<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16724

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGELGQQTVPFSTLVSRAAEDSFASLKELVEKSKTGEEYDTDKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIHYSQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVFLTGSYQRLPKCIEDMGMQSTLTKDQQKAALKKLDTLVRAKLLEVSLPKEISEVKVSSGTALLRVDGEFKALVTLGYRGHLSMWRILHLELLVGERSGPVKLEESRRHVLGDDLERRMSAADNPFITLYSILHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSMGHGASGSSIQPNQDGEVDSAGLRTPGLKLIYWLDFDKNPGSSDSGSCPFIKIEPGPDLQIKCLHSSFVIDPLTGKEAEFALDQSCIDVEKLLLRAISCNRYTRLLEIQKELGKNIQICRAPSDVVLQSFMDELDADNRKKDNKSEFRDYEGQEVLRVRAYGSSFFTLGINIRNGRFLLQSSHKVLAPSVLSDCEEALNQGSTSAAEVFISLRSKSILHLFAAIGRFLGLEVYDHGFASMKVPKNLVNGSTVLLMGFPDCGSSYFLLMELDKDFKPMFKLVETQPDQSEKGQSSSDLNRVIRIKQIDISQMQILEDELNLSILNQGNLLSVMPNADGANHTSEQGLISEFNLDGSMHLAGCPLSSFSSVVDEVFEFEKGPAASSYTLQNVSSSFTTSSASHFGSLQMNLHGVKAGTPSPRWEGGVQMSHLNVAKGSIGNTQYNGSLYSSSNVKGPVQSSSFSSLSSGLARSTAVKKLPASKSDQDLASLRSPHSIEIGTVEEDLVSVGRSSRLLSPPRTASVRAPPPSAKPNGPRSSVTGSLAGSIKVAGSSSLASPPVSHAADTDIVSKHDKHPQKRTVSDMLSLIPSLQDIEAATGLSNKRRKISESAHFQQPLSGGLISAEIVSKAERYSYGNLVAEANKGNAPSSIYISALLHVVRHCSLCIKHARLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYTWRHICLRLGRPGSMHWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDSHIRFDPEGVVLSYQSVEDDSIKKLVADIQRLANARMFALGMRKLLGVRADEKPEEGTANFDVKAPVGGKGASEASDKLSEQMKRAFRIEAVGLMSLWFSFGSVVLARFVVEWESGKEGCTMHVSPDQLWPHTKCSFITDMHANNMPTLCCIEQFLEDFINGAEVASLLDCIRLTAGPLHALGAATRPARAGTGPGVPGVATAVSTIPKQTGYSSSQGLLPNGSTTNVSQVTSAPTGLNVSQVTSASTGNPVGAASTVPLGNPNLHGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDSNITGGQQTVGMANTNPSSGSQLASANGSRVNIPSSAAMSRAVNQVAALNRVGNPMPGSSNLSVVSSGLPIRRSPGASVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGHYPKLGGLRIVWKDIGYFNTLKKDFAIINSWRNEIGGKLSTEVGYVRGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQQNSSTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGEIAPSQKPRIELCLENHSGFNVDDGSVNSSASKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRTDEWEKCKQRVARVVEVNPVSAGDLTQGRLRIVADSVQRTLHMCLQGLKDGGTVTASSVGV
Length1887
PositionTail
OrganismCitrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Sapindales> Rutaceae> Aurantioideae> Citrus.
Aromaticity0.07
Grand average of hydropathy-0.163
Instability index45.43
Isoelectric point8.16
Molecular weight204890.97
Publications
PubMed=29259619

