<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16573

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMPMEEPPWKKLKLSLERPYKDDDGEPVPVLLDITPDGQHIYEPKEDPTAKVGENLRRIFLERGIDFFDRRKHEGHKVAEPTAAQEDEGKEKHKDDAQGPKQPMTAEELFKMRMEILPQLHIALGEMCQARDLLVLLLATGAPLQATSSQSIAAQLTQPSSSQPSLSQPPPTGAQLPPSALSATVATKPPPISSVQAFNAQLVVGGKDRALRKAADMFKSAAESIEAGRVRSERYWLDALKIRRGNWGLVPAPLPFGSSTGRGADRTAKDFLVSFGLEESPALFRRRAIGRMPTIETDQSSLEFPLRQRARLQVSFYTTDAYGNRLRARNRMPVPDESTLAGSLRAAQAEVVEQEIFAALIREASSLPTASARVSERLIVIEAAQGTELRFELVRTPARTSELDDSSDAAICDLIFSSLHVLLLRAHALLRTERLMRTSSHRTQAQSAARQSPVVPPILQPVIDMLMYQDFCERVKSEVGRFVAGLQAAGVRTGLQFTAVGGSGEEFVRNLRTERPRPIEGQALIRVDNRHTLRFTFISPSTLIAHLPQATLQIMSIPQLTQLLTDDIGGCLLKRICDIGAERCGAVNGTWFVDVMTGQAVGRWEGCAL
Length608
PositionHead
OrganismWolfiporia cocos (strain MD-104) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Wolfiporia.
Aromaticity0.05
Grand average of hydropathy-0.285
Instability index58.36
Isoelectric point7.65
Molecular weight66963.86
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16573
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.50|      17|      17|     154|     170|       1
---------------------------------------------------------------------------
  154-  170 (31.95/18.72)	QLTQPSSSQPSLSQPPP
  174-  190 (30.55/17.57)	QLPPSALSATVATKPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.16|      35|      35|     468|     502|       2
---------------------------------------------------------------------------
  468-  502 (59.58/38.37)	QDFCERVKSEVGRFVAG..LQAAGVRTGLQFTAVGGS
  504-  540 (56.58/36.07)	EEFVRNLRTERPRPIEGqaLIRVDNRHTLRFTFISPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.12|      13|      35|     388|     400|       3
---------------------------------------------------------------------------
  388-  400 (23.83/15.97)	LR.FELVRTPA..RTS
  423-  438 (14.29/ 6.49)	LRaHALLRTERlmRTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.46|      17|      17|     306|     322|       4
---------------------------------------------------------------------------
  273-  291 (21.32/10.89)	SFGLEEspALF.....RRRAIGRM
  292-  313 (20.75/10.40)	PTIETD..QSSlefplRQRARLQV
  314-  333 (25.39/14.38)	SFYTTD..AYG..nrlRARNRMPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.66|      14|      15|     115|     129|       5
---------------------------------------------------------------------------
  115-  129 (21.16/19.39)	ILPQLhIALGEMCQA
  132-  145 (22.51/14.09)	LLVLL.LATGAPLQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.43|      17|      35|     217|     239|       6
---------------------------------------------------------------------------
  217-  239 (20.95/29.93)	FKSAaesieAGRvRSERYWLDAL
  255-  271 (30.48/20.33)	FGSS.....TGR.GADRTAKDFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.63|      16|      21|     340|     355|       7
---------------------------------------------------------------------------
  340-  355 (26.23/17.31)	AGSLRAAQAEVVEQEI
  363-  378 (26.39/17.46)	ASSLPTASARVSERLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.67|      18|      19|      68|      85|       8
---------------------------------------------------------------------------
   68-   85 (30.29/20.56)	DRRKHEGHKVAEPTAAQE
   90-  107 (31.38/21.57)	EKHKDDAQGPKQPMTAEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16573 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPMEEPPWKKLKLSLERPYKDDDGEPVPVLLDITPDGQHIYEPKEDPT
2) RKHEGHKVAEPTAAQEDEGKEKHKDDAQGPKQPMTAEELF
3) SSQSIAAQLTQPSSSQPSLSQPPPTGAQLPPSALSATVATK
1
70
147
48
109
187










Molecular Recognition Features






MoRF SequenceStartStop




1) LRRIFL
2) MPMEEPPWKKLKLSLERPYKDDDGEPVPVLLDI
55
1
60
33