<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16581

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAQVANGHSSAHLNGQTSTNGTHENGVHELSPEELERHLPAVYDGQVPLGELVSRTVQAIYAELSELAETLPNMSDSARKRSLADWVVQTKKQVVKLYAVVKWARDADVVQKAMNMTGFLMEQNRQFEDAIQSLKTCRDALDSARLRNHDLLTSLDVLTTGSYRRLPTAIKKLVIPPTPLTDEEVAKTLADVEDVIRFRLKMNEIIPPEMSNYRIADGRVYFTAPKLFEVSLCVKGAQKDEGWFFVNVEFLFAIGGDRSGTQEFPRRPTGQVKRHITDEADARLAFYLSVPEDQIPPGVELPPRPQLPPGVVDAPLVRIFNFLQMMSLSYQLEILRWQAERLRSLGWAEYLQVERSNNRQTLTISYWIRKPPPTQQGRPQPAQRAKIPLLGGKIIVSIARAQTTPNNKSNRSPKARMLAELQEKAKLDTGRPSDEVEPFKFDVKWEPEKGALGVIIPEEDSRMSPSTLAIESDNLDVEALLRKVIARHTEAVLKVIQTQLQLAPATRNIFSHPGEIVITQEEGMHVLRTRLCADEFVVIAIDPRTGRLNLRDTGDLASAGKTRRYALFADKVNENPTLLSEILIRLKFSTIIDMAEQKANYLGLRMFRTRNFSQEEIRKLGPSTRGLLYIQLAKFPSHYLVIVITEEDFRYALISAEVLEDIPFHKMVMKDIGWLDVHRVHGHEIVVTPRIGGDDDVVAGQKRKRDMADDLGRVDVAQPYPPRFNLDIQVLRELYAYCCARVAYYKIEQQFKSRNIPYSIVSSTNAAQLPELASQSSLARSIPALCVQSSVILSGAPAAEAAMPNIRVIPLNWWSDRQAQVVTCVKLKYVQQPVGKRAGSSSVIRPSKRIIYDSTEAIVSFLSEDVDKCVDEFLEEWARVSKMVVIAREVAQMSRKKRWSDVRLLSFDLQTVEFAYTADYTLSITCTDQLSPTGGTYDLQFSRIAKEQTSTGEEGRSYNPHEDLEPYLRSLLQHGPLAPSLNKLVAILRDTLPIVAELEDIRVAAAKLGENVDILPKSAGWFRVLYGDFRHALDFRLMTGARVIILDASHSLFLAEGRGPSGAASAQVLGRKDRDIDDGLLLQPIPDFQTMVGDAVKAAVAQGTTGQIAAIDIGVVCASSAVRTVGRTLYERVLQRLKHPQGGN
Length1144
PositionTail
OrganismWolfiporia cocos (strain MD-104) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Wolfiporia.
Aromaticity0.07
Grand average of hydropathy-0.242
Instability index46.77
Isoelectric point7.61
Molecular weight127985.19
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16581
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     322.49|     109|     193|     684|     808|       1
---------------------------------------------------------------------------
  684-  808 (157.52/141.61)	EIVVTPRiggdddVVAGQKRKR......DMADDLGRVDVAqpYPPRFNLDIQVLREL......YAYCCARVAYYKIEQQFKSRNI.PYSIVsstnAAQLPELASQSSLARSIPALcvqSSVILSGAPAAeAAMPNIRV
  882- 1003 (164.97/106.53)	KMVVIAR......EVAQMSRKKrwsdvrLLSFDLQTVEFA..YTADYTLSITCTDQLsptggtYDLQFSRIAKEQTSTGEEGRSYnPHEDL....EPYLRSLLQHGPLAPSLNKL...VAILRDTLPIV.AELEDIRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.38|      34|     193|     388|     462|       2
---------------------------------------------------------------------------
   68-  103 (53.40/21.30)	AETLPNMSD..SARKRSLADwvVQTK.........KQVVKLYAVVKW
  401-  445 (48.98/74.23)	AQTTPNNKSnrSPKARMLAE..LQEKakldtgrpsDEVEPFKFDVKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.11|      67|     777|     224|     305|      10
---------------------------------------------------------------------------
  224-  305 (100.41/96.67)	APKLFE.VSLCVKGAqkdeGWFFVnvefLFaigGDRSGTQEFpRRPTG.QV.............KRHITDEADARLafyLSVPEDQIPPGVELPPRP
 1005- 1086 (104.70/62.50)	AAKLGEnVDILPKSA....GWFRV....LY...GDFRHALDF.RLMTGaRViildashslflaeGRGPSGAASAQV...LGRKDRDIDDGLLLQPIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16581 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQTTPNNKSNRSPKARMLAELQEKAKLDTGRPS
2) MAQVANGHSSAHLNGQTSTNGTHENGVHELSPEEL
401
1
433
35










Molecular Recognition Features






MoRF SequenceStartStop




1) LTISYWIRKP
362
371