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16724
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.09|      11|      14|    1310|    1320|       1
---------------------------------------------------------------------------
 1310- 1320 (20.42/10.03)	GNPNLHGAAML
 1326- 1336 (19.66/ 9.36)	GGPGIVPSSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     264.27|      69|     162|     960|    1031|       2
---------------------------------------------------------------------------
  960- 1031 (122.77/97.85)	RLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYT..WRHIC.LRLG.RP..G.SMHWDVKINDQHfrdLWELQKGS
 1053- 1113 (57.17/35.76)	RFDPEGVVLSYQSVEDDSIKKLVADIQ.RLANARMFAlgMRKLLgVRADeKPeeG.TANFDVK................
 1128- 1185 (84.32/58.26)	.LSEQMK..RAFRIEAVGLMS....LWF..SFGSVVL..ARFVVeWESG.KE..GcTMH....VSPDQ...LWPHTKCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.16|      41|     162|    1263|    1305|       3
---------------------------------------------------------------------------
 1263- 1305 (65.76/44.87)	SSSQGLLPNGSTTNVSqvTSAPTGLNVSQVTS.ASTGNPVGAAS
 1428- 1469 (67.40/40.22)	SGSQLASANGSRVNIP..SSAAMSRAVNQVAAlNRVGNPMPGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.10|      97|     162|     329|     488|       4
---------------------------------------------------------------------------
  329-  429 (157.07/87.71)	NPGSSdSGSCPFIKIEPGPDLQIKCLHSSFV.IDPLTGKEAEFALDQSCIDVEKLLLRAI.SC.NRYTRLLEIQKELGKNIQICRAPSDvvlQSFMDELDAD.NR
  489-  589 (145.02/134.93)	NQGST.SAAEVFISLRSKSILHLFAAIGRFLgLEVYDHGFASMKVPKNLVNGSTVLLMGFpDCgSSYFLLMELDKDFKPMFKLVETQPD...QSEKGQSSSDlNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.34|      26|    1448|     286|     311|       6
---------------------------------------------------------------------------
  286-  311 (47.22/25.28)	ISDGSMGHGASGSSIQPNQ.DGEVDSA
 1743- 1769 (42.12/21.77)	VDDGSVNSSASKSNIHYDRpHNSVDFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.57|      27|    1448|     127|     156|       7
---------------------------------------------------------------------------
  127-  156 (35.06/33.85)	YQRLPKCIEDMgMQSTLtKDQQkAALKKLD
 1536- 1562 (43.51/26.29)	FAQLPDLLKEI.LGSIL.KDNE.GALLNLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.17|      35|     583|     796|     830|       8
---------------------------------------------------------------------------
  723-  745 (28.19/10.46)	..................AKGSIGNTQYNG.......SLYSSSNVKGP
  759-  806 (43.34/19.99)	ARSTAVKKLPASksdqdlASLRSPHSIEIGtveedlvSVGRSSRLLSP
  807-  847 (54.63/27.09)	PRTASVRAPPPS......AKPNGPRSSVTG.slagsiKVAGSSSLASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.62|      37|    1307|     166|     205|      11
---------------------------------------------------------------------------
  166-  205 (59.59/38.57)	VS..LPkeiSEVKVSSGTAL.LRVDGEFK.ALVTLGYRGHL.SMW
  435-  459 (29.52/11.45)	.........SEFRDYEGQEV.LRVRAYGS.SFFTLG.........
 1474- 1513 (45.51/22.73)	VSsgLP.....IRRSPGASVpAHVRGELNtAIIGLGDDGGYgGGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.69|      14|      15|     626|     640|      12
---------------------------------------------------------------------------
  626-  640 (21.80/17.74)	DGANHTSEQGLiSEF
  643-  656 (26.89/17.11)	DGSMHLAGCPL.SSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.02|      13|      17|    1222|    1235|      14
---------------------------------------------------------------------------
 1222- 1235 (19.22/ 9.77)	RLTAGPlHALGAAT
 1239- 1251 (24.80/ 9.56)	RAGTGP.GVPGVAT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16724 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SVGRSSRLLSPPRTASVRAPPPSAKPNGPRSSVTGSLA
796
833










Molecular Recognition Features






MoRF SequenceStartStop




NANANA