<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16575

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAARPHAAAQDNTGSSVLAQFPPQVSQASPILGSVISLPASPLIAYSIFTGAPTTNISEHLNLIELARRRILLRNARHDLLDSLLPSVHITKDYSALYVFAFGSTDRTSEAHSALAALQLDGLLLSESSTFTPSSIYPCSSSCAAQSIPCPECLNPSRPPARSSAAAQFFPRSSLRLPFHFFLTAVRDRLIDDITEASKRSPEQRQATRLKGGFLLGPCSASSEWSAGWDDSARGRPLIYTHLEVQLSCPTSGASPPARLLVHPVLRPTFYLPLCDHLPTAAGTPITLLPHGVPAYYLSTYSGPTSALTAQFDETLTGLGAGDWKGLLAAAAGQADPSASGSGSGAAKAAGYVIAWLAVQNKQGEDKGMPVIWPVRLCLAYHPSSPSVHARTPLPYHPELPAQLQASPPPPPAVVPAGIPVAKAAAASPAEDETQPATPPQSQATLPEREQLQTPIAPRPRTLTSSPTAESLRAFRSMTLSAKPYTRDVRNVASEVSGYVDSVAKERERERERMKRERENANARGRTASMSGNLPTLNTPPSVPPTSTPDVAGAEEVIAPAAEVTPAPVPTPIAVSIPEAVPDVKPMDVDVDPADDEPSSSQDSSTNSLFSPPSGSASSSPAGEDPMQISEETQVATQPVSRNTLPPTTDAPPVIARSDPFDFFGELSTSWSQPNDFMSMDTGYDMGFNMNIGSLGDSRSGGGDNGMFVLDDGLEVFTDDDFNFFDAPTTRNPAAPMTPLQVDSLIKSEGLTPATGFGFSPQRIGDGIPLSGPGPPLSQPSPWTPFAPASGFNTQAVDFHPAIGIPPAPDLLPASPTRTLSSYSAPATPAVQLADPQESLGTGKANRLSLGPSIFDPIPFATSHRFADGKYTFGKFALPSPSDDEDRAESLFIPSSAPSSLNGWRLKYSVATDPRIGVMRKLIGIKRKSFTQGIRELRLLPPWLKEHEEWESSASSPWAEEARSEGDSEEEEPWIDDDDVTAVSRPTTPPPSYLPLGPTLLQTNFHHSRLLPLSSPLRPPGAAVQASSSNNVLVSVPTPVSPAAVLGAASEKSKSLEAAAQLLVKELVENTAWADAWRENMAVSQNSQGHPSEVWQTDVKRVEWLLSNIDPLQTPLALHVLYGQETSSSTTSESASSSKLMLLAPPALAVGKSGTVVQLLPSALRFWEKLGLGPRAGSKDVTAFVFYEATSEDRESQLSQWLDNVSKAYSARNYGAHVPGTAIDCARPGLIPARLDSFKKTLGNFIATLSPYPGSNLVFYIITPISVIDPASPSLRQIFSAIKRASKQHPDVEILYHLVPEALTASGYGDSRSSHGGLESFAASVYDRILRPVERFMTRPLSAAQLSSRACFQAPSYALARARMATGSVQVGPRIRYALEPQPSSLDVMDRLTFLHVGYQLSSCGRWILAACVDEWGDAYELGAWLAPEEQLEISIASQVWAFALNFAKRANIEWRIVLAKLGTMHASELTAWTELLDNEVSKPSQVPPMHVTLLAAAHTNPWFFISPNDASHARPPLNASPPATSRSSSRTHHGVVFANMSTAIYAVLPPLEISLVPSIDCGASGENDIGAANRPFIPDNDEEEPLLQQHSSLRTSGHSMLIHVPAGRDHTSIHMTHFHRLYATRSRSSSKRRPAIDKDAAGQGPAADEPDVDDDRTFVELTQNYHALAVLAQSRWNLTDYPELPLHLAALEVMRVALSGEPAGP
Length1706
PositionKinase
OrganismWolfiporia cocos (strain MD-104) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Wolfiporia.
