<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16566

Description "Mediator complex, subunit Med12"
SequenceMIPHPSLTGLQTWTSQHRASGTADRSSMAVAPAPSSAQQLIDLSGSDGPAENEHPHKRPRLDTTVSGLGGDGRTPSSRSADARSATTGSNPTRPSAVSGRGRPAYSFQELVADTYGGNVFAGNVTPGSQTSKPPSPPPFPVRPWTHTPARLSQVENEGLSNNMRGRVVQTVPYHPETPEMAPSLTREKVADYAPWSRTGNHPEDRLSDLNVKAGNFDRVPGPNTNSDIQSHASKLSSQLKNHSSLQLLSSVFAAALEKRQINEKISSASTFKPPPRVTLTDNKREAWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLGKGVPIGRAVWLAKCVGANEIRAFKRKGTSGSLSQGLETKWVREWTLSVQQFTAGVISACGKPDWRNKMTYAVRLAARLFYEHLLDQDCYLDWYLSSMEGSSLDAFPIWLAMLSIYWGSLVRFRKRGRRLAETLLEKLREATSSEFKVNLQPLIERVSLLVRRLCRENSPCLILPRSWDRYQDVVASSLSDDSREKAILQSLVLRNARVQRPGTYCPSRQRSPQEQVIKLLDASRDTCDMCALSSSCLALVPDRQELVSVLLRWAASPFRQGLVRVYIAVRLFRKWKRSGMDIDACIFPFLTQTSIEQSTSMTNVYHIIVELIRSQTFSVGRYLQWLVARGAVEQYRQHYSPASSVPVDIALLSHIPVSRLPRHLRNLRDTLMARAGLSSSEGEVLHSIKADLKQRLPSLLGKDDFHMNINYDQSNLSWSVKADISQWIRAAVSEHYENGLAYHTKIYENSVEVSSLTREEFLAVRSILEQYGDLSMLADILIDASNSDDVRLLTCAVDTLNRHFECFTIIGALGDLFRSFYEAFLRVKTNGQPLYDLAYSMVEVGHRLPNEVNSLVLLRQELSRADRNLALAACSPVSDHMAETLNDASPSFNEDMDHFLSSGNSMDEMTMILVFQKLIQQLAFYNEKSPSTPGSKLLQSGSLQPANSALPDSLVDFLELLVPNYGAEPLYDFLAYRFRIAQEEFLHGHSHEAFALLRDAVPHMTLGTEDLVSSIPCVVPLLSEIVVRHPEDATLESIRALMKAYPIFLPVVRKSLDLLLSDHQSEPEFLMETAMTIKKTNHLSLPLCQMKLQILFDEKNDDSIRNSIVDLMYKSAVADVRAGNTYWLDLVSTMGQEAAEQLRQRAEKDFFSVAQSESTPEKDSENEKLSLQDNARVYLAIVDGLAYSIPEEGVPTVAPVLVEKMNTLLQKLFTMHMNVRTWTEQRTRSSQEAMTRSLSGSEENFVFWLTAMLQMIRIHRAAFDLPASSGNQRLGAYVDLSRLLIIICCLALSRTPLGLTVQPRLDLSASSYFLASAKEVRAGNTIQTYALDIASSLVDSLPDEARQHCANFIKERFPPALNVQNDPRLQYLFGPVAENFGNLGGTLPSSMSVSSPAATLTPSNNPVNTAAAAGGNTIEDPLAINNRLRVQSRGRVVGSYPLRPWEMLEEAAPVVGANDTAIDLNLFGARKVRDY
Length1505
PositionKinase
OrganismPenicillium sp. 'occitanis'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.256
Instability index49.33
Isoelectric point7.20
Molecular weight167410.49
Publications
PubMed=28951729

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16566
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.39|      26|     135|     842|     869|       1
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  842-  869 (45.25/31.42)	ALGDLFRSFYEafLRVKTNG.QPLYD.LAY
  979- 1006 (41.14/22.34)	ALPDSLVDFLE..LLVPNYGaEPLYDfLAY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     310.51|     108|     136|     559|     694|       2
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  354-  497 (148.90/89.10)	QGLETKWVReWTLSvqQFTAGVISacgkpdwrnkmtyaVRLAARLFYE...HLLDQD.CYLDWYL.SSMEGSSldafpiwlAMLSIY..WGSLVRFR..KRGRRL....AETLLEKLREATSSEFKVnlqPLieRVSLLvrrlcrENSPCLILPRSW
  574-  694 (161.61/165.13)	QELVSVLLR.WAAS..PFRQGLVR..............VYIAVRLFRKwkrSGMDIDaCIFPFLTqTSIEQST........SMTNVYhiIVELIRSQtfSVGRYLqwlvARGAVEQYRQHYSPASSV...PV..DIALL......SHIPVSRLPRHL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.05|      50|     199|    1149|    1209|       3
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 1149- 1209 (73.54/64.21)	DVRAGN...TYWLDLVSTMGQEAAEQLRQRAeKDFFsvaqSESTPekdsenEKLSLQDNARV.YL
 1349- 1402 (79.51/45.37)	EVRAGNtiqTYALDIASSLVDSLPDEARQHC.ANFI....KERFP......PALNVQNDPRLqYL
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.37|      73|     136|      87|     173|       4
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   88-  119 (23.93/13.63)	........................................................GSNPTRPSAVSGRGRPAYSFQELVADTyggNV
  122-  167 (60.50/46.86)	GNVTPGSQTSKPP....SPPPFPVRpwTHTPARLSQVENE.GLSNNM....RGRV.................................
 1414- 1496 (105.93/56.55)	GGTLPSSMSVSSPaatlTPSNNPVN..TAAAAGGNTIEDPlAINNRLrvqsRGRVvGSYPLRPWEMLEEAAPVVGANDTAIDL...NL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.62|      49|     221|     786|     838|       5
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  786-  838 (78.63/62.89)	LTREEFLAVRSileqYGDLSMLADIL..IDASNSDDVRLLTCAVDTLN....RHFECFT
 1010- 1064 (74.99/50.48)	IAQEEFLHGHS....HEAFALLRDAVphMTLGTEDLVSSIPCVVPLLSeivvRHPEDAT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.23|      32|     363|     519|     565|       6
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  519-  550 (52.83/22.37)	QSLVLRNARVQRPGTYCPSRQRSP.QEQVIKLL
  883-  915 (43.52/15.84)	NSLVLLRQELSRADRNLALAACSPvSDHMAETL
  941-  968 (43.87/34.74)	MILVFQKL.IQQLAFY...NEKSP.STPGSKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.96|      49|    1044|     168|     216|       9
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  168-  196 (40.89/25.39)	...........................VQTVPYHPETPEMAPSLTREKVADYAPWS
  197-  216 (19.63/ 7.46)	RTGNHPEDRLSDLNVKAGNF....................................
 1256- 1311 (69.44/49.47)	RTRSSQEAMTRSLSGSEENFvfwltamLQMIRIHRAAFDLPASSGNQRLGAYVDLS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16566 with Med12 domain of Kingdom Fungi
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