Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKYIDGRFERVEKALANLIDSVTKYHPSIQQGEELNAADQELSRGLKEVQTHQNNYLRIQQLRESSNALDTQIRDTLSNLATTRKDIVTTQTTTFPSGPSYPIAYEELLNYARRISKTTMPPAGTIKAVPPTPDVPEVQTPGGQTPAAQTPGPESQAASVMTPSAPPSSQVQSPAVMNGTPVVSQEPATQQSSMSANTVLPSEWTQFLNPLTDQIFLPWPNDLQLGAGSLAANQLLQEQGIDPKGYDPAEEEERKRREEEERKQKEEEDRIAQEEREKKQREERERQRIERERQREKEQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 346 |
Position | Middle |
Organism | Fusarium oxysporum (Fusarium vascular wilt) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.074 |
Instability index | 64.65 |
Isoelectric point | 4.72 |
Molecular weight | 38813.15 |
Publications | PubMed=30202022 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP16594 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.18| 14| 15| 258| 271| 1 --------------------------------------------------------------------------- 258- 271 (24.42/11.35) REEEERKQKEEEDR 274- 287 (24.77/11.60) QEEREKKQREERER --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 71.17| 23| 28| 76| 103| 2 --------------------------------------------------------------------------- 76- 103 (32.99/31.14) DTLSNLAttRKdivTTQTTTFPSG.....PSYP 107- 134 (38.18/21.27) EELLNYA..RR...ISKTTMPPAGtikavPPTP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.29| 13| 15| 152| 164| 3 --------------------------------------------------------------------------- 152- 164 (24.61/11.59) PGPESQAASVM..TP 168- 182 (18.68/ 7.20) PSSQVQSPAVMngTP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.79| 14| 28| 30| 43| 4 --------------------------------------------------------------------------- 30- 43 (24.06/15.55) IQQ.GEELNAADQEL 60- 74 (19.73/11.46) IQQlRESSNALDTQI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IAYEELLN 2) QEAWRRASLVGGPA 3) QQKAQFQFTNLDDLDDD | 104 300 326 | 111 313 342 |
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