Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MATLNLDDDELKALEQTLSKVAQLSSSVQSFRQDLLKSNPLPPPKSIQASAKILQKNLKSLLESTNENADLFNRMAIRPSTNYPGRTQENVLLQLLRKKLEPDVEEFVSQGLETARLATPEGLESLEQIWRELRSWLSDRVIHFISTENSDPYTAEERANGVKNVRTGLRRPIDDDEEEEDEEEGDEEEDDEEPEKPEIPEVKVRGAEPETLLWFAARGDFEVPRNVEYERKVDVYKGLQGINIPPSDQQQQQQGFVPS |
Length | 259 |
Position | Head |
Organism | Fusarium oxysporum (Fusarium vascular wilt) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.871 |
Instability index | 57.42 |
Isoelectric point | 4.49 |
Molecular weight | 29527.31 |
Publications | PubMed=30202022 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP16587 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 187.43| 67| 72| 88| 158| 1 --------------------------------------------------------------------------- 14- 65 (55.33/26.29) .....................LEQT...LSKvaQLSSSVQSFRQDLLKSNPLPPPKSIQASAKILqKNLKSLLEST 71- 140 (107.38/61.45) LFNRMAIRPSTNYPGRtqeNVLLQL...LRK..KLEPDVEEFVSQGLETARLATPEGLESLEQIW.RELRSWLSDR 141- 179 (24.72/11.29) VIHFISTENSDPYTAEeraNGVKNVrtgLRR..PIDDDEEE................................... --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LLWFAAR 2) RNVEYERKVDVYKGLQGINIPP | 212 225 | 218 246 |
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