Aromaticity0.07
Grand average of hydropathy-0.244
Instability index58.52
Isoelectric point5.43
Molecular weight182732.15
Publications
PubMed=22745431

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16575
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1301.78|     255|     255|     531|     785|       1
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  126-  316 (146.62/42.52)	...........................................................................................SESSTFTPSSIYPCSSscaaqsiPCPEclNP..........SRPPA..R.....SSA.AAQFFPRSSlrlPFH.......FFltavrdrliddiTE........ASKRSPEQ..RQATRLKG.G..............F.LLGPCSA....S....................................SEWSAGWDDsarGRPLIYTHLEVQLS.......C...................PTS..GASPPARLLVhpvlrptfylplcDHLPTAAG.TPIT...LLPH....GVPayylstYSGPTS..........ALTAQFDETL
  332-  526 (238.45/73.46)	AG......QADPS..ASGSGSGAAKAAGYVIAWLAvqnkqgEDKGM.PVIWPVRLCLayhPSS.PSVHartPLPYHPElPAQLQASPPPPPAVVPAGIPVAKAAAAS.......PA.E..D......ETQPATPPQS..QATLPEREQlQTPIAPR............................................PRTLTSSPTAESLrA..............FrSMTLSA...............................................................KPYTRD............................VRNVASEVSG.YV.............DSVAK..............ERERERER......MK...R..........ERENANARGR
  531-  785 (451.76/145.33)	SG.NLPTLNTPPS..VPPTSTPDVAGAEEVIAPAA......EVTPA.PVPTPIAVSI...PEAVPDVK...PMDVDVD.PADDEPSSSQDSSTNSLFSPPSGSASSS.......PAGE..DPMQISEETQVATQPVS..RNTLPPTTD.APPVIARSD...PFD.......FF............GE......LSTSWSQPNDFMSMDTGYDM.G..............F.NMNIGSL....G....................................DSRSGGGDN...GMFVLDDGLEVFTDDDFNFFDA...................PTTRNPAAPMTPLQV.............DSLIKSEGLTPATGFGFSPQRIGDGIP......LSGPGP..........PLSQPSPWTP
  790- 1004 (211.63/64.43)	SGfNTQAVDFHPAigIPP..APDL...................LPAsPTRTLSSYSA...P.ATPAVQ.......LAD.PQE............SLGTGKANRLSLG.......PSIF..DPIPFATSHRFADGKYTfgKFALP.....SP.....SD...DED.......RA............ES......LFIPSSAPSSLNGWRLKYSV.A..............T.DPRIGVMrkliGikrksftqgirelrllppwlkeheewessasspwaeEARS.EGDS........EEEEPWIDDDDVTAVSR...................PTT..PPPSY...........................................LP......L...GP..........TLLQTN....
 1011- 1273 (253.33/78.47)	....LP.LSSPLR...PPGAAVQASSSNNV..............LV.SVPTPVS......PAA.............VL.GAASEKSKSLEAAAQLLVKELVENTAWA.......DAWR..ENMAVSQNSQ..GHP.S..EVWQTDVKR.VEWLLSNID...PLQtplalhvLY............GQetssstTSESASSSKLMLLAPPALAV.GksgtvvqllpsalrF.WEKLG.L....G.....................................PRAGSKDV...TAFV..............FYEAtsedresqlsqwldnvskaYSARNYGAHVPGTAI.............DC..ARPGLIPARLDSFK.KTLGNFIA......TLSPYPgsnlvfyiitPISVIDPASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.88|      48|     218|    1279|    1334|       2
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 1279- 1334 (66.92/46.81)	FSAIKRASKQHPDVeilyHLVPEALTASgygDSRSSHG.GLESFAASVYdRILRPVE
 1505- 1553 (81.97/37.75)	FISPNDASHARPPL....NASPPATSRS...SSRTHHGvVFANMSTAIY.AVLPPLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      20|     481|     940|     959|       3
---------------------------------------------------------------------------
  940-  959 (41.06/18.49)	LPPWLKEHEEWE.SSASSPWA
 1422- 1442 (30.87/12.28)	LGAWLAPEEQLEiSIASQVWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.59|      40|    1332|       4|      48|       4
---------------------------------------------------------------------------
    4-   48 (60.94/41.21)	RPHAAAQdnTGSSVLAQFPP.QVSQASPILGSVislPASPLIAYSI
 1339- 1379 (65.66/32.61)	RPLSAAQ..LSSRACFQAPSyALARARMATGSV...QVGPRIRYAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16575 with Med13 domain of Kingdom Fungi
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