<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16558

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTDTRIVQDLITPLSSSSLSLNTNDIQGTFAITAEWILDVARWHASDINDEHQIGGLMSSPDALALFESLGILLVALSATAKGHEALASESTSDFKIPLGQALTAYLSTSATISLNLRNRLDSLQKGYQLYGEPPSKDLDVQMMDGMNMNALQFEASVLDGPVINSRAGLYIYINALLIGRPLIDDEMLLSYLSNRYGGHQEVLIQELITATFDVLSNAMYRNESTRNMFVFRSFLVNKLPPFIAGMAATSIEQIPMEMCISHALNRVDPNAFPSFSQMFEMQGNTVLSDVRQEFLFACALHRLIPEASIERLLGENPMQTLPVGGRYVKNDIVAQILSNQGAADRLISEIELMEGNAGAVVAAVTDVIHSLCEQKETVTLKSICDSLSRRPQVLDVMLLFRSPKSILQPLCTLLDSWKWDEDQGESQPVYDEFGSILLLVMAFKYRYDLSQYDLGVTASSSFVLKLFERGSTSMKLAGLNAKQNKSVGDWISALFMSEGISEETWSSCSPQEFYLLVATLFSQTLGACEMGMLELDTMKGGFEYLLQPFLLPSLVFALKWLGNYIWESSEADLLLLLKVLHALVKPSSISGEAEACHRTVLNIAARSLEEQLKDVRTRLPGGRSDNQSDIQPSPHQDIQQEIQALLDILDPYLSFQCNGNSRRSELDSWTTHADGICGVIRVTFQGLILWSASAEMSMSPHAYTHRLILTGIRLSTASNVLSVLLDELKAQAEEASGSLDLAIDIAATLICAPIPESFAQEQTIYHPIDTTKEAFPRCLLLTLRQALMIQHQNVPKLSEKDPTRAEVIVRLTRRVNALLTPPAHVGTLDVTNIIDNMNLEAAAAAAAAGHDVIDLGNGNGSANDQGGASGESIDQILNNVVAAAANNDHHGAGNEPHDLDTTGMDTSLDDILNAAHMGNPEFLDLDMDGMF
Length932
PositionTail
OrganismPenicillium sp. 'occitanis'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy0.015
Instability index41.83
Isoelectric point4.64
Molecular weight102021.97
Publications
PubMed=28951729

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16558
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.92|      28|      28|     878|     905|       1
---------------------------------------------------------------------------
  844-  882 (32.87/19.32)	AAAAAAGHDvidlGNGNGSAN.DQGGAsgesidqiLNNVV
  883-  913 (47.29/31.43)	AAAANNDHH....GAGNEPHDLDTTGM.....dtsLDDIL
  914-  931 (30.75/17.55)	NAA....HM....G.NPEFLDLDMDGM.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.66|      17|      28|     682|     698|       2
---------------------------------------------------------------------------
  682-  698 (29.88/23.00)	RVTFQGLILWSASAEMS
  707-  723 (26.78/19.71)	RLILTGIRLSTASNVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.10|      20|      28|     782|     804|       3
---------------------------------------------------------------------------
  782-  804 (31.19/28.75)	LTLR.QALMIQHQNVPKLsekDPT
  812-  832 (30.91/19.65)	LTRRvNALLTPPAHVGTL...DVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.52|      21|      28|     365|     387|       4
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  365-  387 (32.38/33.45)	VTDVIHSLCEQKEtvTLKSIC...DS
  394-  417 (32.14/24.86)	VLDVMLLFRSPKS..ILQPLCtllDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.45|      18|      22|     149|     166|       5
---------------------------------------------------------------------------
  149-  166 (30.07/21.78)	MNALQFEASVLDGPVINS
  174-  191 (29.38/21.09)	INALLIGRPLIDDEMLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.71|      33|      33|     240|     272|       9
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  238-  270 (58.92/46.35)	NKLPPF...IAGMAATSIEQIPMEMCISHALNRVDP
  271-  306 (53.79/41.57)	NAFPSFsqmFEMQGNTVLSDVRQEFLFACALHRLIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.07|      29|     400|      51|      79|      10
---------------------------------------------------------------------------
   51-   79 (47.83/28.37)	EHQIGGLMSSPDALALFE..SLGILLVALSA
  452-  482 (41.24/23.49)	QYDLGVTASSSFVLKLFErgSTSMKLAGLNA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16558 with Med5 domain of Kingdom Fungi
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