<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16603

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASITFRIYEPPPDQSHGFQSSALEIQSSLRDQGKLVSYDADRVGIWIFQIVSKDGTSKAVNSAPGSSLEASGYTLGMVEEGNLEPVALQKSRIPGNTTQNAPNNTASTASPAEANSRNPLISPTQVAGGALPEGVSQSSAQVTDMRTTQPVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLLADANERERGSLQADPVVGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGSDRSLAQTPNTQALSVRSVPDTNDSQWKHSCLKALEYCGLNPSQFKASPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPMEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRKAERMYAVTREVNGANPLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGITPSIDGAISSPNNPPPTLAVVDADMTMPTATPMADAENDAWGGQHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTAPAPQVMPPPVLSHPEPHKAIQPQPEVKPKPKTNDSVFAKPELKHARSSLNDELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESELESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDVTDEQLAIELPKLSKTESPEMLLHRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNSLQLLHDAIPSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVESFLSRLKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSHHKAAIIAEIWATTLTMISIWKVHWRVIITKSGAMDQKEVEWWQAASTLDDKHSFTMILMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGIKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1515
PositionKinase
OrganismFusarium oxysporum (Fusarium vascular wilt)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.380
Instability index47.76
Isoelectric point5.19
Molecular weight165311.95
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     803.62|     247|     615|     294|     586|       1
---------------------------------------------------------------------------
  309-  563 (411.44/207.42)	NDSQWKhSCLKALEYCGLNPSQFKASPW..VNLLISKP.TSQDADGESKRSRATvPWPGSLCFRKKPMEMSTTHRVGDTMLSGHEECHDPlgDARGWFAGASERE.ERISKRKAERMyAVTREVNGANPLAQnlNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGiTPS...IDGAISSPNNP....PPTLAVVDADMTMPTAT.......................PMADA..ENDAW..GGQH.EQKRERSDSNAMGDSDDVMNDLG.EDVF..GDHDVTEDDFNFFDGPDGND
  638-  745 (54.61/ 9.71)	...............................................................................................................................................RPDTAKRG...........................SSPFDP....ATVFKRVRASLSSPTKDdfavqpprrkssvfekvefdpkiPLINK..KYEH...GGAF.DFSKDQSN....GDSRPSAHNLS.RDEYleGQGKLKQTSKSLL....GNS
  766- 1021 (337.56/161.74)	NGHDWI.SEESELESDGDDISSLSGGPVspVKSSIKRTvVDDDALSQATTSRET.ELLDDVTDEQLAIELPKLSKTESPEMLLHRFFLDP..EPLNVDVGLSNHDfVEIAQIITEQA.ATGRLEIGIEHKAE..SSVSLATMRSHELSIARNSLQLLHDAIPSNLG.TPTavrLKGLLEIQDLPlvgqPSRL....QPRPIPGRD.......................PNAEQlrANNLYqiPVPHlEVRRSETKLSVLPSSMSFWEGLGlSPSW..GTKDISA..LCIFPGWKG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.65|      54|    1174|      25|      78|       2
---------------------------------------------------------------------------
   25-   78 (93.29/59.60)	EPPPDQSHGFQSSALEIQSSLRDQGKL.VSYDADRVGIWIFQIVSKD.GTSKAVNS
 1200- 1255 (89.36/56.76)	EQPPPRMIDFKLTTSPSQSLMHENSCLhVGYAESLDGRWITAAWTDNrGQRQATTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.95|      20|     931|     127|     149|       3
---------------------------------------------------------------------------
  128-  147 (34.67/27.10)	AEANSRNPLISPTQVAGGAL
 1395- 1414 (35.29/13.89)	AEAEADSFLIDATDQTWGAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.98|      16|     613|     564|     583|       5
---------------------------------------------------------------------------
  566-  582 (26.84/20.34)	MDMPDLQPApTAPAPQV
  588-  603 (30.14/ 6.81)	LSHPEPHKA.IQPQPEV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16603 with Med13 domain of Kingdom Fungi
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