<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16562
Description |
Cyclin C/H/T/L |
Sequence | MKRFYTKVDFRQTNPYLVMVTAFYLACKMEECPQHIRVVSSEARQLWPEFITNDPAKIGECEFYLISEMHSQLIVHHPYRTVLELTKPLELTTEDVSQATTLISDHYQTDLPLLYPPHVIAVMAILLAVMFGGGGGAAAHRNPYGHGAIVANPPSISTSLREAGLGVTLSALGGSNAPAAAGATRPDPRISRIVTWLAESEVDIKAVIECTQEMISLYEVMDGVNIQQCKEIISRMIKTRNADK |
Length | 244 |
Position | Kinase |
Organism | Penicillium sp. 'occitanis' |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.000 |
Instability index | 51.50 |
Isoelectric point | 5.90 |
Molecular weight | 26971.84 |
Publications | PubMed=28951729
|
Function
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The SRB8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The srb8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
ECO:0000256 ARBA:ARBA00002306
ECO:0000256 ARBA:ARBA00003882
|
GO - Cellular Component | integral component of membrane GO:0016021 IEA:UniProtKB-KW
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP16562
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 102.36| 31| 35| 129| 162| 1
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129- 162 (52.21/43.22) VMFGGGGGAAAhrnPYGHGAIVANP..PSISTSLRE
167- 199 (50.14/32.64) VTLSALGGSNA...PAAAGATRPDPriSRIVTWLAE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.75| 21| 39| 9| 29| 2
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9- 29 (38.84/29.66) DFRQTNPYLVMVTAFYLACKM
49- 69 (37.91/28.79) EFITNDPAKIGECEFYLISEM
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|