<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16561

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLVMDDVSASASRDWGDSYNRHGSNGDPTVMREAQQVDNFGKSDNPQQVNGFKGDDGKGQGSNTAIVLKNGQSGVMPNGVQGQWAPPLMHITQGFFPYSQLVHRAVQQCYNDLCDVITELADSTQQQQSSSANGKPDPAAIQKRIRILEFAQTKRTEFIKLLVLSQWSRQAVDVSKLIDLQNFIRTRHFAYQTAVQRVADMKRDLVRAQVANPDLQTALEVLTTGRVSNMPEFGYKPPKPLSSKRLLATLRKINRIISTRLVTSDTVPPPLNEYRVHDGRVTFSVQGEFELDLSIAEEDVASQFYFIDIRFLFAPSSPIPKGRFFNELDSQINGILKTKGLTGCFDFIHNLVLVNKINILFKQATSLSRGQWTGALRVELLHRILVVHYWPDKSGPKSWLEIGAHSGRQQRQKVSYLGLRWVRDGKECESSQIHFNTETLSMESILRSVIAIHSSHTLRAVYERLCTQDLFANHRLSIYMQMSKIEPGNCRLNVQLTETRFLNASLEPVSGAMCIHTIPSLLCRLDKGSASDDDFVNRISRLRCIAAMEEIESDAKIFGWESVDHRKFKVDIRRVFPNNILRASFFRNRLWGNSWIIAATTSLSGDDWWILRLKARPSSYPDGPGHGRVVAGGFSVQSTRVSSSVQLLSPRESGYHFPDLDYSLTGALVMYSNALWLSELGYQDVLPPVDQLQLGSRLEVPCLYLKFDSAKLPKQLRIGPLDGTQSKSYVRETLTISYHGIDSRTKNAIVVAHGRFHTALRKMGLKRLKLDDCILLRRGGTAFAMRFLVAPGQSIMIDLFERIQRLNIVLSLFHTLQQNKITVKSVSLSSLSFVYAPREGFEANIVIRLDGPSHAPDLDPTVIRLQNEPLFRLRLDMSFNNLSPHNRIKQSLGMILNQSGPGNGVQCVLQLLKLTLSVLHALDRLVTEPQHNSALRVQVSIRGAHTYQIHYFGLRFRFLLNASHRRDKIIWTLKDISSAEGQRDVEHAVEAKLQEKIYRGKGDGWQGLGNGAVAEVDQVGNLLSELDSCFADLTPPPAPPAAPRETAEKKPGKATKDKGPKTNGTSKVTNRQPQEVPKETDVIMID
Length1088
PositionTail
OrganismPenicillium sp. 'occitanis'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.307
Instability index41.28
Isoelectric point9.37
Molecular weight121995.07
Publications
PubMed=28951729

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16561
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.29|      27|      32|     487|     517|       1
---------------------------------------------------------------------------
  487-  517 (44.63/44.87)	IEPGNCRLN.VQLTETRFLNaslePVSGAMCI
  520-  547 (43.66/32.68)	IPSLLCRLDkGSASDDDFVN....RISRLRCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.01|      14|      15|     692|     705|       2
---------------------------------------------------------------------------
  692-  705 (24.37/14.15)	DQLQLGSRLEVPCL
  710-  723 (23.64/13.50)	DSAKLPKQLRIGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.00|      45|     283|      42|     136|       3
---------------------------------------------------------------------------
   42-   89 (79.70/112.62)	FGKSDNPQQVNGFKGDDGKGQGSN....TAI.VLKNGQSGVMPngvQGQWAPP
  191-  240 (69.30/23.54)	FAYQTAVQRVADMKRDLVRAQVANpdlqTALeVLTTGRVSNMP...EFGYKPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.24|      33|     283|     587|     629|       4
---------------------------------------------------------------------------
  587-  629 (48.86/58.23)	FFRNRLwGNSWiiaatTSLSGDDwwilRLKARPSSY..PDGPGHG
  872-  906 (54.38/33.57)	LFRLRL.DMSF.....NNLSPHN....RIKQSLGMIlnQSGPGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.32|      38|     487|     439|     477|       9
---------------------------------------------------------------------------
  439-  477 (61.83/39.98)	TETlSMESILRSVIAIHSSHTLRAVYERLCTQDLF.ANHR
  929-  967 (64.49/37.74)	TEP.QHNSALRVQVSIRGAHTYQIHYFGLRFRFLLnASHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.11|      18|     331|     319|     336|      10
---------------------------------------------------------------------------
  319-  336 (34.02/19.21)	SPIPKGRFFNELDSQING
  651-  668 (35.10/20.04)	SPRESGYHFPDLDYSLTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16561 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASASRDWGDSYNRHGSNGDPTVMREAQQVDNFGKSDNPQQVNGFKGDDGKGQGSNTAIVLKNGQ
2) CFADLTPPPAPPAAPRETAEKKPGKATKDKGPKTNGTSKVTNRQPQEVPKETDVIMID
11
1031
74
1088










Molecular Recognition Features






MoRF SequenceStartStop




1) ETAEKKPGKATKDKGPK
2) GTSKVTNRQPQEV
1047
1066
1063
1078