Description | Mediator of RNA polymerase II transcription subunit 4 (Fragment) |
Sequence | LAEGRRELGEIVREGEERAQAIRDAKAAAIPYPELLAYAQSISAFTSAPPNMPDLALPGQPPPPLFFPPFPNEEKMRRGHLNTEEPLGLLGETHSVGKPPTVSVELPSHIAGPGANPYRPDLRPPPQQVFDLDLDLNPDL |
Length | 140 |
Position | Middle |
Organism | Wolfiporia cocos (strain MD-104) (Brown rot fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Wolfiporia. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.497 |
Instability index | 64.24 |
Isoelectric point | 4.79 |
Molecular weight | 15211.02 |
Publications | PubMed=22745431 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP16572 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 123.98| 35| 54| 35| 69| 1 --------------------------------------------------------------------------- 35- 69 (67.44/23.37) LLAYAQSISAFTSAPPNMPD.LALPGQPP..PPLFFPP 89- 126 (56.54/18.62) LLGETHSVGKPPTVSVELPShIAGPGANPyrPDLRPPP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IRDAKAAAIPYPELLAYAQSISAFTSAP 2) PLFFPPFPNEEKMRRGHLNTEEPLGLLGE 3) PYRPDLRP 4) QQVFDLDLDLNPDL | 22 64 117 127 | 49 92 124 140 |
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