEKGPAASSYTLQNVSSSFTTSSASHFGSLQMNLHGVKAGTPSPRWEGGVQMSHLNVAKGSIGNTQYNGSLYSSSNVKGPVQSSSFSSLSSGLARSTAVKKLPASKSDQDLASLRSPHSIEIGTVEEDLVSVGRSSRLLSPPRTASVRAPPPSAKPNGPRSSVTGSLAGSIKVAGSSSLASPPVSHAADTDIVSKHDKHPQKRTVSDMLSLIPSLQDIEAATGLSNKRRKISESAHFQQPLSGGLISAEIVSKAERYSYGNLVAEANKGNAPSSIYISALLHVVRHCSLCIKHARLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYTWRHICLRLGRPGSMHWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDSHIRFDPEGVVLSYQSVEDDSIKKLVADIQRLANARMFALGMRKLLGVRADEKPEEGTANFDVKAPVGGKGASEASDKLSEQMKRAFRIEAVGLMSLWFSFGSVVLARFVVEWESGKEGCTMHVSPDQLWPHTKCSFITDMHANNMPTLCCIEQFLEDFINGAEVASLLDCIRLTAGPLHALGAATRPARAGTGPGVPGVATAVSTIPKQTGYSSSQGLLPNGSTTNVSQVTSAPTGLNVSQVTSASTGNPVGAASTVPLGNPNLHGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDSNITGGQQTVGMANTNPSSGSQLASANGSRVNIPSSAAMSRAVNQVAALNRVGNPMPGSSNLSVVSSGLPIRRSPGASVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGHYPKLGGLRIVWKDIGYFNTLKKDFAIINSWRNEIGGKLSTEVGYVRGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQQNSSTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGEIAPSQKPRIELCLENHSGFNVDDGSVNSSASKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRTDEWEKCKQRVARVVEVNPVSAGDLTQGRLRIVADSVQRTLHMCLQGLKDGGTVTASSVGV
Length1887
PositionTail
OrganismCitrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Sapindales> Rutaceae> Aurantioideae> Citrus.
Aromaticity0.07
Grand average of hydropathy-0.163
Instability index45.43
Isoelectric point8.16
Molecular weight204890.97
Publications
PubMed=29259619

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16724
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.09|      11|      14|    1310|    1320|       1
---------------------------------------------------------------------------
 1310- 1320 (20.42/10.03)	GNPNLHGAAML
 1326- 1336 (19.66/ 9.36)	GGPGIVPSSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     264.27|      69|     162|     960|    1031|       2
---------------------------------------------------------------------------
  960- 1031 (122.77/97.85)	RLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYT..WRHIC.LRLG.RP..G.SMHWDVKINDQHfrdLWELQKGS
 1053- 1113 (57.17/35.76)	RFDPEGVVLSYQSVEDDSIKKLVADIQ.RLANARMFAlgMRKLLgVRADeKPeeG.TANFDVK................
 1128- 1185 (84.32/58.26)	.LSEQMK..RAFRIEAVGLMS....LWF..SFGSVVL..ARFVVeWESG.KE..GcTMH....VSPDQ...LWPHTKCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.16|      41|     162|    1263|    1305|       3
---------------------------------------------------------------------------
 1263- 1305 (65.76/44.87)	SSSQGLLPNGSTTNVSqvTSAPTGLNVSQVTS.ASTGNPVGAAS
 1428- 1469 (67.40/40.22)	SGSQLASANGSRVNIP..SSAAMSRAVNQVAAlNRVGNPMPGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.10|      97|     162|     329|     488|       4
---------------------------------------------------------------------------
  329-  429 (157.07/87.71)	NPGSSdSGSCPFIKIEPGPDLQIKCLHSSFV.IDPLTGKEAEFALDQSCIDVEKLLLRAI.SC.NRYTRLLEIQKELGKNIQICRAPSDvvlQSFMDELDAD.NR
  489-  589 (145.02/134.93)	NQGST.SAAEVFISLRSKSILHLFAAIGRFLgLEVYDHGFASMKVPKNLVNGSTVLLMGFpDCgSSYFLLMELDKDFKPMFKLVETQPD...QSEKGQSSSDlNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.34|      26|    1448|     286|     311|       6
---------------------------------------------------------------------------
  286-  311 (47.22/25.28)	ISDGSMGHGASGSSIQPNQ.DGEVDSA
 1743- 1769 (42.12/21.77)	VDDGSVNSSASKSNIHYDRpHNSVDFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.57|      27|    1448|     127|     156|       7
---------------------------------------------------------------------------
  127-  156 (35.06/33.85)	YQRLPKCIEDMgMQSTLtKDQQkAALKKLD
 1536- 1562 (43.51/26.29)	FAQLPDLLKEI.LGSIL.KDNE.GALLNLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.17|      35|     583|     796|     830|       8
---------------------------------------------------------------------------
  723-  745 (28.19/10.46)	..................AKGSIGNTQYNG.......SLYSSSNVKGP
  759-  806 (43.34/19.99)	ARSTAVKKLPASksdqdlASLRSPHSIEIGtveedlvSVGRSSRLLSP
  807-  847 (54.63/27.09)	PRTASVRAPPPS......AKPNGPRSSVTG.slagsiKVAGSSSLASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.62|      37|    1307|     166|     205|      11
---------------------------------------------------------------------------
  166-  205 (59.59/38.57)	VS..LPkeiSEVKVSSGTAL.LRVDGEFK.ALVTLGYRGHL.SMW
  435-  459 (29.52/11.45)	.........SEFRDYEGQEV.LRVRAYGS.SFFTLG.........
 1474- 1513 (45.51/22.73)	VSsgLP.....IRRSPGASVpAHVRGELNtAIIGLGDDGGYgGGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.69|      14|      15|     626|     640|      12
---------------------------------------------------------------------------
  626-  640 (21.80/17.74)	DGANHTSEQGLiSEF
  643-  656 (26.89/17.11)	DGSMHLAGCPL.SSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.02|      13|      17|    1222|    1235|      14
---------------------------------------------------------------------------
 1222- 1235 (19.22/ 9.77)	RLTAGPlHALGAAT
 1239- 1251 (24.80/ 9.56)	RAGTGP.GVPGVAT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16724 with Med14 domain of Kingdom Viridiplantae
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