<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16560

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGDATTNFSAINGFSVIHWRIYTEEATTGNPEIAPNSGYNILRHLSRLKDLEIQLRNSDCLVSCYPRRLGLWIFSPTPGFESLSPLTRDPAAPGLKESTKLTIGTSSLKVSAFGSITAIDLIRSLSTDGFTSAAGASGQTTRPAGASVNAPRSSDAYANSMAIYASFITAMAGAIGLQLVKRHNAIPLGARTFYTAVERNFYDNPAIGDDVVDSIPALTTLRIELTQAGKIVVALHTVHQDGISRLKEPGTAETNAANIQNNIDVWLAPNGTVARLIAVNTEQSAVFAPKQAKSEDAVRQITEAKQRVWKTTVLEWLNNVGLPVDHPEDEHWVEVEVSEPFYARLAAEHLRQMDDSQSSSPLKRILWPSRYCFRRTKIVPSNTTEKFSEHAYDGEEPLHFAQTWLKTATSRHEKPKDDSSNIQERSQNEGISGTIKFEVPEKIESLARVIHYPDLQNASSVYPTPPDGALAPGINQINSDTLGPDGHDFGLSHTPAGETPMKQQENVRKASNDNASFEHMNAMEVGTGLYDTNDDDELFSGMNDKDFGSKGLTDADFSFFDDDDDEMNDFLNDKPETEPAQEEVLHPVSDEATEVPVAQAEIPEAQVAQEENSFEQDEMQQSTDIEASAPSQIDVKQSSATPYTVTLQEAPPVPPEHVISAPLSPTDIKQMLFSNKDARLQDEKRRASTSSNPGSERKQSRYNAISFKRGLSLDQKYANAGRFFFTSNKDSNENINTTPGIPTIGFPSWRKSGHRPSVDEINTLHQMSSEQPMQRTDSASSDESSLDSSDDDSEDETSPFRLATLKRKRPLSEAEKSTTSSMEKLSITSEVESHVSKEDTSIFLGNFFSVFTDWSLVGYFSAKQSQVSPVTSRKEDQMQIAQLMVDQLTQSSLSHKIEGWESDPNLEYETFGLHTFLDDITNLGESEKLDLKSYVTIHDSVQATAETPSTRPNPQRREVKGSITKIAPSHLRIHRGRDYLEVLSTSMPFWETFGLEPASGRKDVSAYCICPEFSKEEADAFMTRLELLYSGCNLGKHIRGDMFEAFENGIGLWNIAKGDGSYARTMQTLRGLCEDLASALSKAPQTGENFVIYIINPFSHGAAFVDICSTFLHLFHKYVGDVDKNKDKSQLNELVLQIVPLNFVFSPTSMVVPPQSQYLNLALEVYSRCPPKDASSGIIGYAPPVVLADAVPKAINFRVTSEHFSPFQEGRCLHVAISRSIDQRWISVAWTNNSGSCQIAMSYCVRARGSNVNRIISEVRQEIWEATKDLMERTQTRWKVLLVRTEPIDQEEIDAWTGFAERYNQAKALPVELTLFSVNIAPGLRLEPPTTQFSVNAINPLASTPVATPYGGVSSPDQLGAATPASGGQGPATMNYSTAMTPTDTPPVLAEADSDAVLIDACEESWAVILSHRLSNSAYLTDYKPALVSGYLLRRKGVNDSQGVTAMSLNLIYTSRPPALHEAVLREALTNYRDLATLARAKGTLHVQHNTLPWHIATAVKGQELLSFVL
Length1513
PositionKinase
OrganismPenicillium sp. 'occitanis'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.426
Instability index50.23
Isoelectric point5.06
Molecular weight166777.12
Publications
PubMed=28951729

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16560
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.23|      15|      15|    1317|    1331|       1
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 1317- 1331 (27.02/18.21)	TLFSVNIAPGLRLEP
 1334- 1348 (27.21/18.40)	TQFSVNAINPLASTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     439.73|     124|     246|     732|     856|       2
---------------------------------------------------------------------------
  467-  627 (120.88/72.03)	.........TPpdGAL.APGINQINSDTLGPDGHDFGL.SHTPAGETPM.KQQENvrkASNDNASFehmnamevgtglydtndddelfsgmndkdfgskgltdaDFSffDDD.DDEMNDF..........LNDKPETEPAQEEVLHPVSDEatevpvaqaeipEAQVAQEENS.FEQDEMQQSTD
  632-  730 (118.77/70.36)	APSQIDVKQSS..ATPyTVTL...QEAPPVPPEHVISApLSPTDIKQMLfSNKDA...RLQDEKRR......................................AST..SSNPGSERKQSRYNAISFKRGLSLDQKYANAG..RFFFTS....................................
  732-  856 (200.09/128.98)	KDSNENINTTP..GIP.TIGFPSWRKSGHRPSVDEINT.LHQMSSEQPM.QRTDS...ASSDESSL......................................DSS..DDDSEDETSPFRLATLKRKRPLSEAEKSTTSSMEKLSITSEV............ESHVSKEDTSiFLGNFFSVFTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.61|      14|      15|    1031|    1044|       3
---------------------------------------------------------------------------
 1031- 1044 (26.44/18.40)	LYSGCNLGKHIRGD
 1049- 1062 (26.16/18.12)	FENGIGLWNIAKGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.19|      12|      15|     908|     919|       4
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  908-  919 (22.50/15.87)	NL.EYETFGLHTF
  925-  937 (15.69/ 8.71)	NLgESEKLDLKSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.15|      68|     913|      20|      95|       5
---------------------------------------------------------------------------
   20-   95 (104.24/97.70)	IHWRIyteEATTGNPEIAPNSGYNILR.HLSRLKDLEIQL.RNSDCLvSCYPRRLGLWifsPTPGFESLSPlTRDPAA
  940- 1009 (108.91/75.20)	IHDSV...QATAETPSTRPNPQRREVKgSITKIAPSHLRIhRGRDYL.EVLSTSMPFW...ETFGLEPASG.RKDVSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.82|      51|     913|     271|     324|       6
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  271-  324 (77.35/54.08)	APNGTVARLI..AVNTE.QSAVFAPKQAKSEDAVrQITEAKQRVWKTtvLEWLNNVG
 1185- 1238 (82.47/47.99)	APPVVLADAVpkAINFRvTSEHFSPFQEGRCLHV.AISRSIDQRWIS..VAWTNNSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.24|      11|     378|       4|      16|       7
---------------------------------------------------------------------------
    4-   14 (20.92/18.52)	PGDATTNFSAI
  252-  262 (20.31/ 7.97)	PGTAETNAANI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16560 with Med13 domain of Kingdom Fungi
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