<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16596

Description Related to SRB8-DNA-directed RNA polymerase II holoenzyme and Srb10 CDK subcomplex subunit
SequenceMGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPAGSASSTLMPMPTRRPVTSQPRFAPRITATAPAPAKKDARPKPYTVEIPSVAPRYFSANRPETAVRNPVDPFSKGLNSGYADFFPWNGAHHEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDQDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKSLIMKTVVEWATSFHRPGLAKVYAATRLIRQWSQFRVNPTTPILETLDNIAANDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHALSEKKRAERGNLLRRAGNYSVAEEEQDITNAIRVVKHVVGLPLLSNDPLSGRKPMSLKKLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHSLSLTMFTAVRDIMEMAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSANELFNSLIERLRMMNEEQRLVPRPLLAALSSLAQRMAGHEVVASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVERTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVFATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQNLAPESSRGPATYLQELLQLVIMPLPQATGLVAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVNGTEFPLDNLECQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGETQISFDHILQIANELTLPFCQLKLNLDLSLPQPSVIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETLPPATVGSLVQQVFDIAILLVDALPEELRANCARATLLTPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1519
PositionKinase
OrganismFusarium oxysporum (Fusarium vascular wilt)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.201
Instability index52.23
Isoelectric point8.80
Molecular weight167345.72
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16596
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.26|      59|     101|     801|     863|       1
---------------------------------------------------------------------------
  801-  863 (93.38/69.00)	SDILGACAKTADSDVLASVADTVHSNLQifcaLD..SANELFNSLIERL.RMMNEEQ..RLVPRPLLA
  902-  965 (86.88/53.87)	SDIVATPSHQAENNVAEEVERTLSSGTR....LDppTMNKLFRMIIPALeRGWEKEDdtRRVFATLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.67|      33|      93|       8|      62|       3
---------------------------------------------------------------------------
   11-   40 (51.47/23.18)	..........................SVSSSSLPVQRPP....PQRSLSHQQQFMA.AASP
   54-  113 (35.33/37.95)	AGDatpnryhttprrggsrlrlelshNASSSSLPTSESPqsltPSR.IPNSDPFQAmVGSP
  114-  136 (33.86/ 7.18)	AGS........................ASSTLMPM...P....TRRPVTSQPRF.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.61|      33|      93|    1287|    1323|       4
---------------------------------------------------------------------------
 1287- 1323 (56.55/46.84)	PPKmaqlSLG.MVEKLTDL.WEIVAAGPQE.RPNCHAAVL
 1383- 1418 (45.06/27.68)	PPA....TVGsLVQQVFDIaILLVDALPEElRANCARATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      12|     101|    1336|    1347|       5
---------------------------------------------------------------------------
 1336- 1347 (23.23/10.85)	LHSLSSEPPSAP
 1435- 1446 (25.43/12.63)	LYYLFSSPPPSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16596 with Med12 domain of Kingdom Fungi
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